Results 91 to 100 of about 5,230,993 (373)

Beyond digital twins: the role of foundation models in enhancing the interpretability of multiomics modalities in precision medicine

FEBS Open Bio, EarlyView.
This review highlights how foundation models enhance predictive healthcare by integrating advanced digital twin modeling with multiomics and biomedical data. This approach supports disease management, risk assessment, and personalized medicine, with the goal of optimizing health outcomes through adaptive, interpretable digital simulations, accessible ...
Sakhaa Alsaedi, Xin Gao, Takashi Gojobori   +2 more
wiley   +1 more source

Data Science in Pharmaceutical Industry

, 2020
Data Science demand from Medical Affairs (MA) functions in the pharmaceutical industry are exponentially increasing, where business cases around more modern execution of activities and strategic planning are becoming a reality. MA is still lagging in terms of implementing data science and big data technology in the current times, which means a ...
Pesqueira, A., Sousa, M. J., Rocha, Á., Sousa, M.   +3 more
openaire   +3 more sources

Knockout of the mitoribosome rescue factors Ict1 or Mtrfr is viable in zebrafish but not mice: compensatory mechanisms underlying each factor's loss

FEBS Open Bio, EarlyView.
Mitochondria contain two mitoribosome rescue factors, ICT1 and MTRFR (C12orf65). ICT1 also functions as a mitoribosomal protein in mice and humans, and its loss is lethal. Although Mtrfr knockout mice could not be generated, knockout zebrafish lines for ict1 and mtrfr were established.
Nobukazu Nameki, Chika Tomisawa, Soichiro Hoshino, Hidehiko Shimizu, Masashi Abe, Sho Arai, Kanako Kuwasako, Naoki Asakawa, Yusuke Inoue, Takuro Horii, Izuho Hatada, Masakatsu Watanabe   +11 more
wiley   +1 more source

Nine years of comparative effectiveness research education and training: initiative supported by the PhRMA Foundation [PDF]

, 2018
The term comparative effectiveness research (CER) took center stage with passage of the American Recovery and Reinvestment Act (2009). The companion US$1.1 billion in funding prompted the launch of initiatives to train the scientific workforce capable of
Brixner, Diana I, Cannon, Eileen, Devine, Emily Beth, Gagnon, Jean Paul, Garrison, Louis P, Murray, Michael D, Perfetto, Eleanor, Pickard, A Simon, Schumock, Glen T, Segal, Jodi B   +9 more
core   +1 more source

BBMRI-ERIC as a resource for pharmaceutical and life science industries: the development of biobank-based Expert Centres

European Journal of Human Genetics, 2014
Biological resources (cells, tissues, bodily fluids or biomolecules) are considered essential raw material for the advancement of health-related biotechnology, for research and development in life sciences, and for ultimately improving human health ...
G. V. van Ommen, Outi M. Törnwall, C. Bréchot, Georges Dagher, Joakim Galli, K. Hveem, U. Landegren, C. Luchinat, A. Metspalu, C. Nilsson, O. Solesvik, M. Perola, Jan-Eric Litton, K. Zatloukal   +13 more
semanticscholar   +1 more source

Profiling the effect of low frequency mechanical vibration on the metabolic and oxidative stress responses of A431 carcinoma

FEBS Open Bio, EarlyView.
20 Hz mechanical vibration induced A431 cancer cells' apoptosis without such effect on other healthy cell lines of L929 and C2C12. Lowered glucose consumption is observed specifically in A431. The expressions of ROS, HMGB1, and HSP1 levels initially increase and subsequently decrease in the cancer cell line, as opposed to L929 and C2C12, which ...
Wresti L. Anggayasti, Chikahiro Imashiro, Takashi Morikura, Shogo Miyata, Akira Funahashi, Kenjiro Takemura   +5 more
wiley   +1 more source

Young donor white blood cell immunotherapy induces extensive tumor necrosis in advanced-stage solid tumors

Heliyon, 2017
Background: In the past decade, a variety of immunotherapy approaches focused predominantly on the adaptive immune system have shown unprecedented responses in patients with advanced-stage malignancies. However, studies in spontaneous regression/complete
Dipnarine Maharaj, Pedro G. Vianna, Wendy Ward, Anthony J. Messina, Trevor Rayborn, Jacqueline V. Gouvea, Richard D. Hammer, Zheng Cui   +7 more
doaj  

Opioid agonist treatment for pharmaceutical opioid dependent people.

Cochrane Database of Systematic Reviews, 2016
BACKGROUND There are increasing concerns regarding pharmaceutical opioid harms including overdose and dependence, with an associated increase in treatment demand.
S. Nielsen, B. Larance, L. Degenhardt, L. Gowing, Chyanne Kehler, N. Lintzeris   +5 more
semanticscholar   +1 more source

Phenotypic plasticity in a novel set of EGFR tyrosine kinase inhibitor‐adapted non‐small cell lung cancer cell lines

FEBS Open Bio, EarlyView.
Phenotypic plasticity in a newly established set of EGFR inhibitor‐adapted NSCLC cell lines during adaptation and in established cell lines. Here, we introduce novel sublines of the EGFR‐mutant non‐small cell lung cancer (NSCLC) cell lines HCC827 and HCC4006 adapted to the EGFR kinase inhibitors gefitinib (HCC827rGEFI2μm, HCC4006rGEFI1μm), erlotinib ...
Tharsagini V. Nanthaprakash, Campbell W. Gourlay, Ina Oehme, Michelle D. Garrett, Jindrich Cinatl Jr, Mark N. Wass, Martin Michaelis   +6 more
wiley   +1 more source

Medical Devices: European Union Policymaking and the Implementation of Health and Patient Safety in France: book review [PDF]

, 2012
by Christa Altenstetter Piscataway, NJ: Transaction Publishers, 2007, 302 pp., $ 49.95, Hardcover This book is a welcome addition to the political science literature on medical product policymaking.
Chowdhury, N.
core   +2 more sources