Results 221 to 230 of about 357,951 (342)

A synthetic benzoxazine dimer derivative targets c‐Myc to inhibit colorectal cancer progression

Molecular Oncology, EarlyView.
Benzoxazine dimer derivatives bind to the bHLH‐LZ region of c‐Myc, disrupting c‐Myc/MAX complexes, which are evaluated from SAR analysis. This increases ubiquitination and reduces cellular c‐Myc. Impairing DNA repair mechanisms is shown through proteomic analysis.
Nicharat Sriratanasak, Bodee Nutho, Worawat Wattanathana, Narumon Phaonakrop, Bunnatut Panasawatwong, Katharina Erlenbach‐Wuensch, Sittiruk Roytrakul, Regine Schneider‐Stock, Pithi Chanvorachote   +8 more
wiley   +1 more source

Evaluation of image quality in mobile cone-beam CT with dose modulation using automatic exposure control: A phantom study. [PDF]

J Appl Clin Med Phys
Okazaki K, Cao W, Taleei R, Mourtada F, Li J, Mooney K, Anne PR, Chen Y.   +7 more
europepmc   +1 more source

ANTHROPOMETRIC “PHANTOM” ANALYSIS OF COLLEGIATE MALE AND FEMALE ATHLETES.

, 1980
Jason Conviser, W. E. Sinning
openalex   +1 more source

Adaptaquin is selectively toxic to glioma stem cells through disruption of iron and cholesterol metabolism

Molecular Oncology, EarlyView.
Adaptaquin selectively kills glioma stem cells while sparing differentiated brain cells. Transcriptomic and proteomic analyses show Adaptaquin disrupts iron and cholesterol homeostasis, with iron chelation amplifying cytotoxicity via cholesterol depletion, mitochondrial dysfunction, and elevated reactive oxygen species.
Adrien M. Vaquié, Davod R. Shah, Eliane E. S. Brechbühl, Michael McNicholas, Zhaoyang Xu, John H. Stockley, Laura Morcom, Diana Gold Diaz, Gemma C. Girdler, Rachel V. Seear, Gabriel Balmus, Rajiv R. Ratan, Harry Bulstrode, James A. Nathan, Manav Pathania, Kevin M. Brindle, David H. Rowitch   +16 more
wiley   +1 more source

Repeatability and reproducibility of rapid T₁ mapping of brain tissues at 64 mT: A multicentre study. [PDF]

Imaging Neurosci (Camb)
Lena B, Padormo F, Teixeira RPAG, Bennallick C, Gholam J, van den Broek R, Lafayette SL, Vavasour I, Cercignani M, Jones DK, Kolind S, Hajnal J, Bourke N, Dong Y, Hollander WJ, Karaulanov T, Deoni SCL, Williams SCR, Sundgren PC, Webb AG, Ljungberg E.   +20 more
europepmc   +1 more source

The Great Grey Owl - phantom of the northern forest, by Robert W. Nero [Review]

, 1981
Daniel F. Brunton
openalex   +2 more sources

Patient‐specific pharmacogenomics demonstrates xCT as predictive therapeutic target in colon cancer with possible implications in tumor connectivity

Molecular Oncology, EarlyView.
This study integrates transcriptomic profiling of matched tumor and healthy tissues from 32 colorectal cancer patients with functional validation in patient‐derived organoids, revealing dysregulated metabolic programs driven by overexpressed xCT (SLC7A11) and SLC3A2, identifying an oncogenic cystine/glutamate transporter signature linked to ...
Marco Strecker, Keren Zohar, Martin Böttcher, Thomas Wartmann, Henry Freudenstein, Maximilian Doelling, Mihailo Andric, Wenjie Shi, Or Kakhlon, Katrin Hippe, Beatrix Jahnke, Dimitrios Mougiakakos, Franziska Baenke, Daniel Stange, Roland S. Croner, Michal Linial, Ulf D. Kahlert   +16 more
wiley   +1 more source

Clinical comparison of four commercial MRI phantoms on a 0.35T MR-linac using a standard clinical TRUFI sequence at a single institution. [PDF]

J Appl Clin Med Phys
Khalifa MA, Ma T, Aljuaid H, Kim S, Song WY.   +4 more
europepmc   +1 more source

FUNDAMENTAL STUDY OF CEREBRAL BLOOD FLOW IMAGING WITH SINGLE-PHOTON-EMISSION COMPUTED TOMOGRAPHY. : COMPARISON AMONG PHANTOM IMAGES USING ^<123>I PRODUCED BY THE (p, 2n) OR (p, 5n) REACTION AND ^<99m>Tc NUCLIDE

, 1987
Shinichi Yanagimoto, T Tomomitsu, Hiroaki Mimura, Naomasa Narihiro, Koushi Ishii, Hiroo Hiji   +5 more
openalex   +2 more sources

The IFNγ‐CIITA‐MHC II axis modulates melanoma cell susceptibility to NK‐cell‐mediated cytotoxicity

Molecular Oncology, EarlyView.
Natural killer (NK) cells play a central role in anti‐melanoma immunity. However, melanoma cells adapt during co‐culture by upregulating CIITA and MHC II in response to interferon gamma (IFNγ), thereby evading NK‐cell lysis. Blocking IFNγ signaling or treatment with dimethyl fumarate/simvastatin counteracts this immune escape and maintains NK‐cell ...
Lena C. M. Krause, Rixa‐Mareike Köhn, Christian Ickes, Julia Lenger, Jonas Fischer, Sabrina Cappello, Ivan Bogeski   +6 more
wiley   +1 more source