Results 131 to 140 of about 25,044 (295)

A Hybrid Approach for Outlier Detection in Pharmaceutical Cold Chain Logistics: A Case Study

Pharmaceutical products are highly sensitive to environmental factors including temperature fluctuations, humidity, light and vibrations. Therefore, pharmaceutical cold chain disruptions pose significant human health, financial and regulatory risks, with
Yıldız Özenç, Sevde Ceren, Er, Merve, Oktay Firat, Seniye Umit   +2 more
core   +1 more source

Engineering Oncolytic Virus‐Armed Macrophages for Enhanced Cancer Immunotherapy

Advanced Science, EarlyView.
ZIFOA‐M is engineered by conjugating oncolytic adenovirus‐loaded ZIF‐8 nanoparticles onto macrophage surfaces via bioorthogonal chemistry. Upon tumor infiltration, the platform releases OA to downregulate CD47/CD24 on tumor cells, restoring macrophage phagocytosis.
Jilong Wang, Ning Lu, Zhuo Yan, Luyi Ye, Luyao Bai, Shanshan Yuan, Yuting Zhu, Yiru Xiong, Yongheng Bai, Yaping Chen, Junjie Deng   +10 more
wiley   +1 more source

Obtenção de derivado de celulose a partir do bagaço de cana-de-açúcar com potencial aplicação nas indústrias farmacêutica e cosmética

Revista de Ciências Farmacêuticas Básica e Aplicada, 2011
A tendência de se buscar o desenvolvimento de novos veículos agregando sustentabilidade e qualidade é o desafio da pesquisa farmacêutica. Assim, a busca de novas fontes de matéria-prima parece ocupar uma grande parcela dos estudos e investimentos do ...
DANYELLA MARçAL SILVA, DIEGO CASTRO MUSIAL, CLESCILA ALTMEYER, SERGIO ALEXANDRE VALENTINI   +3 more
doaj  

Irritation Potential of Propylene Glycol Herbal Extracts for Topical Application: Using as an Example

Natural Product Communications
Objective Different extraction vehicles are traditionaly used for herbal extraction. Despite its frequent use in modern cosmetic and pharmaceutical formulations, there is a lack of scientific data to support safety of propilene glycol (PG) plant extract ...
Marija Tasić-Kostov, Dragana Pavlović, Sanja Stojanović, Maja Grigorov, Stevo Najman   +4 more
doaj   +1 more source

Vehicle Routing Optimization Algorithms for Pharmaceutical Supply Chain: A Systematic Comparison

Transport and Telecommunication Journal
Abstract Nowadays, supply chain and road networks are full of complexity. Companies can differentiate themselves by offering superior customer service. Therefore, pharmaceutical distributors need to optimize route distribution for efficient and effective delivery to pharmacies, enhancing their competitiveness.
Mamoun Khadija Ait, Hammadi Lamia, Ballouti Abdessamad El, Novaes Antonio G.N., Cursi Eduardo Souza De   +4 more
openaire   +2 more sources

Case by Case Physicochemical and In Vitro/ In Vivo Biopharmaceutical Characterization of Alkyl Polyglucoside-Based Vehicles: Ketoprofen as a Model Drug

, 2010
Both the active pharmaceutical ingredient and the vehicle physicochemical characteristics are retained to be the main features responsible for favorable topical bioavailability.
S. SAVIC, M. LUKIC, R. DANIELS, I. JAKSIC, J. MILIC, S. REICHEL   +5 more
core   +1 more source

Scalable Engineering of Bio‐Manufactured Extracellular Vesicles for Selective Delivery in Ovarian Cancer Patient‐Derived Models

Advanced Science, EarlyView.
Engineered extracellular vesicles displaying Ephrin‐B2 selectively target Ephrin‐B4–expressing ovarian cancer cells, enabling precise delivery in patient‐derived models. This scalable bio‐manufacturing platform reveals a versatile strategy to exploit Ephrin signaling for highly specific therapeutic payload delivery and motivates exploration of tailored
Nihar Godbole, Andrew Lai, Alexander Quinn, Marianne Gillard, Dominic Guanzon, Katherin Scholz‐Romero, Alexis Salas‐Burgos, Bastián Lillo Dapremont, Rohan Lourie, Naven Chetty, Richard Lobb, Kate Beecher, Amy E. McCart Reed, Kaltin Ferguson, Biao Sun, Yaowu He, John D. Hooper, Carlos Salomon   +17 more
wiley   +1 more source

Caveolin‐1 Stabilizes SERCA2 to Counteract Acute Kidney Injury via Suppression of Ca2+‐Dependent Endoplasmic Reticulum Stress in Distal Tubules

Advanced Science, EarlyView.
In AKI, initial kidney injury upregulates the expression of Cav‐1, which subsequently binds to and stabilizes SERCA2 via its scaffolding domain and through deubiquitination, thereby regulating Ca2+ homeostasis and ER stress. Conversely, Cav‐1 deficiency accelerates SERCA2 degradation, triggering Ca2+ overload and ER stress, and ultimately exacerbating ...
Yan Zhang, Xin He, Hao Huang, Rong Lu, Xin Lv, Shenglan Li, Sijue Zou, Jiawei Cheng, Yiwei Xiong, Zhenghao Deng, Qiongjing Yuan, Yanyun Xie, Ling Huang, Jiaxi Pu, Shao Liu, Qianbin Li, Jie Meng, Huixiang Yang, Lijian Tao, Zhangzhe Peng   +19 more
wiley   +1 more source

Genetic Code Expanded T Cell for Controllable Immunotherapy

Advanced Science, EarlyView.
Our GCE‐CAR‐T cells enables tight, dose‐dependent, and function‐preserving control of CAR expression at the translational level through amber codon suppression and genetic incorporation of ncAA. ABSTRACT Chimeric antigen receptor (CAR)‐T cell therapy has demonstrated curative potential against hematologic malignancies, but its clinical application ...
Xue Wang, Yingao Gao, Yeyu Su, Yong Wang, Tao Liu   +4 more
wiley   +1 more source

Solving integrated problems in a pharmaceutical context: scheduling and routing of vehicles

, 2021
Ten years ago, the production unit of chemotherapy preparations of the Bretonneau CHRU (UBCO) made an average of 80 preparations per day on four chains of insulators. Today, thanks to a planning optimization software, developed in collaboration with the Computer Science Laboratory of the University of Tours and the company Eticsys, and the acquisition ...
openaire   +1 more source