Results 161 to 170 of about 11,851 (177)

Blocking autophagosome closure manifests the roles of mammalian Atg8-family proteins in phagophore formation and expansion during nutrient starvation

Autophagy
Macroautophagy/autophagy, an evolutionarily conserved cellular degradation pathway, involves phagophores that sequester cytoplasmic constituents and mature into autophagosomes for subsequent lysosomal delivery.
Fang Tian, Van Bui, Yoshinori Takahashi
exaly   +2 more sources

GORASP2 promotes phagophore closure and autophagosome maturation into autolysosomes

Autophagy
As the central hub of the secretory pathway, the Golgi apparatus plays a crucial role in maintaining cellular homeostasis in response to stresses. Recent studies have revealed the involvement of the Golgi tether, GORASP2, in facilitating autophagosome ...
Xiaoyan Zhang
exaly   +2 more sources

A conserved ATG2‐GABARAP family interaction is critical for phagophore formation [PDF]

EMBO Reports, 2020
The intracellular trafficking pathway, macroautophagy, is a recycling and disposal service that can be upregulated during periods of stress to maintain cellular homeostasis.
Alan R. Prescott, Luuk van den Bekerom, David G McEwan   +2 more
exaly   +2 more sources

The proppin Bcas3 and its interactor KinkyA localize to the early phagophore and regulate autophagy [PDF]

Autophagy, 2021
To resolve the signaling mechanisms that mediate the starvation-induced processes of Dictyostelium sporulation and encystation, we performed insertional mutagenesis on cells harboring an mRFP-tagged spore gene.
Pauline Schaap, Yoko Yamada
exaly   +2 more sources

Classical swine fever virus hijacks ESCRT-III and VPS4A to promote phagophore closure for accelerating mitophagy

Autophagy
Classical swine fever virus (CSFV) infection induces complete mitophagy, which is essential for the clearance of damaged mitochondria. The endosomal sorting complex required for transport (ESCRT) machinery plays a vital role in mediating phagophore ...
Yan Cheng, Yu-hang Li, Xiao-Qing Bi, Jin-Xia Chen, Bing-Qian Zhao, Ji-Shan Bai, Yinbo Ye, Qi Dai, Lin-Ke Zou, Jing Chen, Xiu L. Feng, Bin Zhou   +11 more
semanticscholar   +1 more source

Endosome-ER contact sites in phagophore formation.

Trends in Cell Biology
Autophagy is a crucial 'self-eating' mechanism used by eukaryotic cells to degrade and recycle cytosolic materials. A recent study by Da Graça et al. reports that the dynamic mobilization of endosome-endoplasmic reticulum (ER) contact sites (EERCS) in ...
Meng-Nan Xu, Pingping Wang, Xian-Ping Dong   +2 more
semanticscholar   +1 more source

FREE1 regulates phagophore closure in plants

Autophagy
Adenosine monophosphate-activated protein kinase (AMPK), the central energy sensor in more complex eukaryotes, can activate macroautophagy/autophagy upon cellular energy deficiency. However, the regulatory role of nutrient sensing in mediating phagophore
Ying Zhu, Yong-Lun Zeng, Li-Wen Jiang
semanticscholar   +1 more source

In situ architecture of developmentally programmed mitophagy reveals ER-phagophore membrane continuity

Autophagy
Selective mitochondrial clearance by autophagy (mitophagy) is essential for development and cellular homeostasis. However, how phagophores acquire sufficient membrane to engulf large mitochondria remains poorly understood.
Yu-Fei Huang, Tian-Yue Zheng, Xiao-Feng Sun, Ruoxi Wang, Shu-Jun Cai   +4 more
semanticscholar   +1 more source

Control of phagophore membrane expansion: Atg8-Atg1 as the master switch

Autophagy
Autophagosome formation is catalyzed by multiple branches of Atg protein machineries, calling for the existence of a master regulator to coordinate their distinct activities. A prime candidate of such a regulator is Atg8.
Yi-He Feng, Jing Zhu, Yu Ding, Fan Yan, Zhi-Ping Xie   +4 more
semanticscholar   +1 more source

Atg21 organizes Atg8 lipidation at the contact of the vacuole with the phagophore

Autophagy, 2021
Joerg Enderlein, Ralf Ficner, Janina Metje-Sprink   +2 more
exaly