Results 31 to 40 of about 3,535,062 (289)

QSAR study of anti-Human African Trypanosomiasis activity for 2-phenylimidazopyridines derivatives using DFT and Lipinski's descriptors

Heliyon, 2019
The quantitative structure-activity relationship (QSAR) of sixty 2-phenylimidazopyridines derivatives with anti-Human African Trypanosomiasis (anti-HAT) activity has been studied by using the density functional theory (DFT) and statistical methods. Becke'
Samir Chtita, Mounir Ghamali, Abdellah Ousaa, Adnane Aouidate, Assia Belhassan, Abdelali Idrissi Taourati, Vijay Hariram Masand, Mohammed Bouachrine, Tahar Lakhlifi   +8 more
doaj   +1 more source

Design, synthesis and biological evaluation of benzoxazolinone-containing 1,3,4-thiadiazoles as TNF-α inhibitors

Heliyon, 2019
A library of nineteen benzoxazolinone-based 1,3,4-thiadiazoles has been synthesized and screened for their anti-inflammatory activity. The compound 1f exhibited a potent anti-inflammatory activity with an inhibition of 65.83% and 32.50% after 3 h and 5 h
Saqlain Haider, Mohammad Sarwar Alam, Hinna Hamid, Abhijeet Dhulap, Deepak Kumar   +4 more
doaj   +1 more source

Sample Preparation for Bioanalytical and Pharmaceutical Analysis [PDF]

, 2016
Biological and pharmaceutical samples represent formidable challenges in sample preparation that hold important consequences for bioanalysis and genotoxic impurity quantification. This Feature will emphasize significant advances toward the development of
Zheng, Cheng, Anderson, Jared, Cheng Zhang, Jared L. Anderson, Kevin D. Clark, Clark, Kevin   +5 more
core   +1 more source

Microwave assisted synthesis of coumarin-purine derivatives: An approach to in vitro anti-oxidant, DNA cleavage, crystal structure, DFT studies and Hirshfeld surface analysis

Heliyon, 2019
An easy and efficient microwave-assisted protocol has been developed for the synthesis of coumarin-purine hybrids (3a-3j). The newly constructed 1,3-dimethyl-7-((substituted)-2-oxo-2H-chromen-4-yl)methyl)-1H-purine-2,6(3H,7H)-dione derivatives were ...
Sumitra N. Mangasuli, Kallappa M. Hosamani, Praveen B. Managutti   +2 more
doaj   +1 more source

Voltammetric determination of paracetamol in tablet formulation using Fe (III) doped zeolite-graphite composite modified GCE

Heliyon, 2019
Although paracetamol is known to have excellent safety profile at recommended therapeutic doses, health effects are also reported at acute overdoses.
Meareg Amare
doaj   +1 more source

Horseradish peroxidase-catalyzed oxidation of rifampicin: Reaction rate enhancement by co-oxidation with anti-inflammatory drugs [PDF]

, 2005
The tuberculostatic drug rifampicin has been described as a scavenger of reactive species. Additionally, the recent demonstration that oral therapy with a complex of rifampicin and horseradish peroxidase (HRP) was more effective than rifampicin alone, in
Dos Santos, Fernanda de Jesus Notário, De Faria Oliveira, Olga Maria Mascarenhas, De Faria Oliveira, Olga Maria Mascarenhas [UNESP], Da Fonseca, Luiz Marcos [UNESP], Da Fonseca, Luiz Marcos, Ximenes, Valdecir Farias [UNESP], Brunetti, Iguatemy Lourenço [UNESP], Brunetti, Iguatemy Lourenço, Dos Santos, Fernanda de Jesus Notário [UNESP], Ximenes, Valdecir Farias   +9 more
core   +1 more source

Optimization of tris(2-carboxyethyl) phosphine reduction conditions for fast analysis of total biothiols in mouse serum samples

Heliyon, 2019
In this study, we investigated suitable conditions for the reduction of disulfides in mouse serum samples by tris(2-carboxyethyl) phosphine (TCEP) for fast analysis of total biothiols.
Chunfang Chang, Muneki Isokawa, Takashi Funatsu, Makoto Tsunoda   +3 more
doaj   +1 more source

Blending problem-based learning and peer-led team learning, in an open ended ‘home-grown’pharmaceutical chemistry case study [PDF]

, 2018
Pharmaceutical chemistry, medicinal chemistry and the drug discovery process require experienced practitioners to employ reasoned speculation in generating creative ideas, which can be used to evolve promising molecules into drugs.
Veale, Clinton G L, Joyce D. Sewry, Krause, Rui W M, Sewry, Joyce D, Clinton G. L. Veale, Rui W. M. Krause   +5 more
core   +1 more source

Featured Reviews in Organic Chemistry [PDF]

, 2023
The field of Organic Chemistry represents one of the most traditional areas of chemistry that has delivered many benefits to the community of chemists. This Special Issue of Molecules is a compilation of the most recent innovative developments in organic
Dembinski, Roman, Roman Dembinski, Vadim Soloshonok, Soloshonok, Vadym Anatolievch   +3 more
core   +1 more source

Development and validation of eco-friendly micellar-HPLC and HPTLC-densitometry methods for the simultaneous determination of paritaprevir, ritonavir and ombitasvir in pharmaceutical dosage forms

Heliyon, 2019
Ombitasvir, ritonavir and paritaprevir are three recently discovered directly acting antiviral drugs (DAADs) used in combined single dose tablet dosage form for treatment of hepatitis-C viral infections (HCV).
Adel Ehab Ibrahim, Roshdy E. Saraya, Hanaa Saleh, Magda Elhenawee   +3 more
doaj   +1 more source