Results 111 to 120 of about 1,779,855 (302)

Identification of a Shiga toxin A‐derived peptide internalized into Gb3 receptor‐bearing cells via interaction with the Shiga toxin B subunit

FEBS Letters, EarlyView.
The process of internalization of the Shiga toxin A subunit via formation of a complex with the Shiga toxin B subunit, which specifically binds to the Gb3 receptor. The peptide is designed to act as a carrier of drugs into cancer cells. Here, we explored the potential of peptides derived from the catalytic A subunit of Shiga toxin (STxA) to be drug ...
Giulia Opassi, João C. Encarnação, Valeria Napolitano, Grzegorz Dubin, Grzegorz Popowicz, Karl Andersson, U. Helena Danielson   +6 more
wiley   +1 more source

Biomimetic 3D-printed neurovascular phantoms for near-infrared fluorescence imaging

, 2018
Emerging three-dimensional (3D) printing technology enables the fabrication of optically realistic and morphologically complex tissue-simulating phantoms for the development and evaluation of novel optical imaging products.
Pejhman Ghassemi, Jianting Wang, T. Joshua Pfefer, Yu Chen, Andrew Depkon, Qinggong Tang, Yi Liu, Maria Ida Iacono, Jonathan Lin, Gonzalo Mendoza   +9 more
core   +1 more source

A Comprehensive Evaluation of 3D-Printed Breast Phantoms: Impacts of Printing Technology and STL Processing on Multimodal Fidelity

Technologies
Anthropomorphic breast phantoms are increasingly used for the development and evaluation of breast imaging technologies. The aim of this study is to evaluate the impacts of the material combination and stereolithography or Standard Tessellation Language (
Nikolay Dukov, Vencislav Nastev, Viktoria Petkova, Ivan Buliev, Zhivko Bliznakov, Valentina Dobreva, Kristina Bliznakova   +6 more
doaj   +1 more source

Multi-energy computed tomography breast imaging with Monte Carlo simulations: Contrast-to-noise-based image weighting

Journal of Medical Physics, 2019
Context: Photon-counting detectors and breast computed tomography imaging have been an active area of research. With these detectors, photons are assigned an equal weight and weighting schemes can be enabled. More weight can be assigned to lower energies,
Déte Van Eeden, Freek C. P Du Plessis
doaj   +1 more source

Investigating transcription factor dynamics in health and disease using FRAP

FEBS Letters, EarlyView.
FRAP analysis of GFP‐tagged transcription factors reveals how molecular mobility and target engagement change in response to drug treatment. By combining live‐cell imaging, quantitative model fitting, and statistical analysis, this approach uncovers transcription factor dynamics linked to disease mechanisms, providing a powerful framework for ...
Kannan Govindaraj, Carolina Vazquez Garzon, Jose Joaquin Velasco, Janine N. Post   +3 more
wiley   +1 more source

Phantom design for tracked ultrasound-based surgical navigation systems

MethodsX
For pediatric oncology patients, radical tumor removal is crucial. Surgical navigation using tracked ultrasound may improve radical removal rates in pediatric surgery, based on positive clinical outcomes in adult tumor surgery.
V.J. van Boheemen, J.M. van der Zee, M. Kuipers, M. Fitski, M.H.W.A. Wijnen, F.J. Siepel, A.F.W. van der Steeg   +6 more
doaj   +1 more source

Microbiome‐blood–brain barrier interactions in aging — mechanisms and therapeutic potential

FEBS Letters, EarlyView.
Aging reshapes the gut microbiome (↓SCFA‐producing commensals; ↑pro‐inflammatory outputs), shifting circulating metabolites (↓SCFAs; ↑LPS, ↑TMAO, ↑PAA) that act at the BBB to increase nonspecific transcytosis, alter transport, and promote astrocyte reactivity, heightening brain vulnerability.
Daniel Cuervo‐Zanatta, Hari Baskar Balasubramanian, Amir Pasokh, Marietta Zille   +3 more
wiley   +1 more source

Advancements in Microwave Bone Imaging: Tomographic Reconstruction of an Anthropomorphic Calcaneus Phantom Using a Specialized Imaging Prototype for Bone Health Applications

IEEE Access
The evaluation and characterization of microwave imaging (MWI) prototype along with the optimization of imaging algorithm is a precursor step before the clinical study to measure in vivo dielectric properties.
Alessia Cannata, Adnan Elahi, Martin O'Halloran, Marco Pasian, Simona Di Meo, Giulia Matrone, Bilal Amin   +6 more
doaj   +1 more source

An epithelial GPR35 isoform supports tumor‐associated transcriptional and metabolic phenotypes

FEBS Letters, EarlyView.
GPR35 generates two functionally distinct isoforms with previously unresolved roles. GPR35‐short mediates immune‐cell chemotaxis, while GPR35‐long is enriched in colorectal cancer epithelium, where it supports increased metabolism, proliferation, and tumor‐associated transcriptional programs.
Jørgen D. Rønneberg, Martine Hjeltnes, Josephine Krieger, Joshua E. Elias, Maria Stensland, Kristian Holm, Xiaojun Jiang, Chuki Khangsar, Tuula A. Nyman, Arthur Kaser, Johannes R. Hov, Tom H. Karlsen, Nicole C. Kaneider, Frode L. Jahnsen, Georg Schneditz   +14 more
wiley   +1 more source

Super-contrast photoacoustic resonance imaging

, 2018
In this paper, a new imaging modality, named photoacoustic resonance imaging (PARI), is proposed and experimentally demonstrated. Being distinct from conventional single nanosecond laser pulse induced wideband PA signal, the proposed PARI method utilizes
Siyu Liu, Gao, Fei, Yuanjin Zheng, Zhang, Ruochong, Xiaohua Feng, Feng, Xiaohua, Liu, Siyu, Ruochong Zhang, Fei Gao, Zheng, Yuanjin   +9 more
core   +1 more source