Results 1 to 10 of about 696,985 (149)
Morphology of Phagophore Precursors by Correlative Light-Electron Microscopy
Cells, 2022 Autophagosome biogenesis occurs in the transient subdomains of the endoplasmic reticulum that are called omegasomes, which, in fluorescence microscopy, appear as small puncta, which then grow in diameter and finally shrink and disappear once the ...
Sigurdur Runar Gudmundsson +5 more
doaj +1 more source
Key Regulators of Autophagosome Closure
Cells, 2021 Autophagy is an evolutionarily conserved pathway, in which cytoplasmic components are sequestered within double-membrane vesicles called autophagosomes and then transported into lysosomes or vacuoles for degradation.
Wenyan Jiang +6 more
doaj +1 more source
Frontiers in Pharmacology, 2021 Phosphodiesterase 11A (PDE11A), an enzyme that degrades cyclic nucleotides (cAMP and cGMP), is the only PDE whose mRNA expression in brain is restricted to the hippocampal formation.
Katy Pilarzyk +5 more
doaj +1 more source
Autophagy Reports, 2023 ATG9A is an important membrane protein in mammalian macroautophagy. The formation of autophagosomes and phagophores is blocked in atg9a KO cells. However, it remains possible that residual membrane formation activity exists in these cells.
Soichiro Kakuta +4 more
doaj +1 more source
A mechanism that ensures non-selective cytoplasm degradation by autophagy
Nature Communications, 2023 In autophagy, a membrane cisterna called the isolation membrane expands, bends, becomes spherical, and closes to sequester cytoplasmic constituents into the resulting double-membrane vesicle autophagosome for lysosomal/vacuolar degradation.
Tetsuya Kotani +6 more
doaj +1 more source
Casein Kinase 1 Family Member CK1δ/Hrr25 Is Required for Autophagosome Completion
Frontiers in Cell and Developmental Biology, 2020 Autophagy starts with the initiation and nucleation of isolation membranes, which further expand and seal to form autophagosomes. The regulation of isolation membrane closure remains poorly understood.
Yuting Li +8 more
doaj +1 more source
Isolation of Intact and Functional Melanosomes from the Retinal Pigment Epithelium. [PDF]
PLoS ONE, 2016 Melanosomes of retinal pigment epithelium (RPE) have many vision supporting functions. Melanosome research would benefit from a method to isolate pure and characterized melanosomes.
Laura Pelkonen +4 more
doaj +1 more source
Agglutination of Isolated Platelet Membranes [PDF]
Arteriosclerosis, Thrombosis, and Vascular Biology, 1996 AbstractPlatelet membrane glycoproteins play a central role in platelet aggregation and thus in primary hemostasis. To investigate mechanisms of platelet-platelet interaction in the absence of cellular activation events, we studied immunological and functional aspects of isolated platelet membranes.
M, Gawaz +4 more
openaire +2 more sources
The autophagic membrane tether ATG2A transfers lipids between membranes
eLife, 2019 An enigmatic step in de novo formation of the autophagosome membrane compartment is the expansion of the precursor membrane phagophore, which requires the acquisition of lipids to serve as building blocks.
Shintaro Maeda +2 more
doaj +1 more source
Dynamics of bilayer membranes 1. Isolated membrane [PDF]
Colloids and Surfaces A: Physicochemical and Engineering Aspects, 1996 By adopting the approximations suggested in the theory of thin shells, the hydrodynamic theory of liquid crystals established by Eriksen [Arch. Rational Mech. Anal. 4 (1960) 231; Trans. Soc. Rheol. 4 (1960) 29] and Leslie [Adv. Liq. Cryst. 4 (1979) 1] is modified so that it is applicable to study the lipid bilayer membranes.
openaire +2 more sources