Results 91 to 100 of about 65,250 (291)

The ubiquitin ligase RNF115 is required for the clearance of damaged lysosomes

FEBS Letters, EarlyView.
Upon lysosomal rupture, an E3 ubiquitin ligase RNF115 translocates from the cytosol to the damaged lysosomal membrane. Moreover, RNF115 depletion impairs the clearance of damaged lysosomes, identifying it as a key regulator of lysosomal quality control.
Sae Nakanaga, Toshiki Takahashi, Akiko Kuma, Hiroyuki Kawahara   +3 more
wiley   +1 more source

Development and application of a set of mesh-based and age-dependent Chinese family phantoms for radiation protection dosimetry: Preliminary Data for external photon beams

EPJ Web of Conferences, 2017
A group of mesh-based and age-dependent family phantoms for Chinese populations were developed in this study. We implemented a method for deforming original RPI-AM and RPI-AF models into phantoms of different ages: 5, 10 ,15 and adult.
Pi Yifei, Zhang Lian, Huo Wanli, Feng Mang, Chen Zhi, Xu X. George   +5 more
doaj   +1 more source

Designing microarray phantoms for hyperspectral imaging validation

Biomedical Optics Express, 2012
The design and fabrication of custom-tailored microarrays for use as phantoms in the characterization of hyperspectral imaging systems is described. Corresponding analysis methods for biologically relevant samples are also discussed. An image-based phantom design was used to program a microarrayer robot to print prescribed mixtures of dyes onto ...
Clarke, Matthew L., Lee, Ji Youn, Samarov, Daniel V., Allen, David W., Litorja, Maritoni, Nossal, Ralph, Hwang, Jeeseong   +6 more
openaire   +2 more sources

Organizing the interface—Plasma membrane architecture and receptor dynamics in virus‐cell interactions

FEBS Letters, EarlyView.
Plasma membranes contain dynamic nanoscale domains that organize lipids and receptors. Because viruses operate at similar scales, this architecture shapes early infection steps, including attachment, receptor engagement, and entry. Using influenza A virus and HIV‐1 as examples, we highlight how receptor nanoclusters, multivalent glycan interactions ...
Jan Schlegel, Christian Sieben
wiley   +1 more source

In vitro models of cancer‐associated fibroblast heterogeneity uncover subtype‐specific effects of CRISPR perturbations

Molecular Oncology, EarlyView.
Development of therapies targeting cancer‐associated fibroblasts (CAFs) necessitates preclinical model systems that faithfully represent CAF–tumor biology. We established an in vitro coculture system of patient‐derived pancreatic CAFs and tumor cell lines and demonstrated its recapitulation of primary CAF–tumor biology with single‐cell transcriptomics ...
Elysia Saputra, Shamsudheen Karuthedath Vellarikkal, Lixia Li, Hong Sun, Khoa Nguyen, Amber Montano, Suchitra Natarajan, Federica Piccioni, Alex Michael Tamburino, Xin Yu, Aleksandra Katarzyna Olow   +10 more
wiley   +1 more source

Phantom design for tracked ultrasound-based surgical navigation systems

MethodsX
For pediatric oncology patients, radical tumor removal is crucial. Surgical navigation using tracked ultrasound may improve radical removal rates in pediatric surgery, based on positive clinical outcomes in adult tumor surgery.
V.J. van Boheemen, J.M. van der Zee, M. Kuipers, M. Fitski, M.H.W.A. Wijnen, F.J. Siepel, A.F.W. van der Steeg   +6 more
doaj   +1 more source

In vivo characterization of connective tissue remodeling using infrared photoacoustic spectra [PDF]

, 2018
Premature cervical remodeling is a critical precursor of spontaneous preterm birth, and the remodeling process is characterized by an increase in tissue hydration.
Alisio, Mariana, Altieri, Emma, Anderson, Monica, Barber, Sabrina, Burger, Tracy, Chubiz, Jessica, Diveley, Emily, England, Sarah K, Garcia-Uribe, Alejandro, Goldstein, Naomi, Helm, Kristi, Hu, Peng, Kramer, Christine, Li, Chiye, Ma, Jun, Macones, George A, Maslov, Konstantin, Maynard, Jennifer, McCarthy, Ronald, Meyenburg, Kaytelyn, Meyers, Karen, Muench, Lisa, Onwumere, Oji, Pizzella, Stephanie, Punyamurthy, Nina, Qu, Yuan, Shi, Junhui, Slaughter, Janessia, Stout, Molly J, Tuuli, Methodius, Wang, Lihong V, Zhao, Peinan   +31 more
core   +1 more source

Exploiting metabolic adaptations to overcome dabrafenib treatment resistance in melanoma cells

Molecular Oncology, EarlyView.
We show that dabrafenib‐resistant melanoma cells undergo mitochondrial remodeling, leading to elevated respiration and ROS production balanced by stronger antioxidant defenses. This altered redox state promotes survival despite mitochondrial damage but renders resistant cells highly vulnerable to ROS‐inducing compounds such as PEITC, highlighting redox
Silvia Eller, Susanne Ebner, Carmen Haselrieder, Julia K. Günther, Astrid Drasche, Sophie Strich, Chiara Volani, Andrea Medici, Aleksandar Nikolajevic, Alex Deltedesco, Johannes E. Sigmund, Michael J. Blumer, Martin Hermann, Johanna Vanacker, Gerald Brandacher, Eduard Stefan, Omar Torres‐Quesada, Jakob Troppmair   +17 more
wiley   +1 more source

Advancements in Microwave Bone Imaging: Tomographic Reconstruction of an Anthropomorphic Calcaneus Phantom Using a Specialized Imaging Prototype for Bone Health Applications

IEEE Access
The evaluation and characterization of microwave imaging (MWI) prototype along with the optimization of imaging algorithm is a precursor step before the clinical study to measure in vivo dielectric properties.
Alessia Cannata, Adnan Elahi, Martin O'Halloran, Marco Pasian, Simona Di Meo, Giulia Matrone, Bilal Amin   +6 more
doaj   +1 more source

Tissue-like phantoms for quantitative birefringence imaging

Biomedical Optics Express, 2017
Birefringence imaging, including polarization sensitive optical coherence tomography (PS-OCT), can provide valuable insight into the microscopic structure and organization of many biological tissues. In this paper, we report on a method to fabricate tissue-like birefringence phantoms for such imaging modalities.
Liu, Xinyu, Beaudette, Kathy, Wang, Xianghong, Liu, Linbo, Bouma, Brett E., Villiger, Martin   +5 more
openaire   +4 more sources