Results 61 to 70 of about 919,308 (292)

Multi‐omics and low‐input proteomics profiling reveals dynamic regulation driving pluripotency initiation in early mouse embryos

FEBS Open Bio, EarlyView.
Mouse pre‐implantation development involves a transition from totipotency to pluripotency. Integrating transcriptomics, epigenetic profiling, low‐input proteomics and functional assays, we show that eight‐cell embryos retain residual totipotency features, whereas cytoskeletal remodeling regulated by the ubiquitin‐proteasome system drives progression ...
Wanqiong Li, Xi Xiao, Lingbin Qi, Chanyi Li, Sirui Song, Jiaying Qin, Zhigang Xue, Jinfeng Xue, Huaifang Li   +8 more
wiley   +1 more source

Removal of Pharmaceuticals and Personal Care Products (PPCPs) by Free Radicals in Advanced Oxidation Processes [PDF]

, 2022
Jiao Jiao, Yihua Li, Qi Song, Liujin Wang, Tianlie Luo, Changfei Gao, Lifen Liu, Sheng‐Tao Yang   +7 more
openalex   +1 more source

Dihydroorotate dehydrogenase (DHODH) regulates trophoblast syncytialization through organelle stress–induced cellular senescence

FEBS Open Bio, EarlyView.
The inhibition of mitochondrial dihydroorotate dehydrogenase (DHODH) impairs syncytialization and induces cellular senescence via mitochondrial and endoplasmic reticulum stress in human trophoblast stem cells, elevating sFlt1/PlGF levels, a hallmark of placental dysfunction in hypertensive disorders of pregnancy.
Kanoko Yoshida, Kazuya Kusama, Ayaka Horiuchi, Yu Kawaguchi, Atsuya Tsuru, Mikihiro Yoshie, Kazuhiro Tamura   +6 more
wiley   +1 more source

Estimating the effects of non-pharmaceutical interventions on COVID-19 in Europe [PDF]

, 2020
Seth Flaxman, Swapnil Mishra, Axel Gandy, H. Juliette T. Unwin, Thomas A. Mellan, Helen Coupland, Charles Whittaker, Harrison Zhu, Tresnia Berah, Jeffrey W. Eaton, Mélodie Monod, Pablo N. Perez‐Guzman, Nora Schmit, Lucia Cilloni, Kylie E. C. Ainslie, Marc Baguelin, Adhiratha Boonyasiri, Olivia Boyd, Lorenzo Cattarino, Laura Cooper, Zulma M. Cucunubá, Gina Cuomo-Dannenburg, Amy Dighe, Bimandra A Djaafara, Ilaria Dorigatti, Sabine van Elsland, Richard G. FitzJohn, Katy A. M. Gaythorpe, Lily Geidelberg, Nicholas C. Grassly, William D. Green, Timothy B. Hallett, Arran Hamlet, Wes Hinsley, B Jeffrey, Edward Knock, Daniel J. Laydon, Gemma Nedjati‐Gilani, Pierre Nouvellet, Kris V. Parag, Igor Siveroni, Hayley A Thompson, Robert Verity, Erik Volz, Caroline E. Walters, Haowei Wang, Yuanrong Wang, Oliver J. Watson, Peter Winskill, Xiaoyue Xi, Patrick Walker, Azra C. Ghani, Christl A. Donnelly, Steven Riley, Michaela Vollmer, Neil M. Ferguson, Lucy Okell, Samir Bhatt   +57 more
openalex   +1 more source

Mathematical epidemiological modeling and analysis of monkeypox dynamism with non-pharmaceutical intervention using real data from United Kingdom [PDF]

, 2023
Mercy Ngungu, Emmanuel Addai, A. A. Adeniji, Umar Muhammad Adam, Kayode Oshinubi   +4 more
openalex   +1 more source

Meta‐analysis fails to show any correlation between protein abundance and ubiquitination changes

FEBS Open Bio, EarlyView.
We analyzed over 50 published proteomics datasets to explore the relationship between protein levels and ubiquitination changes across multiple experimental conditions and biological systems. Although ubiquitination is often associated with protein degradation, our analysis shows that changes in ubiquitination do not globally correlate with changes in ...
Nerea Osinalde, Unai Alduntzin, Gorka Prieto, Ugo Mayor   +3 more
wiley   +1 more source

IPRs, technological and industrial development and growth: the case of the pharmaceutical industry [PDF]

, 2007
Discussion of effects of TRIPs on pharmaceuticals in developing ...
Laforgia, Francesco, Montobbio, Fabio, Orsenigo, Luigi   +2 more
core  

Promiscuous stimulation of HSP70 ATPase activity by parasite‐derived J‐domains

FEBS Open Bio, EarlyView.
The malaria parasite Plasmodium falciparum exports three highly homologous yet functionally divergent J‐domain proteins into human erythrocytes. Here, we show that J‐domains isolated from all three proteins effectively stimulate the ATPase activity of both endogenous host and exported parasite HSP70 chaperones.
Julian Barth, Moritz Koch, Le‐Han Rössner, Johanna Eichhorn, Denys Pogoryelov, Matthias P. Mayer, Jude M. Przyborski   +6 more
wiley   +1 more source

Risk assessment of heavy metal pollution in agricultural soil surrounding a typical pharmaceutical manufacturing complex [PDF]

, 2023
Qu Su, Xiaofang Zhang, Yao Zhang, Gang Sun, Zheyong Li, Luojing Xiang, Junxiong Cai   +6 more
openalex   +1 more source

Erythropoietin modulates hepatic inflammation, glucose homeostasis, and soluble epoxide hydrolase and epoxides in high‐fat diet‐induced obese mice

FEBS Open Bio, EarlyView.
Erythropoietin administration suppresses hepatic soluble epoxide hydrolase (sEH) expression, leading to increased CYP‐derived epoxides. This is associated with a shift in hepatic macrophage polarization characterized by reduced M1 markers and increased M2 markers, along with reduced hepatic inflammation, suppressed hepatic lipogenesis, and attenuated ...
Takeshi Goda, Satoru Sugimoto, Chiharu Cho, Madoka Konishi, Nozomi Inoue, Satoshi Miyagaki, Yasuhiro Kawabe, Takuro Okamura, Masahide Hamaguchi, Hisakazu Nakajima, Michiaki Fukui, Masakazu Shinohara, Tomoko Iehara   +12 more
wiley   +1 more source