Results 11 to 20 of about 97,439 (147)

Analytical Methods Used for the Detection and Quantification of Benzodiazepines

Journal of Analytical Methods in Chemistry, 2019
The prescription of psychotropic drugs, especially benzodiazepines (BZDs), occupies a preponderant place in the management of mental illnesses. Indeed, the BZDs have been used in different therapeutic areas including insomnia, anxiety, seizure disorders,
Zidane Qriouet, Zineb Qmichou, Nadia Bouchoutrouch, Hassan Mahi, Yahia Cherrah, Hassan Sefrioui   +5 more
doaj   +2 more sources

Editorial: Insights in thrombosis: 2022 [PDF]

Frontiers in Cardiovascular Medicine, 2023
Jonathan Douxfils, Jonathan Douxfils, Hugo ten Cate, Roberto Pola   +3 more
doaj   +2 more sources

Quantitative impact of pre-analytical process on plasma uracil when testing for dihydropyrimidine dehydrogenase deficiency. [PDF]

Br J Clin Pharmacol, 2023
Aims Determining dihydropyrimidine dehydrogenase (DPD) activity by measuring patient's uracil (U) plasma concentration is mandatory before fluoropyrimidine (FP) administration in France. In this study, we aimed to refine the pre‐analytical recommendations for determining U and dihydrouracil (UH2) concentrations, as they are essential in reliable DPD ...
Maillard M, Launay M, Royer B, Guitton J, Gautier-Veyret E, Broutin S, Tron C, Le Louedec F, Ciccolini J, Richard D, Alarcan H, Haufroid V, Tafzi N, Schmitt A, Etienne-Grimaldi MC, Narjoz C, Thomas F, Groupe de Pharmacologie Clinique Oncologique (GPCO).   +17 more
europepmc   +2 more sources

Evaluating Use of Artificial Intelligence for Drug Exposure and Effect Prediction [PDF]

Kidney International Reports
Olivier Le Tilly, Jean-Baptiste Woillard
doaj   +2 more sources

La métabolomique par RMN et ses applications en biologie végétale, toxicologie et médecine

, 2012
National audienceCet article présente les principes ainsi que les outils analytiques et chimiométriques qui sont au cœur du développement des approches d'analyse métabolomique par RMN. Il en illustre les applications variées au travers d'exemples choisis
Shintu, Laetitia, Canlet, Cécile, Elena-Herrmann, Bénédicte   +2 more
core   +6 more sources

Efficacy and safety of intravenous bevacizumab on severe bleeding associated with hemorrhagic hereditary telangiectasia: A national, randomized multicenter trial

Journal of Internal Medicine, Volume 294, Issue 6, Page 761-774, December 2023., 2023
Abstract Background Bevacizumab—a humanized monoclonal antibody—has been widely used to treat patients with hereditary hemorrhagic telangiectasia (HHT), but no randomized trial has yet been conducted. Methods This study is a double‐blind multicenter randomized phase 2 trial with a 1:1 active‐treatment‐to‐placebo ratio. We included patients over the age
Sophie Dupuis‐Girod, Sophie Rivière, Christian Lavigne, Anne‐Emmanuelle Fargeton, Brigitte Gilbert‐Dussardier, Vincent Grobost, Vanessa Leguy‐Seguin, Hélène Maillard, Shirine Mohamed, Evelyne Decullier, Adeline Roux, Lorraine Bernard, Jean‐Christophe Saurin, Nicolas Saroul, Frédéric Faure, Cesar Cartier, Romain Altwegg, Laurent Laccourreye, Frédéric Oberti, Marjolaine Beaudoin, Carole Dhelens, Céline Desvignes, Nicolas Azzopardi, Gilles Paintaud, Ruben Hermann, Thierry Chinet   +25 more
wiley   +1 more source

Alternative to animal experimentation in pharmacology teaching: Development and validation of an equivalent digital learning tool

Pharmacology Research &Perspectives, Volume 10, Issue 1, February 2022., 2022
This study reveals a good acceptance of the digital tool and good motivation towards digital method in all of the students. It found equivalent the two teaching methods, digital and traditional in terms of motivation and knowledge acquisition. Abstract Regarding animal experiments in pharmacology teaching, ethical considerations led us to examine an ...
Roland Lawson, Sophie Leymarie, Claire Nikitopoulos, Antoine Humeau, Hichem Bouchenaki, Jean‐Luc Duroux, Laurent Fourcade, Sandrine Karam, Nicolas Picard, Claire Demiot   +9 more
wiley   +1 more source

High‐Fat Diet Modulates Hepatic Amyloid β and Cerebrosterol Metabolism in the Triple Transgenic Mouse Model of Alzheimer’s Disease

Hepatology Communications, Volume 5, Issue 3, Page 446-460, March 2021., 2021
Long‐term high‐fat diet–induced changes in liver function impact peripheral AD features and should be considered during development of biomarkers or therapeutic targets. Obesity and diabetes are strongly associated not only with fatty liver but also cognitive dysfunction. Moreover, their presence, particularly in midlife, is recognized as a risk factor
Cristina R. Bosoi, Milène Vandal, Marine Tournissac, Manon Leclerc, Hortense Fanet, Patricia L. Mitchell, Mélanie Verreault, Jocelyn Trottier, Jessica Virgili, Cynthia Tremblay, H. Robert Lippman, Jasmohan S. Bajaj, Olivier Barbier, André Marette, Frédéric Calon   +14 more
wiley   +1 more source

Phenolic Compound Analysis and Pharmacological Screening of Vitex agnus-castus Functional Parts

BioMed Research International, Volume 2021, Issue 1, 2021., 2021
Vitex agnus-castus is a medicinal plant of the Verbenaceae family, widely used in traditional medicine. This study is aimed at investigating the functional variability of phenolic compounds in different parts (leaves, stems, flowers, roots, and seeds) of Vitex agnus-castus methanolic extracts and at assessing their in vitro antidiabetic, antioxidant ...
Assia Berrani, Ilias Marmouzi, Abdelhakim Bouyahya, Mourad Kharbach, Maha El Hamdani, Meryem El Jemli, Aicha Lrhorfi, Meryem Zouarhi, My El Abbes Faouzi, Rachid Bengueddour, Muhammad Hassham Hassan Bin Asad   +10 more
wiley   +1 more source

Should samples be weighted to decrease selection bias in online surveys during the COVID-19 pandemic? Data from seven datasets

BMC Medical Research Methodology, 2022
Background Online surveys have triggered a heated debate regarding their scientific validity. Many authors have adopted weighting methods to enhance the quality of online survey findings, while others did not find an advantage for this method.
Chadia Haddad, Hala Sacre, Rony M. Zeenny, Aline Hajj, Marwan Akel, Katia Iskandar, Pascale Salameh   +6 more
doaj   +1 more source