Results 121 to 130 of about 25,044 (295)
Using computational methods for the prediction of drug vehicles
, 2014 NoDrug vehicles are chemical carriers that aid a drug's passage through an organism. Whilst they possess no intrinsic efficacy they are designed to achieve desirable characteristics which can include improving a drug's permeability and or solubility ...
Anna Palczewska +8 more
core +1 more source
Advanced Science, EarlyView.Dysregulated TCA cycle contributes to Alzheimer's disease (AD) pathogenesis. Here, we show that microglial isocitrate dehydrogenase 1 (IDH1) is a critical driver. Elevated IDH1 disrupts citrate metabolism and mitochondrial function, exacerbating AD pathology.
Qianqian Li +13 more
wiley +1 more source
Advanced Science, EarlyView.A fibroblast activation protein (FAP)‐targeted small molecule–drug conjugate (SMDC) platform is developed to integrate PET imaging with synergistic radionuclide–chemotherapy. Linker chemistry governs stability, exposure, and tolerability, with the VC linker providing superior in vivo performance.
Ruitao Yang +6 more
wiley +1 more source
Secreted Nonstructural Protein 3 is a Pathogenic Determinant of Orbivirus
Advanced Science, EarlyView.This study uncovers a conserved PIP2‐dependent secretory pathway of orbivirus NS3 that induces vascular leakage. Pharmacological disruption of PIP2‐NS3 interaction significantly reduces viral pathogenicity and provides protective efficacy in murine models, establishing PIP2‐mediated NS3 secretion as both a key virulence determinant and a promising ...
Junyong Guan +11 more
wiley +1 more source
Advanced Science, EarlyView.By leveraging this homodimerization mechanism, molecular glues were rationally designed to induce dysfunctional 3A dimerization, thereby restoring antiviral RNAi. The optimal molecular glue, VTP‐32, demonstrated potent and pan‐enterovirus (groups A, B, D) antiviral effects.
Yuan Fang +13 more
wiley +1 more source
Progress and Challenges of Topical Delivery Technologies Meditated Drug Therapy for Osteoarthritis
International Journal of NanomedicineCheng-Yu Shentu,1 Hao-Bin Wang,1 Xiao Peng,2 Dong-Chen Xu,1 Li-Na Qian,1 Yong Chen,1,2 Li-Hua Peng1– 3 1College of Pharmaceutical Sciences, Zhejiang University, Hangzhou, People’s Republic of China; 2Jinhua Institute of Zhejiang University, Jinhua ...
Shentu CY +6 more
doaj
A Multi-Trip Vehicle Routing Problem with Time Windows for Pharmaceutical Distribution [PDF]
This study addresses the multi-trip vehicle routing problem with time windows in the pharmaceutical distribution domain. The objective is to minimize the number of vehicles used to delivery pharmaceutical goods to customers satisfying hard time windows ...
Riccardo Lancellotti +4 more
core
Discovery of a Potent Fluorescence Polarization Probe for Identifying USP1 Allosteric Inhibitors
Advanced Science, EarlyView.This study presents the first ubiquitin‐specific protease 1 (USP1) allosteric fluoroprobe and fluorescence polarization assay, enabling the differentiation of allosteric and catalytic site inhibitors. Further, a novel class of tetrahydroisoquinoline‐based USP1 inhibitors is designed, with compound 14a (USP1 IC50 = 29.9 nM) showing strong selectivity ...
Jiawei Cheng +12 more
wiley +1 more source
Polymeric Nanohydrogel in Topical Drug Delivery System
International Journal of NanomedicineNia Yuniarsih,1,2,* Anis Yohana Chaerunisaa,1,* Khaled M Elamin,3,* Nasrul Wathoni1,* 1Department of Pharmaceutics and Pharmaceutical Technology, Faculty of Pharmacy, Universitas Padjadjaran, Sumedang, 45363, Indonesia; 2Department of ...
Yuniarsih N +3 more
doaj
Advanced Science, EarlyView.The study elucidates that paternal preconception stress can drive offspring hyperresponsivity of the stress system via hypomethylation of a specific DNA region in sperm. This key link is confirmed in a cohort of prospective fathers: the epigenetic alteration is associated with elevated stress hormone levels.
Mengxi Lu +10 more
wiley +1 more source