Results 121 to 130 of about 537,841 (319)

Engineering Novel DNA Nanoarchitectures for Targeted Drug Delivery and Aptamer Mediated Apoptosis in Cancer Therapeutics

open access: yesAdvanced Functional Materials, EarlyView.
Designer DNA Architecture‐templated Drug Conjugates (DDA‐DCs) are comprised of a DNA nanomaterial decorated with multiple drug‐loaded DNA aptamers. DDA‐DCs use a combination of multiple aptamer types, each recognizing a different membrane protein to achieve precise targeting of cancer cells.
Abhisek Dwivedy   +19 more
wiley   +1 more source

Indian Pharma Within Global Reach? [PDF]

open access: yes
The Indian pharmaceutical industry is presently going through a phase of transition and potential consolidation, owing to India's new TRIPS-compliant intellectual property regime and other rules aimed at enhancing the industry's credibility nationally ...
Gehl Sampath, Padmashree
core  

Drivers of organizational creativity [PDF]

open access: yes, 2005
A path model of organizational creativity was presented; it conceptualized the influences of information sharing, learning culture, motivation, and networking on creative climate.
Dimenäs, Elof   +3 more
core  

Enhancement of doxorubicin production in Streptomyces peucetius by genetic engineering and process optimization

open access: yesAMB Express
Doxorubicin is an important class of anthracycline antitumor antibiotics produced by Streptomyces peucetius. The doxorubicin fermentation yield of the wild-type strain was very low, so it could not be produced directly by fermentation at an industrial ...
Songbai Yang   +4 more
doaj   +1 more source

From RAG to QA-RAG: Integrating Generative AI for Pharmaceutical Regulatory Compliance Process [PDF]

open access: yesarXiv
Regulatory compliance in the pharmaceutical industry entails navigating through complex and voluminous guidelines, often requiring significant human resources. To address these challenges, our study introduces a chatbot model that utilizes generative AI and the Retrieval Augmented Generation (RAG) method.
arxiv  

Intraoral Drug Delivery: Bridging the Gap Between Academic Research and Industrial Innovations

open access: yesAdvanced Functional Materials, EarlyView.
Intraoral drug delivery offers a promising route for systemic and localized therapies, yet challenges such as enzymatic degradation, limited permeability, and microbial interactions hinder efficacy. This figure highlights innovative strategies—mucoadhesive materials, enzyme inhibitors, and permeation enhancers—to overcome these barriers.
Soheil Haddadzadegan   +4 more
wiley   +1 more source

Breakthrough Solution for Antimicrobial Resistance Detection: Surface‐Enhanced Raman Spectroscopy‐based on Artificial Intelligence

open access: yesAdvanced Materials Interfaces, EarlyView., 2023
This review discusses the use of Surface‐Enhanced Raman Spectroscopy (SERS) combined with Artificial Intelligence (AI) for detecting antimicrobial resistance (AMR). Various SERS studies used with AI techniques, including machine learning and deep learning, are analyzed for their advantages and limitations.
Zakarya Al‐Shaebi   +4 more
wiley   +1 more source

Reconciling social and industrial goals: a bargaining model to pricing pharmaceuticals [PDF]

open access: yes
The issues at stake for determining the price of a drug are related to finding an "equitable" trade-off between the legitimate need for the pharmaceutical industry to make a profit and full exploitation of the consumer’s surplus in a market with ...
Rosella Levaggi, Stefano Capri
core  

A cleanroom contamination control system [PDF]

open access: yes, 2002
Analytical methods for hazard and risk analysis are being considered for controlling contamination in pharmaceutical cleanrooms. The most suitable method appears to be the HACCP system that has been developed for the food industry, but this requires ...
Eaton, T., Whyte, W.
core  

Design of a novel long-acting insulin analogs by acetylation modification and compared with insulin Icodec

open access: yesScientific Reports
Insulin is a potent medication for managing diabetes, yet its short half-life requires daily administration. Currently, Novo Nordisk’s icodec is the sole insulin available on the market that requires administration only once a week.
Min Yu   +6 more
doaj   +1 more source

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