Results 171 to 180 of about 666,519 (246)

Stability screening of pharmaceutical cocrystals

Pharmaceutical Development and Technology, 2021
An efficient protocol for assessing both the chemical and physical stability of cocrystalline forms of active pharmaceutical ingredients (APIs) is proposed. In this protocol, the cocrystalline material is used to prepare two standard formulations, mimicking wet granulations, to make low-dose tablets.
Kenneth C, Waterman, Alisa K, Waterman, Teslin M, Botoy, Jane, Li, Fenghe, Qiu, Michael, Hawley   +5 more
openaire   +2 more sources

Pharmaceutical Cocrystal Discovery via 3D-SMINBR: A New Network Recommendation Tool Augmented by 3D Molecular Conformations

Journal of Chemical Information and Modeling, 2023
Cocrystals have significant potential in various fields such as chemistry, material, and medicine. For instance, pharmaceutical cocrystals have the ability to address issues associated with physicochemical and biopharmaceutical properties.
Lulu Zheng, B. Zhu, Zengrui Wu, Mei Guo, Jin-yao Chen, Minghuang Hong, Guixia Liu, Weihua Li, Guo-bin Ren, Yun Tang   +9 more
semanticscholar   +1 more source

Novel pharmaceutical cocrystal of lenalidomide with nicotinamide: Structural design, evaluation, and thermal phase transition study.

International journal of pharmaceutics, 2021
Lenalidomide (LDM), widely used for the treatment of transfusion-dependent anaemia, has low oral bioavailability due to its poor aqueous solubility. Herein, we selected nicotinamide (NIC) as a coformer and synthesized a novel pharmaceutical cocrystal ...
Lijuan Wang, Yizhen Yan, Xiangyang Zhang, Xinggui Zhou   +3 more
semanticscholar   +1 more source

Research Progress of Plant Active Ingredients in Pharmaceutical Cocrystal.

Current Drug Delivery, 2022
The disadvantages of active ingredients extracted from medicinal plants due to poor solubility in the body and low bioavailability limits their clinical application. Pharmaceutical cocrystal as a new type of drug in solid form has attracted the attention
Zimeng Wang, H. Shang, Linghuan Gao, Ning Qiao   +3 more
semanticscholar   +1 more source

Pharmaceutical cocrystal consisting of ascorbic acid with p-aminobenzoic acid and paracetamol

Physical Sciences Reviews, 2022
As small molecule drugs become harder to develop and less cost effective for patient use, efficient strategies for their property improvement become increasingly important for global health initiatives.
F. Miles, F. Djellouli, Nourelhouda Bensiradj, A. Dahmani   +3 more
semanticscholar   +1 more source

Pharmaceutical Cocrystal of Ethenzamide with Gallic Acid: Structural Investigation Based on Terahertz Spectroscopy and DFT Calculation

International Conference on Infrared, Millimeter, and Terahertz Waves, 2022
The pharmaceutical cocrystal of ethenzamide (ETZ) with gallic acid (GA) was synthesized by the solvent evaporation method. Terahertz (THz) spectroscopy and density functional theory (DFT) were used to explore cocrystal molecular structures and ...
Jiale Zhang, Mei Wan, Jiyuan Fang, Zhi Hong, Yong Du   +4 more
semanticscholar   +1 more source

Pharmaceutical cocrystals: An overview

International Journal of Pharmaceutics, 2011
Pharmaceutical cocrystals are emerging as a new class of solid drugs with improved physicochemical properties, which has attracted increased interests from both industrial and academic researchers. In this paper a brief and systematic overview of pharmaceutical cocrystals is provided, with particular focus on cocrystal design strategies, formation ...
Ning, Qiao, Mingzhong, Li, Walkiria, Schlindwein, Nazneen, Malek, Angela, Davies, Gary, Trappitt   +5 more
openaire   +2 more sources

Nanoconfinement of a Pharmaceutical Cocrystal with Praziquantel in Mesoporous Silica: The Influence of the Solid Form on Dissolution Enhancement.

Molecular Pharmaceutics, 2021
Nanoconfinement is a recent strategy to enhance solubility and dissolution of active pharmaceutical ingredients (APIs) with poor biopharmaceutical properties. In this work, we combine the advantage of cocrystals of racemic praziquantel (PZQ) containing a
Reynaldo Salas-Zúñiga, K. Mondragón-Vásquez, Sergio Alcalá-Alcalá, Enrique Lima, H. Höpfl, Dea Herrera-Ruiz, Hugo Morales‐Rojas   +6 more
semanticscholar   +1 more source

Pharmaceutical cocrystals: walking the talk

Chemical Communications, 2016
From Saridon to Entresto: the journey of pharmaceuticals from the first drug–drug combination of propyphenazone and pyrithyldione in 1937 (left) to the most recent monosodium sacubitril and disodium valsartan in 2015 (right).
Geetha, Bolla, Ashwini, Nangia
openaire   +2 more sources

Pharmaceutical Cocrystal: An Antique and Multifaceted Approach.

Current Drug Delivery, 2017
Pharmaceutical cocrystal is an emerging approach to tailor physicochemical and mechanical properties of drug substances. Cocrystals are composed of API and pharmaceutically acceptable coformer. It is used to address the solubility, dissolution, mechanical properties and stability of drugs.This review discusses introduction to cocrystal, preparation ...
P. Panzade, G. Shendarkar
semanticscholar   +3 more sources