Results 31 to 40 of about 263,756 (296)

Blending problem-based learning and peer-led team learning, in an open ended ‘home-grown’pharmaceutical chemistry case study [PDF]

open access: yes, 2018
Pharmaceutical chemistry, medicinal chemistry and the drug discovery process require experienced practitioners to employ reasoned speculation in generating creative ideas, which can be used to evolve promising molecules into drugs.
Veale, Clinton G L   +5 more
core   +2 more sources

Voltammetric determination of paracetamol in tablet formulation using Fe (III) doped zeolite-graphite composite modified GCE

open access: yesHeliyon, 2019
Although paracetamol is known to have excellent safety profile at recommended therapeutic doses, health effects are also reported at acute overdoses.
Meareg Amare
doaj   +1 more source

Development and validation of eco-friendly micellar-HPLC and HPTLC-densitometry methods for the simultaneous determination of paritaprevir, ritonavir and ombitasvir in pharmaceutical dosage forms

open access: yesHeliyon, 2019
Ombitasvir, ritonavir and paritaprevir are three recently discovered directly acting antiviral drugs (DAADs) used in combined single dose tablet dosage form for treatment of hepatitis-C viral infections (HCV).
Adel Ehab Ibrahim   +3 more
doaj   +1 more source

Auto In Silico Ligand Directing Evolution to Facilitate the Rapid and Efficient Discovery of Drug Lead

open access: yesiScience, 2020
Summary: Motivated by the growing demand for reducing the chemical optimization burden of H2L, we developed auto in silico ligand directing evolution (AILDE, http://chemyang.ccnu.edu.cn/ccb/server/AILDE), an efficient and general approach for the rapid ...
Fengxu Wu   +5 more
doaj   +1 more source

Chemistry, Synthesis, and Structure Activity Relationship of Anticancer Quinoxalines [PDF]

open access: yes, 2023
Quinoxaline is a fused heterocycle system of a benzene ring and pyrazine ring. It has earned considerable attention due to its importance in the field of medicinal chemistry.
Mohamed F. Zayed
core   +1 more source

Synthesis and biological activity of fused tetracyclic Pyrrolo[2,1-c][1,4]benzodiazepines

open access: yesHeliyon, 2018
Cancer remains the second major cause of death in the world. Thus, there is a pressing need to identify potential synthetic route for the development of novel anticancer agents which will serve as lead compounds to effectively combat this life ...
Joel K. Annor-Gyamfi   +6 more
doaj   +1 more source

Development of a validated RP-HPLC/DAD method for the quantitative determination of methyl jasmonate in an insect repellent semi-solid formulation

open access: yesHeliyon, 2019
A simple and efficient reversed-phase high-performance liquid chromatographic (RP-HPLC) method has been developed for the first time for the estimation of a mosquito repellent, methyl jasmonate in a cream formulation, and validated as per the ...
Johirul Islam   +2 more
doaj   +1 more source

A Bibliometric Analysis of Publications in Uremic Toxins From 1991 to 2024

open access: yesTherapeutic Apheresis and Dialysis, EarlyView.
ABSTRACT Background Uremic toxins are a growing area of research in nephrology, with significant implications in the progression and treatment of chronic kidney disease (CKD) and the management of end‐stage kidney disease (ESKD). This bibliometric analysis aims to evaluate the global research trends, key contributors, and the impact of publications in ...
Yuh‐Shan Ho   +7 more
wiley   +1 more source

Periodic DFT Calculations—Review of Applications in the Pharmaceutical Sciences [PDF]

open access: yes, 2020
In the introduction to this review the complex chemistry of solid-state pharmaceutical compounds is summarized. It is also explained why the density functional theory (DFT) periodic calculations became recently so popular in studying the solid APIs ...
Łukasz Szeleszczuk   +2 more
core   +1 more source

New spectral resolution techniques for resolving and determining the components in binary fixed-dose combinations

open access: yesHeliyon, 2019
Four spectrophotometric approaches were performed to determine a binary combination of Phenazone and Benzocaine in pure powder form and in pharmaceutical formations. This investigation submits the application of four techniques contingent on the presence
Duaa J. Al Zakri   +2 more
doaj   +1 more source

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