Many patients with urothelial cancer do not benefit from treatment with pembrolizumab, while at risk of severe side effects. Changes in the levels of circulating tumor DNA early during treatment, measured by a simple and affordable assay that can be easily implemented in the clinic, can be used as a prognostic tool to identify these patients.
Youssra Salhi +14 more
wiley +1 more source
Description of a Pharmacist-Led Mobile Health Clinic to Fill Primary Care Coverage in a Medically Underserved Rural Area. [PDF]
Eddy E +5 more
europepmc +1 more source
MITF maintains genome stability in nonmelanocyte lineages
MITF is essential for melanocyte survival and acts as an oncogene in 10%–20% of melanomas. We show that MITF depletion causes genome instability in nonmelanocytic cells, leading to LATS2‐mediated P53 activation, cell cycle arrest, and apoptosis. This study highlights the role of MITF as a genome maintenance factor beyond the melanocyte lineage. Created
Drifa H. Gudmundsdottir +13 more
wiley +1 more source
Emerging advancements and expanding technological scope of education and practices in pharmacy and pharmaceutical sciences. [PDF]
Barar J +5 more
europepmc +1 more source
The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka +9 more
wiley +1 more source
Impact of a psychiatric pharmacist on an inpatient psychiatry consultation liaison service. [PDF]
Ferro H, Dress J.
europepmc +1 more source
Antibiotic prescribing by non-medical healthcare professionals in primary care: a systematic review of effects on antibiotic use, patient experience, interprofessional relationships and job satisfaction. [PDF]
Veillard H, Lalani M, Mays N, Glover RE.
europepmc +1 more source
The impact of hospital pharmacists' psychological contracts on medication adherence management: The mediating role of job burnout. [PDF]
Luo Y +8 more
europepmc +1 more source

