Results 91 to 100 of about 3,602,513 (298)

Precision Editing of NLRS Improves Effector Recognition for Enhanced Disease Resistance

Advanced Science, EarlyView.
Precision engineering of plant NLR immune receptors enables rational design of enhanced pathogen resistance through mismatched pairing, domain swapping, and targeted mutagenesis. These approaches achieve multi‐fold expansion in recognition breadth while minimizing autoimmunity risks and fitness penalties.
Vinit Kumar, Vishwa I. P. W. A. Kumara, Pradeepa C. G. Bandaranayake, Dong Yawen, Yang‐Yang Gao, Junfeng Liu, Ge‐Fei Hao, Xiu‐Fang Xin   +7 more
wiley   +1 more source

Navigating the Ethereal Tightrope: The Nanogenerator Manipulates Neurons for Immune Equilibrium

Advanced Science, EarlyView.
This review explores how nanogenerators modulate neuroimmune responses, offering innovative strategies for treating neurological disorders. By interfacing with neural pathways, they enable precise control of immune activity, especially via vagus nerve stimulation.
Jia Du, Rui Deng, Ya Wu, Hong‐Xia Ren, Zong‐Hong Lin, Yang‐Bao Miao   +5 more
wiley   +1 more source

Common Ownership and Market Entry: Evidence from Pharmaceutical Industry

American Economic Journal: Microeconomics, 2018
Common ownership—where several firms are (partially) owned by the same investors—and its impact on product market competition has recently drawn much attention. This paper focuses on its implications for market entry.
Melissa Newham, J. Seldeslachts, Albert Banal‐Estañol   +2 more
semanticscholar   +1 more source

Structure‐Based Development of Ultra‐Broad‐Spectrum 3C‐Like Protease Inhibitors

Advanced Science, EarlyView.
This study provides an in‐depth analysis of the substrate binding pocket of 3CLpros across all coronavirus species using bioinformatics and structural insights, revealing the critical impact of S2/S4 subsite diversity on the broad‐spectrum activity of approved therapeutics.
Haixia Su, Tianqing Nie, Guofeng Chen, Muya Xiong, Yumin Zhang, Guoqing Wu, Mengyuan You, Hang Xie, Jian He, Yanchao Xiong, Hangchen Hu, Wenfeng Zhao, Minjun Li, Gengfu Xiao, Leike Zhang, Yechun Xu   +15 more
wiley   +1 more source

PHARMACEUTICAL MARKETING: OBJECTIVES AND TYPES

Scientific Messenger of LNU of Veterinary Medicine and Biotechnologies, 2016
Pharmaceutical marketing objectives and types depending on demand state are overviewed in this article. Pharmaceutical enterprise has always a certain idea of the desired level of market demand. In practice demand is not always in accordance with level that has been predicted.
SMOLYNETS’ I.B., GUTYJ B.V., KHARIV І.І., PETRYSHAK O.Y., LYTVYN R.I.   +4 more
openaire   +2 more sources

METTL5 Enables Immune Evasion of Liver Cancer via Chemokine mRNA Translation Regulation

Advanced Science, EarlyView.
METTL5 reshapes the tumor immune microenvironment through ribosome 18S rRNA m6A modification to regulate the translation of chemokine mRNA. Targeting METTL5‐mediated immunosuppression unleashes anti‐tumor immunity and improves the efficacy of anti‐PD‐1 therapy.
Shuang Li, Xiao Zhao, Tongtong Song, Qiaoyi Chen, Yanqing Wu, Yuting Zhang, Jingying Chen, Yifan Wu, Bin Li, Xinyue Zhang, Zihao Dai, Lixia Xu, Yubin Xie, Alfred Sze‐Lok Cheng, Jianping Guo, Ming Kuang, Shuibin Lin, Zhenwei Peng, Sui Peng, Xuezhen Zeng   +19 more
wiley   +1 more source

Pricing strategy research in the dual-channel pharmaceutical supply chain considering service

Frontiers in Public Health
In the context of developing a new era, the pharmaceutical supply chain market has gradually transformed from a seller’s market to a buyer’s market. The closer the consumers are, the greater the market pricing power, so the pharmaceutical market power of
Qian Lu, Qian Lu, Qian Lu, Qing Liu, Qing Liu, Yong Wang, Yong Wang, Mingke Guan, Mingke Guan, Zhigang Zhou, Yajun Wu, Jiamin Zhang   +11 more
doaj   +1 more source

Quantitative Proteomics and CRISPR/Cas9 Editing Reveal UPR‐Mediated Control of Immunoglobulin Homeostasis in Hybridomas

Advanced Science, EarlyView.
BCR sequencing and subclone analysis correlated immunoglobulin (Ig) chain loss in dysfunctional hybridomas with disrupted monoclonal antibody homeostasis. Proteomics‐guided CRISPR/Cas9 editing revealed that the unfolded protein response (UPR) regulates aberrant Ig synthesis.
Rubing Zou, Xinying Lu, Ying Liu, Peiyu Yang, Shuo Sun, Yihua Liu, Yinyuan Mo, Guonian Zhu, Jae Seong Lee, Yirong Guo   +9 more
wiley   +1 more source

Analysis of Russian pharmaceutical specialists labor market for 2019–2022

Фармация и фармакология (Пятигорск)
The higher education system is becoming more and more competitive every year. It faces ambitious tasks of training highly qualified personnel and ensuring technological sovereignty.
D. V. Kurkin, Yu. S. Knyazeva, O. V. Ivanova, Yu. A. Kolosov, Yu. V. Gorbunova, D. A. Bakulin, I. S. Krysanov, D. L. Klabukova, M. A. Javakhyan, V. I. Zvereva, N. A. Lycheva, V. N. Shoich, V. V. Neyolova, E. V. Pavlova, E. I. Morkovin, E. A. Kalashnikova, A. B. Bosenko, D. Z. Zyazikova, R. E. Musaev, A. G. Gadzhiev, B. M. Gabrielyan, A. A. Agamirova, V. I. Petrov   +22 more
doaj   +1 more source

Who initiates price competition when generic entrants are introduced into the South Korean pharmaceutical market? [PDF]

Front Public Health, 2022
Son KB.
europepmc   +1 more source