Results 21 to 30 of about 557,783 (345)

A user-friendly Matlab program and GUI for the pseudorotation analysis of saturated five-membered ring systems based on scalar coupling constants [PDF]

, 2008
Background: The advent of combinatorial chemistry has revived the interest in five-membered heterocyclic rings as scaffolds in pharmaceutical research. They are also the target of modifications in nucleic acid chemistry.
Hendrickx, Pieter, Martins, José
core   +4 more sources

Synthesis and biological activity of fused tetracyclic Pyrrolo[2,1-c][1,4]benzodiazepines

Heliyon, 2018
Cancer remains the second major cause of death in the world. Thus, there is a pressing need to identify potential synthetic route for the development of novel anticancer agents which will serve as lead compounds to effectively combat this life ...
Joel K. Annor-Gyamfi, John M. Jarrett, Joseph O. Osazee, Dobrusia Bialonska, Crystal Whitted, Victoria E. Palau, Abbas G. Shilabin   +6 more
doaj   +1 more source

Development of a validated RP-HPLC/DAD method for the quantitative determination of methyl jasmonate in an insect repellent semi-solid formulation

Heliyon, 2019
A simple and efficient reversed-phase high-performance liquid chromatographic (RP-HPLC) method has been developed for the first time for the estimation of a mosquito repellent, methyl jasmonate in a cream formulation, and validated as per the ...
Johirul Islam, Saurav Phukan, Pronobesh Chattopadhyay   +2 more
doaj   +1 more source

New spectral resolution techniques for resolving and determining the components in binary fixed-dose combinations

Heliyon, 2019
Four spectrophotometric approaches were performed to determine a binary combination of Phenazone and Benzocaine in pure powder form and in pharmaceutical formations. This investigation submits the application of four techniques contingent on the presence
Duaa J. Al Zakri, Reem H. Obaydo, Amir Alhaj Sakur   +2 more
doaj   +1 more source

Development and validation of eco-friendly micellar-HPLC and HPTLC-densitometry methods for the simultaneous determination of paritaprevir, ritonavir and ombitasvir in pharmaceutical dosage forms

Heliyon, 2019
Ombitasvir, ritonavir and paritaprevir are three recently discovered directly acting antiviral drugs (DAADs) used in combined single dose tablet dosage form for treatment of hepatitis-C viral infections (HCV).
Adel Ehab Ibrahim, Roshdy E. Saraya, Hanaa Saleh, Magda Elhenawee   +3 more
doaj   +1 more source

Voltammetric determination of paracetamol in tablet formulation using Fe (III) doped zeolite-graphite composite modified GCE

Heliyon, 2019
Although paracetamol is known to have excellent safety profile at recommended therapeutic doses, health effects are also reported at acute overdoses.
Meareg Amare
doaj   +1 more source

Auto In Silico Ligand Directing Evolution to Facilitate the Rapid and Efficient Discovery of Drug Lead

iScience, 2020
Summary: Motivated by the growing demand for reducing the chemical optimization burden of H2L, we developed auto in silico ligand directing evolution (AILDE, http://chemyang.ccnu.edu.cn/ccb/server/AILDE), an efficient and general approach for the rapid ...
Fengxu Wu, Linsheng Zhuo, Fan Wang, Wei Huang, Gefei Hao, Guangfu Yang   +5 more
doaj   +1 more source

Direct measurement of molecular mobility and crystallisation of amorphous pharmaceuticals using terahertz spectroscopy. [PDF]

, 2016
Despite much effort in the area, no comprehensive understanding of the formation and behaviour of amorphous solids has yet been achieved. This severely limits the industrial application of such materials, including drug delivery where, in principle ...

core   +2 more sources

Design, synthesis and biological evaluation of benzoxazolinone-containing 1,3,4-thiadiazoles as TNF-α inhibitors

Heliyon, 2019
A library of nineteen benzoxazolinone-based 1,3,4-thiadiazoles has been synthesized and screened for their anti-inflammatory activity. The compound 1f exhibited a potent anti-inflammatory activity with an inhibition of 65.83% and 32.50% after 3 h and 5 h
Saqlain Haider, Mohammad Sarwar Alam, Hinna Hamid, Abhijeet Dhulap, Deepak Kumar   +4 more
doaj   +1 more source

4‐nitrobenzoate inhibits 4‐hydroxybenzoate polyprenyltransferase in malaria parasites and enhances atovaquone efficacy

FEBS Letters, EarlyView.
Atovaquone is an antimalarial requiring potentiation for sufficient efficacy. We pursued strategies to enhance its activity, showing that 4‐nitrobenzoate inhibits 4‐hydroxybenzoate polyprenyltransferase, decreasing ubiquinone biosynthesis. Since atovaquone competes with ubiquinol in mitochondria, 4‐nitrobenzoate facilitates its action, potentiating ...
Ignasi Bofill Verdaguer, Matheus Felipe Santos, Maurício Mazzine Filho, Gabriela Oliveira Castro, Agustín Hernández, Manoel Aparecido Peres, Alejandro Miguel Katzin, Marcell Crispim   +7 more
wiley   +1 more source