CDT1 is an essential protein for DNA replication licensing that loads the MCM complex, the eukaryotic replicative DNA helicase, onto replication origins. Overexpression of CDT1 induces cell cycle arrest at the S phase. Here we showed CDT1 inhibits the progression of replication forks by interacting with the MCM complex, leading to the stalling and ...
Takashi Tsuyama +7 more
wiley +1 more source
Yearbook of Pharmacy comprising abstracts of papers relating to Pharmacy, Materia medica and Chemistry contributed to British and foreign journals, from 1. July 1875—30. June 1876, with the Transactions of the British Pharmaceutical conference at the 13. annual meeting, held in Glasgow, Septbr. 1876. London: J. & A. Churchill [PDF]
F. Elsner
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Molecular determinants of signal transduction in tropomyosin receptor kinases
Tropomyosin receptor kinases control critical neuronal functions, but how do the same receptors produce diverse cellular responses? This review explores the structural mechanisms behind Trk signaling diversity, focusing on allosteric modulation and ligand bias.
Giray Enkavi
wiley +1 more source
Card games are effective tools to enhance foundation year health and safety inductions
A series of three card games was developed to actively deliver health and safety education to foundation year students. Most students reported positive responses regarding their enjoyment (89.9 %) and learning (74.7 %) from all games evaluated. Data revealed significant improvements in health and safety knowledge (P < 0.0001).
Rumana Rafiq +4 more
wiley +1 more source
Anxiety disorders, depression and pain are highly prevalent pathologies. Their pharmacotherapy is associated with unwanted side effects; hence there is a clinical need to develop more effective drugs with fewer adverse reactions.Chalcones are one of the ...
Josefina Higgs +8 more
doaj +1 more source
Yearbook of Pharmacy comprising abstracts of papers relating to Pharmacy, Materia medica, and Chemistry, contributed to British and foreign Journals, with the Transactions of the British Pharmaceutical Conference at the tenth annual meeting held at Bratford, September 1873 [PDF]
F. Elsner
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This study addressed how a senior research thesis is perceived by undergraduate students. It assessed students' perception of research skills, epistemological beliefs, and career goals in Biochemistry (science) and BDC (science‐business) students. Completing a thesis improved confidence in research skills, resilience, scientific identity, closed gender‐
Celeste Suart +4 more
wiley +1 more source
The Pharmacopœial Requirements for Cannabis Sativa**Presented to the Division of Pharmaceutical Chemistry of the American Chemical Society. [PDF]
Herbert C. Hamilton
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