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Role of Lattice Disorder in Water-Mediated Dissociation of Pharmaceutical Cocrystal Systems.
Molecular Pharmaceutics, 2019Our objective is to mechanistically understand the implications of processing-induced lattice disorder on the stability of pharmaceutical cocrystals. Caffeine-oxalic acid (CAFOXA) and dicalcium phosphate anhydrate (DCPA) were the model cocrystal (drug ...
Navpreet Kaur +3 more
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Challenges in Translational Development of Pharmaceutical Cocrystals
Journal of Pharmaceutical Sciences, 2017The last 2 decades have witnessed increased research in the area of cocrystals resulting in deeper scientific understanding, increase in intellectual property landscape, and evolution in the regulatory environment. Pharmaceutical cocrystals have received significant attention as a new solid form on account of their ability to modulate poor ...
Dnyaneshwar P, Kale +2 more
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European journal of pharmaceutics and biopharmaceutics, 2018
Graphical abstract Figure. No caption available. ABSTRACT Solid‐state synthesis of pharmaceutical cocrystals is of contemporary interest as it offers an efficient way to modify the physicochemical properties of Active Pharmaceutical Ingredient (API ...
M. Gajda +3 more
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Graphical abstract Figure. No caption available. ABSTRACT Solid‐state synthesis of pharmaceutical cocrystals is of contemporary interest as it offers an efficient way to modify the physicochemical properties of Active Pharmaceutical Ingredient (API ...
M. Gajda +3 more
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NOVEL PHARMACEUTICAL COCRYSTAL OF TELMISARTAN AND HYDROCHLOROTHIAZIDE
Asian Journal of Pharmaceutical and Clinical Research, 2020Objective: Telmisartan (TEL), commonly used antihypertensive, is poorly soluble in water and has limited and variable bioavailability. Commercially, TEL is available as a single drug and in combination with hydrochlorothiazide (HYZ).
Alpana Kulkarni +3 more
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The role of cocrystals in pharmaceutical science
Drug Discovery Today, 2008Pharmaceutical cocrystals, a subset of a long known but little-studied class of compounds, represent an emerging class of crystal forms in the context of pharmaceutical science. They are attractive to pharmaceutical scientists because they can significantly diversify the number of crystal forms that exist for a particular active pharmaceutical ...
Ning, Shan, Michael J, Zaworotko
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Crystal Growth & Design, 2019
In this work, three new cocrystals of the nonsteroidal anti-inflammatory drug flurbiprofen with salicylamide, benzamide, and picolinamide have been discovered using thermodynamic analysis of solid–liquid binary phase diagrams, and their crystal ...
A. Surov +5 more
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In this work, three new cocrystals of the nonsteroidal anti-inflammatory drug flurbiprofen with salicylamide, benzamide, and picolinamide have been discovered using thermodynamic analysis of solid–liquid binary phase diagrams, and their crystal ...
A. Surov +5 more
semanticscholar +1 more source
International Journal of Pharmaceutics, 2012
Cocrystals (CCs) used in the pharmaceutical industry are defined as complex crystals formed by reaction between an API and a cocrystal former (CCF); unlike salts, CCs do not show proton transfer. Recently, pharmaceutical CCs have been used to improve the drug-likeness of APIs, such as solubility and stability.
Katsuhiko, Yamamoto +2 more
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Cocrystals (CCs) used in the pharmaceutical industry are defined as complex crystals formed by reaction between an API and a cocrystal former (CCF); unlike salts, CCs do not show proton transfer. Recently, pharmaceutical CCs have been used to improve the drug-likeness of APIs, such as solubility and stability.
Katsuhiko, Yamamoto +2 more
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Cocrystal Systems of Pharmaceutical Interest: 2009
2011As scientists become more aware of a substantial expansion in the scope of solid-state structural variations that can be obtained through the cocrystallization of several molecules in a single lattice structure, studies of the mixed molecular crystal systems known as cocrystals have mushroomed. Along these lines, workers have researched the assembly of
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Mass transport of pharmaceutical cocrystals
2018<p>Cocrystals have two or more neutral components (drug and cocrystal former) in the same crystal lattice which are held together via non-covalent bonds. Since the presence of the cocrystal former alters the energy of the drug molecules and their physicochemical properties, the drug dissolution characteristics can be manipulated by ...
Hui Zu +6 more
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Pharmaceutical Cocrystals: Molecules, Crystals, Formulations, Medicines
Crystal Growth & Design, 2019Cocrystals are long known yet recently applied molecular entities. In the past decade, a significant potential has been demonstrated by these novel solids in terms of modifying the physicochemical ...
Malaz A. E. Yousef, Venu R. Vangala
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