Results 91 to 100 of about 25,044 (295)

Androgen Receptor‐Induced Lactoferrin Accelerates Prostate Tumorigenesis Through Modulating Ferroptosis

Advanced Science, EarlyView.
This study demonstrates that transcription factor androgen receptor (AR) directly binds the LF promoter, driving lactoferrin overexpression to promote ferritin (FTH1/FTL) upregulation and inhibit p53‐ALOX12‐mediated ferroptosis in prostate cancer. Lactoferrin could be a new potential therapeutic target in prostate cancer.
Can Liu, Qiu Peng, Xiaoyue Zhang, Zhengshuo Li, Yangge Wu, Yuqing Wen, Run Zheng, Shuanglong Wu, Chenfei Zhou, Zhengyu Hu, Lanjun Shu, Xinyi Ma, Qiuyang Li, Ya Ma, Chunlin Ou, Ming Zhao, Songqing Fan, Lingyu Wei, Jian Ma   +18 more
wiley   +1 more source

Preparation and Evaluation of Microemulsion Formulations of Naproxen for Dermal Delivery

, 2014
Naproxen (Np) is an example of a non-steroidal anti-inflammatory drug (NSAID) commonly used for the reduction of pain and inflammation. In order to develop an alternative formulation for the topical administration of Np, microemulsions were evaluated as ...
Okur, Neslihan Ustundag, Yavasoglu, Altug, Karasulu, Hatice Yesim   +2 more
core  

Quality by Design Considerations for Drop-on-Demand Point-of-Care Pharmaceutical Manufacturing of Precision Medicine

Distributed and point-of-care (POC) manufacturing facilities enable an agile pharmaceutical production paradigm that can respond to localized needs, providing personalized and precision medicine.
William , Feeney, Johnny, Ho, John Greg, Gillen, Thomas P, Forbes   +3 more
core   +1 more source

Examination and evaluation of pharmaceutical designed and made patent applications for gene therapy

, 2016
In recent years, one the most popular subjects of drug biotechnology is gene therapy products. When Human Genome Project was accomplished, accessing to desired genes became so much easier and this data brought a new perspective to various diseases; such ...
SEZER, ALİ DEMİR
core   +1 more source

Effects of formulation on pharmacokinetics of docetaxel in rats

, 2020
The aim of this study was to investigate the effects of formulation vehicles on the pharmacokinetics of docetaxel. The following three formulations of docetaxel were prepared to compare the pharmacokinetic profiles of docetaxel: Tween® 80 formulation (a ...
이화정, 이병구
core   +1 more source

FGF13 Deficiency Ameliorates Paclitaxel‐Induced Neuropathic Pain by Inhibiting VASH1‐Mediated Microtubule Detyrosination to Promote Mitophagy

Advanced Science, EarlyView.
FGF13 is upregulated in DRG neurons of PIPNP model mice. DRG neuron‐specific knockout of FGF13 ameliorates PIPNP symptoms. Mechanistically, FGF13 potentiates microtubule detyrosination by promoting VASH1 binding to microtubules. FGF13 knockout suppresses VASH1‐mediated microtubule detyrosination and promotes α‐tubulin tyrosination.
Yiming Dong, Yidan Wang, Simeng Lv, Zishan Dong, Kaixi Zhi, Xiuhua Guo, Xuyan Li, Ruoxi Yu, Yiyi Zhang, Siyuan Cheng, Chuan Wang   +10 more
wiley   +1 more source

Next-generation green marine pharmaceutical excipients: integrating multifunctionality and precision drug delivery

Green Chemistry Letters and Reviews
The pharmaceutical manufacturing industry stands at a critical point, and it must address environmental limitations, while medical researchers develop new medical treatments.
Ahmed I. Foudah, Akil Ahmad, Aftab Alam
doaj   +1 more source

A Bioinspired Three‐Dimensional High‐Curvature Nano‐Interface Integrated Microfluidic Chip for Small Extracellular Vesicles Enrichment and Machine Learning‐Assisted Prostate Cancer Precision Diagnosis

Advanced Science, EarlyView.
A biotin‐modified artificial insertion peptide functionalized three‐dimensional high‐curvature‐TiO2 nano‐interface was engineered in a microfluidic chip to improve the isolation efficiency of small extracellular vesicles (sEVs). This chip balanced affinity, releasability, and extendibility, enabling high‐throughput recovery of sEVs for downstream ...
Le Wang, Yizhong Liang, Manan Sulaiman, Jiaqi Du, Ming Jiang, Zhihua Wang, Xu Yu, Li Xu   +7 more
wiley   +1 more source

Cuproptosis and Mitophagy Mediated by the THUMPD1/IGF2R‐Dependent Suppression of AKT and Activation of AMPK Signaling Suppress Lung Adenocarcinoma Progression

Advanced Science, EarlyView.
THUMPD1 drives a tumor‐suppressive signaling cascade in lung adenocarcinoma by promoting IGF2R expression. IGF2R associates with PPP2R1A to suppress AKT and activate AMPK, leading to SLC31A1 upregulation and copper accumulation. Elevated copper disrupts mitochondrial metabolism and induces excessive mitophagy, thereby restraining tumor growth and ...
Kai Wu, Bo Qin, Zhuoyu Gu, Weizheng Ding, Xiaoming Chen, Kaishang Zhang, Yujin Qiao, Shuang Yuan, Song Zhao, Xiangnan Li, Peng Zhang   +10 more
wiley   +1 more source

Current Perspectives in Nanotechnology and Nanomedicine [PDF]

Perspectives In Medical Research, 2019
The idea of nanoparticles, nanotechnology, and their applications to medicine could have emerged from the increase in the incidences of malignancies, due to the paucity of safe and effective anti-cancer drugs, and lack of sensitive diagnostic tools ...
Sabitha Vadakedath1 , Sanagapally Revanth Venkatsai Shanmukh2 , Srujani Karra3 , Venkataramana Kandi4 *
doaj