Results 91 to 100 of about 1,067,890 (357)

Rethinking plastic waste: innovations in enzymatic breakdown of oil‐based polyesters and bioplastics

open access: yesFEBS Open Bio, EarlyView.
Plastic pollution remains a critical environmental challenge, and current mechanical and chemical recycling methods are insufficient to achieve a fully circular economy. This review highlights recent breakthroughs in the enzymatic depolymerization of both oil‐derived polyesters and bioplastics, including high‐throughput protein engineering, de novo ...
Elena Rosini   +2 more
wiley   +1 more source

Application of hydrophilic interaction liquid chromatography for the quantification of succinylcholine in Active Pharmaceutical Ingredient and medicinal product. Identification of new impurities of succinylcholine chloride

open access: yesHeliyon, 2018
A new method, using hydrophilic interaction chromatography (HILIC), for quantification of succinylcholine and impurities in Active Pharmaceutical Ingredient (API), as well as in the medicinal product, was developed.
Arkadiusz Szterk   +2 more
doaj   +1 more source

Data Science in Pharmaceutical Industry

open access: yes, 2020
Data Science demand from Medical Affairs (MA) functions in the pharmaceutical industry are exponentially increasing, where business cases around more modern execution of activities and strategic planning are becoming a reality. MA is still lagging in terms of implementing data science and big data technology in the current times, which means a ...
Pesqueira, A.   +3 more
openaire   +2 more sources

Geographic proximity and firm-university innovation linkages: evidence from Great Britain [PDF]

open access: yes
We investigate evidence for spatially mediated knowledge transfer from university research. We examine whether firms locate their R&D labs near universities, and whether those that do are more likely to co-operate with, or source knowledge from ...
Helen Simpson, Laura Abramovsky
core  

Reimagining Your Rx [PDF]

open access: yes, 2016
Your future prescriptions might be manufactured in a portable factory – or even be produced by your body itself. Dr. Thomas Roper, director of pharmaceutical engineering in VCU’s Department of Chemical & Life Science Engineering, says the goal is to ...
Jones, Rebecca
core   +1 more source

Trust, regulatory processes and NICE decision-making: Appraising cost-effectiveness models through appraising people and systems. [PDF]

open access: yes, 2015
This article presents an ethnographic study of regulatory decision-making regarding the cost-effectiveness of expensive medicines at the National Institute for Health and Care Excellence (NICE) in England.
Abraham J   +18 more
core   +1 more source

Lactoferrin treatment activates acetylcholinesterase, decreasing acetylcholine levels in non‐small cell lung cancer (NSCLC) cell culture supernatants, inhibiting cell survival

open access: yesFEBS Open Bio, EarlyView.
Representation of the suggested mode of action of lactoferrin (Lf) in nonsmall cell lung cancer (NSCLC) A549 cells. Lf induces activation of caspase‐3 by activating p53 and AChE leading to decreased ACh concentrations. In turn, ACh signaling leads to activation of VEGF and AKT and blocking of caspase‐3.
Stuti Goel   +9 more
wiley   +1 more source

Proportionality between powder cohesion and unconfined yield strength from shear cell testing

open access: yesHeliyon, 2019
From an analysis of the geometry of the yield locus and the Mohr's circle for determining unconfined yield strength (fc) in shear cell testing, it has been shown that powder cohesion is proportional to fc, where the proportionality constant is a function
David J. Sun, Changquan Calvin Sun
doaj   +1 more source

Overexpression of CDT1 inhibits cell cycle progression at S phase by interacting with the mini‐chromosome maintenance complex and causes DNA damage

open access: yesFEBS Open Bio, EarlyView.
CDT1 is an essential protein for DNA replication licensing that loads the MCM complex, the eukaryotic replicative DNA helicase, onto replication origins. Overexpression of CDT1 induces cell cycle arrest at the S phase. Here we showed CDT1 inhibits the progression of replication forks by interacting with the MCM complex, leading to the stalling and ...
Takashi Tsuyama   +7 more
wiley   +1 more source

Early Academis Science and the Birth of Industrial Research Laboratories in the U.S. Pharmaceutical Industry [PDF]

open access: yes
The establishment and growth of industrial research laboratories is one of the key organizational innovations affecting technological progress in the United States in the 20th century.
Jeffrey L. Furman, Megan MacGarvie
core  

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