Results 171 to 180 of about 65,250 (291)

The cooperative regulation of miR‐221 by APE1 and AUF1 impacts p27Kip1 defining a miR signature relevant for cervical cancer

FEBS Open Bio, EarlyView.
A regulatory axis involving APE1, AUF1, and miR‐221 is proposed. Pri‐miR‐221 is processed by DROSHA and DICER to generate mature miR‐221, which targets p27Kip1 mRNA. APE1 and AUF1 compete for pre‐miR‐221 binding. Reduced APE1/AUF1 levels impair miR‐221 biogenesis, decrease p27Kip1 mRNA degradation, and promote cell cycle progression, chemoresistance ...
Matilde Clarissa Malfatti, Nicolò Gualandi, Gianluca Tell, Giulia Antoniali   +3 more
wiley   +1 more source

Data-Driven System Matrix Manipulation Enabling Fast Functional Imaging in Tomography. [PDF]

IEEE Trans Med Imaging
Hu P, Tong X, Lin L, Wang LV.
europepmc   +1 more source

Anchorage‐independent and faster growth in clonal population from UV‐irradiated NER‐deficient cells

FEBS Open Bio, EarlyView.
UV‐irradiated cells expressing a DDB2 mutant protein unable to interact with PCNA (DDB2PCNA‐) form clones able to grow without anchorage. Different experimental approaches reveal heterogeneity in cell cycle regulation and drug response within these clones, emphasizing the crucial role of the DDB2‐PCNA interaction in preventing cellular transformation ...
Paola Perucca, Anna Tricarico, Martina Furfaro, Priyam Ghosh, Ennio Prosperi, Lucia Anna Stivala, Ornella Cazzalini   +6 more
wiley   +1 more source

Determination of Finger Optical Properties Using an Integrating Sphere. [PDF]

Sensors (Basel)
Wagner M, Beutel B, Naglic P, Fugger O, Foschum F, Kienle A.   +5 more
europepmc   +1 more source

A light‐triggered Time‐Resolved X‐ray Solution Scattering (TR‐XSS) workflow with application to protein conformational dynamics

FEBS Open Bio, EarlyView.
Time‐resolved X‐ray solution scattering captures how proteins change shape in real time under near‐native conditions. This article presents a practical workflow for light‐triggered TR‐XSS experiments, from data collection to structural refinement. Using a calcium‐transporting membrane protein as an example, the approach can be broadly applied to study ...
Fatemeh Sabzian‐Molaei, Fredrik Orädd, Konstantinos Magkakis, Magnus Andersson   +3 more
wiley   +1 more source

Computationally efficient x-ray simulation framework using parameterized material attenuation models in anatomically detailed imaging. [PDF]

Med Phys
Nassi M, Mikerov M, Michielsen K, Sechopoulos I.   +3 more
europepmc   +1 more source

PARP inhibitors induce a senescence phenotype in non‐small cell lung carcinoma cell lines

FEBS Open Bio, EarlyView.
Talazoparib is the most potent inducer of senescence among different PARP1 inhibitors in human NSCLC cells. In the absence of PARP, no senescence phenotype was observed, demonstrating that PARP1 is necessary for the induction of senescence by this inhibitor.
Camille Huart, Manon Van den Abbeel, Christoph Schifflers, Karim Bouhjar, Andrea Scarmelotto, Alexis Khelfi, Anne‐Catherine Wera, Carine Michiels   +7 more
wiley   +1 more source

Roadmap for light interaction with biophotonic surfaces and their diverse applications. [PDF]

J Biomed Opt
Władziński A, Meglinski I, Bykov A, Gritsevich M, Kryuchkov M, Katanaev VL, Dragoi B, Pop N, Kwon J, Fernandes SN, Godinho MH, Chalkidis SG, Vougioukalakis GC, Bones AM, Wróbel MS, Karpienko K, Władzińska M, Sokołowski P, Novikova T, Ramella-Roman JC, Stergar J, Simončič U, Milanič M, Vuković N, Radovanović J, Demić A, Inđjin D, Gnyba M, Szczerska M.   +28 more
europepmc   +1 more source

Single‐molecule DNA flow‐stretch assays for high‐throughput DNA–protein interaction studies

FEBS Open Bio, EarlyView.
We describe an optimised single‐molecule DNA flow‐stretch assay that visualises DNA–protein interactions in real time. Linear DNA fragments are tethered to a surface and stretched by buffer flow for fluorescence imaging. Using λ and φX174 DNA, this protocol enhances reproducibility and accessibility, providing a versatile approach for studying diverse ...
Ayush Kumar Ganguli, Mohammad Nour Alsamsam, Ugnė Bagdonaitė, Van Truc Vu, Chun‐Jen Huang, Polina Kuzhir, Mindaugas Zaremba, Aurimas Kopūstas, Marijonas Tutkus   +8 more
wiley   +1 more source

In vivo imaging of metabolic heterogeneity across three endpoints relevant to aggressive breast cancer. [PDF]

PNAS Nexus
D'Agostino VW, Kwan M, Yong A, Grossman K, Sunassee ED, Madonna MC, Hirschey M, Palmer GM, Ramanujam N.   +8 more
europepmc   +1 more source