Results 81 to 90 of about 111,213 (213)
Socio-economic significance and characteristic features of pharmacy [PDF]
Problemi Ekonomiki, 2013 The article considers main factors indicative of significance of the world pharmaceutical industry in the global economy. It shows the total volume of the world pharmaceutical market and regional structure of the world pharmaceutical production. It marks
Tischenko Aleksandr N. +1 more
doaj
Perceived impact of the patent linkage system on pharmaceutical market from the viewpoint of the domestic manufacturers in South Korea. [PDF]
Global Health, 2022 Choi N, Son KB, Byun J, Yang DW.
europepmc +1 more source
When Biology Meets Medicine: A Perspective on Foundation Models
Advanced Intelligent Discovery, EarlyView.Artificial intelligence, and foundation models in particular, are transforming life sciences and medicine. This perspective reviews biological and medical foundation models across scales, highlighting key challenges in data availability, model evaluation, and architectural design.
Kunying Niu +3 more
wiley +1 more source
Angewandte Chemie, EarlyView.A new class of “super‐strained” spiro heterocycles—spirocyclic 1‐azabicyclo[1.1.0]butanes—was synthesized via insertion of cyclobutane‐, oxetane‐, and azetidine‐containing sulfonium reagents into substituted azirines. The stability of this new class of compounds was studied.
Philipp Natho +9 more
wiley +2 more sources
Frontiers in Public HealthPrevious studies have extensively explored industrial innovation, but the impact of downstream buyer market power on upstream industries remains underexamined.
Yu Guanyi +3 more
doaj +1 more source
Changes in pharmaceutical market and "fake drug" problem in the Qing period. [PDF]
Uisahak, 2021 Choi J.
europepmc +1 more source
Advanced Intelligent Discovery, EarlyView.A machine learning framework simultaneously predicts four critical properties of monomers for emulsion polymerization: propagation rate constant, reactivity ratios, glass transition temperature, and water solubility. These tools can be used to systematically identify viable bio‐based monomer pairs as replacements for conventional formulations, with ...
Kiarash Farajzadehahary +1 more
wiley +1 more source
Pyridine C─N Transposition via Cycloaddition–Cycloreversion
Angewandte Chemie, EarlyView.Transposition of pyridine nitrogen from the 4‐ to the 3‐position is described using two open and shut sequences: a nucleophile addition ring‐open ring‐closure, followed by a nitrile Diels–Alder cycloaddition cycloreversion. The nitrogen swap is particularly effective for tertiary alkyl substituents, transforming easily accessible para‐alkylated ...
Aífe Conboy, Michael F. Greaney
wiley +2 more sources
Large‐Scale Machine Learning to Screen for Small‐Molecule Senolytics
Advanced Intelligent Discovery, EarlyView.A consistent workflow underpins all experiments in this study. A dedicated model‐selection dataset first identifies optimal hyperparameters for each algorithm. Models are then trained and rigorously evaluated on independent sets of molecules using the senolytic ratio SR. Comprehensive hyperparameter exploration across SMILES representations, task types,
Alexis Dougha +2 more
wiley +1 more source
Angewandte Chemie, EarlyView.Using a ketal‐protected glycerol derivative (solketal) as the oxidation substrate enables site‐selective electrooxidation that suppresses C–C cleavage on non‐noble catalysts. Highly alkaline conditions promote reactive solketal alkoxide formation, weaken the Cα─H bond to facilitate dehydrogenation, and buffer local acidification, enabling a record‐high
Jiamin Wang +6 more
wiley +2 more sources