Results 71 to 80 of about 1,889,609 (335)
Key Green Chemistry research areas from a pharmaceutical manufacturers’ perspective revisited
, 2018 In 2007 the members of the ACS Green Chemistry Institute® Pharmaceutical Roundtable assembled a list of key green chemistry research areas to both identify transformations that would benefit from improvements in process greenness and to encourage ...
M. Bryan +13 more
semanticscholar +1 more source
Molecular Oncology, EarlyView.We identify USP29 as the only DUB mirroring CA9 expression, a marker of hypoxia and HIF pathway activation associated with PCA aggressiveness. USP29 stabilizes HIF‐1α and HIF‐2α via a noncanonical mechanism that is independent of PHD/pVHL activity yet relies on proteasomal regulation, establishing USP29 as a previously unrecognized regulator of hypoxic
Amelie S Schober +16 more
wiley +1 more source
Molecular Oncology, EarlyView.BCL9 and BCL9L drive bladder cancer progression by enhancing β‐catenin signaling, promoting proliferation, migration, invasion, and organoid growth. Genetic depletion of BCL9(L) suppresses malignant phenotypes, while pharmacological disruption of the β‐catenin/BCL9(L) complex with ZW4864 inhibits canonical Wnt signaling and tumor‐associated cellular ...
Roland Kotolloshi +11 more
wiley +1 more source
Heliyon, 2016 Objectives: Microfluidic perfusion systems are used for assessing cell and tissue function while assuring cellular viability. Low perfusate flow rates, desired both for conserving reagents and for extending the number of channels and duration of ...
Austin Rountree +5 more
doaj +1 more source
Principles of green chemistry: building a sustainable future
Discover ChemistryGreen chemistry is an interdisciplinary field that focuses on minimizing hazardous substances and promoting sustainable alternatives in chemical processes to conventional chemical processes and products.
F. Kurul, Beyzanur Doruk, S. N. Topkaya
semanticscholar +1 more source
Anais da Academia Brasileira de Ciências, 2018 We present a comprehensive review of the advent and impact of continuous flow chemistry with regard to the synthesis of natural products and drugs, important pharmaceutical products and definitely responsible for a revolution in modern healthcare.
J. M. D. Souza +6 more
semanticscholar +1 more source
Promiscuous stimulation of HSP70 ATPase activity by parasite‐derived J‐domains
FEBS Open Bio, EarlyView.The malaria parasite Plasmodium falciparum exports three highly homologous yet functionally divergent J‐domain proteins into human erythrocytes. Here, we show that J‐domains isolated from all three proteins effectively stimulate the ATPase activity of both endogenous host and exported parasite HSP70 chaperones.
Julian Barth +6 more
wiley +1 more source
A comparative study of the patentability standards with respect to pharmaceutical inventions in the United Kingdom and South Africa [PDF]
, 2014 Using a comparative methodology the thesis analyses the patentability of pharmaceutical and related inventions in the UK and South Africa. The viewpoint adopted is that of the industry actors, who are engaged in the conception through to the ...
Dludlu, Celucolo Peter
core
Chemistry, Synthesis, and Structure Activity Relationship of Anticancer Quinoxalines
, 2023 Quinoxaline is a fused heterocycle system of a benzene ring and pyrazine ring. It has earned considerable attention due to its importance in the field of medicinal chemistry.
Mohamed F. Zayed
core +1 more source
Salmon cartilage proteoglycan promotes the healing process of Staphylococcus aureus-infected wound
Heliyon, 2018 Wound healing is the critical event for maintaining skin function and barrier. Inflammatory state in which a variety of cells are activated and accumulated is important for wound healing.
Shouhei Hirose +3 more
doaj +1 more source