Results 231 to 240 of about 57,882 (315)

Proteasomal degradation of intracellularly expressed Amblyomin‐X limits suicide gene therapy potential in melanoma cells

FEBS Open Bio, EarlyView.
This study explores the feasibility of expressing the antitumoral protein Amblyomin‐X through a suicide gene therapy approach and investigates its intracellular fate after gene delivery. Although the gene is efficiently expressed, melanoma cells rapidly degrade the Amblyomin‐X protein via proteasome activity.
Victor Dal Posolo Cinel, Carlos DeOcesano Pereira, Aline Ramos Maia Lobba, Melissa Regina Fessel, Ana Marisa Chudzinski‐Tavassi   +4 more
wiley   +1 more source

Visual appearance of blood vessels: a phantom study. [PDF]

Biomed Opt Express
Wagner M, Hevisov D, Konrad C, Schmidt H, Foschum F, Kienle A.   +5 more
europepmc   +1 more source

Decreased cold‐sensing function of the transient receptor potential channel TRPM8 from tailed amphibians

FEBS Open Bio, EarlyView.
Despite frogs avoiding low temperatures, examination of four salamander species revealed that none avoided cold and all possessed cold tolerance. Functional analysis of TRPM8, a cold sensor, showed that all salamander TRPM8s had lost their cold sensitivity.
Tadahiro Sawao, Daiki Kobayashi, Shogo Hori, Osamu Saitoh   +3 more
wiley   +1 more source

Mimicking Tissues in 3D-Printed Radiology Phantoms: Brand, Product, and Color of Printing Filaments Matter! [PDF]

Polymers (Basel)
Hofmann T, Buschmann M, Belarra A, Castillo-Garcia M, Chevalier M, Hernandez-Giron I, Homolka P.   +6 more
europepmc   +1 more source

Evolutionarily divergent DUF4465 domains have a common vitamin B12‐binding function

FEBS Open Bio, EarlyView.
We show that DUF4465 family proteins, widespread across bacteria from gut microbiomes, hydrothermal vents, and soil, share a common vitamin B12‐binding function. These augmented β‐jellyroll proteins bind vitamin B12 via extended loops. Our findings establish sequence‐diverse DUF4465 proteins as a widespread class of B12‐binding proteins, highlighting ...
Charlea Clarke, Michal Banasik, Rokas Juodeikis, Martin J. Warren, Richard W. Pickersgill   +4 more
wiley   +1 more source

CUCT-Net: End-to-End Signal-to-Image Learning for Quantized Speed-of-Sound Estimation and Tissue Segmentation in Ultrasound Computed Tomography. [PDF]

Sensors (Basel)
Gao Q, Almekkawy MK.
europepmc   +1 more source

The skills required for transition to university and study in biological sciences: A student perspective

FEBS Open Bio, EarlyView.
Bioscience students were asked for their opinions on the value and teaching of skills. 204 responded that teamwork, time management and study skills are necessary to reach University, that scientific writing, research, laboratory and presentation skills are taught effectively during their studies, while other skills are gained inherently through study ...
Janella Borrell, Susan Crennell
wiley   +1 more source

Estimation of Detailed Cardiac Doses for Pediatric Radiation Therapy Patients in National Wilms Tumor Study. [PDF]

Int J Radiat Oncol Biol Phys
Lee C, Mille MM, Griffin KT, Rigsby C, Popescu A, Gopalakrishnan M, Leisenring W, Peterson S, Dome JS, Laurie F, Fitzgerald TJ, Bentzen S, Jung JW, Lee C, Kalapurakal JA.   +14 more
europepmc   +1 more source

Mass spectrometry based identification of AMP‐O‐Tris generated by Thermococcus onnurineus Cas10

FEBS Open Bio, EarlyView.
Isolated Thermococcus onnurineus Cas10 generates the noncanonical ATP‐derived product AMP‐O‐Tris while in Tris‐containing buffer as identified via mass spectrometry, revealing relaxed nucleophile selectivity under isolated conditions. These findings suggest that multiprotein Csm complex assembly restricts Cas10 reactivity toward canonical cyclic ...
Su‐Jin Lee, Ga Seul Lee, JinHan Kim, Kwang‐Hyun Park, Seong‐Ryung Go, Jeong Hee Moon, Eui‐Jeon Woo   +6 more
wiley   +1 more source

A phantom mimicking layered biological microenvironments investigated with 7T diffusion weighted MRI. [PDF]

Sci Rep
Łabieniec Ł, Szymański K, Wieteska M, Domański G, Brancewicz M, Lisowski Ł, Lipiński K, Łaźny R, Bogorodzki P.   +8 more
europepmc   +1 more source