Results 121 to 130 of about 15,514 (184)
Evidence of Involvement of the Calcitonin Gene‐Related Peptide in Restless Legs Syndrome
Movement Disorders, EarlyView.Abstract Background Restless legs syndrome (RLS) is a common sensory‐motor disorder characterized by an urge to move the legs, often with unpleasant sensations, particularly during rest. Current treatments include iron supplementation, dopamine agonists, and opioids, but new therapeutic approaches are needed.
Maria P. Mogavero +8 more
wiley +1 more source
Movement Disorders, EarlyView.Abstract Background Pallidal neurostimulation is an effective treatment for severe isolated dystonia, but long‐term data from clinical trials are lacking. Objectives To evaluate long‐term efficacy and safety of pallidal neurostimulation in patients with isolated generalized or segmental dystonia.
Patricia Krause +60 more
wiley +1 more source
Definition and Classification of Dystonia
Movement Disorders, EarlyView.Abstract Dystonia is a movement disorder with varied clinical features and diverse etiologies. Here we present a revision of the 2013 consensus definition and classification of dystonia in light of subsequent publications and experience with its application during the last decade.
Alberto Albanese +13 more
wiley +1 more source
Molecular Nutrition &Food Research, EarlyView.(Poly)phenols constitute a source of natural therapeutic molecules capable of targeting angiogenesis in different scenarios. This review summarizes the current evidence of the role of (poly)phenols in modulating angiogenesis. The reader can find a compilation of preclinical and human investigations describing pro‐ and anti‐angiogenic effects of these ...
María Ángeles Ávila‐Gálvez +5 more
wiley +1 more source
Muscle &Nerve, EarlyView.ABSTRACT Amyotrophic lateral sclerosis (ALS) is a progressive neurodegenerative disease that has no cure, and treatments predominantly focus on improving quality of life. Patient‐centred care is central to bringing about meaningful improvements to quality of life.
A. Clift +4 more
wiley +1 more source
Muscle &Nerve, EarlyView.ABSTRACT Introduction/Aims Sevasemten (EDG‐5506) is an orally administered, investigational small molecule that selectively modulates fast muscle fiber contraction by inhibiting fast myosin ATPase. This study assessed the safety, tolerability, and pharmacokinetics (PK)/pharmacodynamics (PD) of sevasemten in healthy adult volunteers (HVs) and adults ...
Joanne Donovan +11 more
wiley +1 more source
Function of the Normal Neuromuscular Junction in Young Children
Muscle &Nerve, EarlyView.ABSTRACT Introduction/Aims The repetitive nerve stimulation (RNS) test is fundamental to test the functional integrity of the neuromuscular junction. RNS data are scarce for newborns and young children, limiting early diagnostic efforts to identify children with neuromuscular diseases. Here, we performed RNS in young children.
Márk Kozák +6 more
wiley +1 more source
Multi‐Frequency Electrical Impedance Myography as a Predictor of Muscle Function in Older Adults
Muscle &Nerve, EarlyView.ABSTRACT Introduction/Aims This study examined the potential of multi‐frequency electrical impedance myography (EIM) to predict hand grip strength (HGS) variability among adults, including a large proportion of older adults, with and without sarcopenia.
Niladri Kumar Mahato +4 more
wiley +1 more source