Results 71 to 80 of about 25,044 (295)

The Utility of Lipids as Nanocarriers and Suitable Vehicle in Pharmaceutical Drug Delivery

open access: yesCurrent Nanomaterials, 2019
Lipid based excipients have gained popularity recently in the formulation of drugs in order to improve their pharmacokinetic profiles. For drugs belonging to the Biopharmaceutics Classification System (BCS) class II and IV, lipid excipients play vital roles in improving their pharmacokinetics properties.
Salome A. Chime   +2 more
openaire   +1 more source

Managing Disposal of Unwanted Pharmaceuticals at Health Facilities in Tanzania: A case of Dar es salaam Region Public Health Facilities [PDF]

open access: yes, 2011
In the public sector medicines are the property of the state, for which strict accounting procedures to write-off the unwanted pharmaceutical stock are necessary (Public Finance Act & Regulations, 2004).
Matiko, Damas
core  

Adipocyte‐Derived Leptolin Enhances Energy Expenditure and Prevents Obesity

open access: yesAdvanced Science, EarlyView.
We identified a novel adipokine, which we named leptolin. In humans, leptolin levels in white adipose tissue were positively correlated with exercise and negatively associated with body mass index. We observed elevated leptolin in serum from athletes and lower leptolin in serum from obese individuals.
Jiarui Liu   +17 more
wiley   +1 more source

Unveiling the promise: Exosomes as game‐changers in anti‐infective therapy

open access: yesExploration
Extracellular vesicles (EVs)‐based intercellular communication (through exosomes, microvesicles, and apoptotic bodies) is conserved across all kingdoms of life.
Vivek P. Chavda   +9 more
doaj   +1 more source

In vitro release of dibucaine hydrochloride from chitosan semisolid vehicles: emulsion and hydrophilic gels [PDF]

open access: yesJournal of Pharmacy & Pharmacognosy Research, 2017
Context: Chitosan has received attention as a functional, sustainably renewable, nontoxic and biodegradable biopolymer for pharmaceutical applications.
Nilia de la Paz   +6 more
doaj  

Formulation and Evaluation of Quality Parameters of Effervescent Granules from the Potent Antioxidant between Two Variants of the Adaptogenic Herb Ocimum tenuiflorum L.

open access: yesThe Scientific World Journal, 2023
Ocimum tenuiflorum L. is found throughout semitropical and tropical parts of Southeast Asia. In Nepal, O. tenuiflorum L. is popular with two variants: Krishna Tulsi consisting of purple-colored leaves and Sri Tulsi consisting of green-colored leaves.
Kalpana Parajuli-Baral
doaj   +1 more source

Targeting Peptostreptococcus anaerobius with an Iron‐Based Nanozyme Reverses Ferroptosis Resistance and Enhances Antitumor Immunity in Colorectal Cancer

open access: yesAdvanced Science, EarlyView.
An iron‐based nanozyme selectively eliminates intratumoral P. anaerobius while catalytically generating ROS to induce ferroptosis, synergistically suppressing colorectal cancer growth and activating anti‐tumor immunity through immunogenic cell death. ABSTRACT The intratumoral microbiota is a critical determinant of therapeutic outcomes in colorectal ...
Yinghao Cao   +11 more
wiley   +1 more source

Multiobjective optimization in delivering pharmaceutical products with disrupted vehicle routing problem

open access: yesInternational Journal of Industrial Engineering Computations, 2020
Cet article s'intéresse à la distribution de produits pharmaceutiques qui est l'une des activités les plus importantes et assure la disponibilité des produits pharmaceutiques à un ensemble de clients (pharmacies).L' étude introduit le problème du Disrupted Vehicle Routing avec Soft Time Windows puisque les distributeurs pharmaceutiques devraient ...
Bouziyane Bouchra   +2 more
openaire   +1 more source

Depth or breadth: towards a contingency model of innovation strategy in the automotive sector [PDF]

open access: yes, 2010
The thesis explores the strategic choices made by automotive manufacturers in developing and deploying technology that is discontinuous and potentially disruptive. It studies the deployment of seat belts, airbags, hybrid vehicles and fuel cell electric
Rosenberg, Mike
core  

PRMT1‐Mediated LDHA Methylation Drives STAT3 Lactylation to Orchestrate Intestinal Inflammation and Tumorigenesis

open access: yesAdvanced Science, EarlyView.
This study identifies an immunometabolic axis wherein SAM‐driven PRMT1 methylates LDHA, enhancing its activity. The resultant lactate induces STAT3 K709 lactylation, which stabilizes an active conformation to promote STAT3 phosphorylation and IL‐10 expression.
Hui Wang   +12 more
wiley   +1 more source

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