Relationships among nitrous oxide exposure, neurological injury and biomarkers
British Journal of Clinical Pharmacology, EarlyView.Aims Recreational nitrous oxide (N2O) misuse is an increasing public health problem associated with functional cobalamin (B12) deficiency and severe neurological complications. Despite growing recognition of its harms, the dose–response relationship and clinical value of biomarkers remain unclear.
Laxna Bhujel +6 more
wiley +1 more source
Pharmacogenomics of dolutegravir: A scoping review of evidence, gaps and clinical implications
British Journal of Clinical Pharmacology, EarlyView.Dolutegravir underpins modern first‐ and second‐line HIV treatment regimens; however, interindividual variability in its disposition and tolerability presents challenges for optimal use. This scoping review mapped current evidence on the pharmacogenomics of dolutegravir, focusing on pharmacokinetics and pharmacodynamics, and methodological limitations ...
Ronald Kiguba +2 more
wiley +1 more source
Comments on "Safety and pharmacology of AMY109, a long-acting anti-interleukin-8 antibody, for endometriosis: a double-blind, randomized phase 1 trial". [PDF]
F S RepDokania S, Aphale P, Shekhar H.
europepmc +1 more source
A British Pharmacological Society Position Statement on Medications in Pregnancy and Lactation
British Journal of Clinical Pharmacology, EarlyView.
Agnesa Mustafa +14 more
wiley +1 more source
Pharmacometric evaluation of pre‐referral rectal artesunate in children with severe malaria
British Journal of Clinical Pharmacology, EarlyView.Aims Parenteral artesunate is the preferred first‐line treatment for severe malaria. Pre‐referral rectal artesunate suppositories are recommended where parenteral treatment is inaccessible. In this study, we compared dihydroartemisinin exposure and model‐predicted early parasite clearance following rectal artesunate and intravenous artesunate in ...
Ayorinde Adehin +6 more
wiley +1 more source
Safety, Pharmacokinetics, and Pharmacodynamics of Fixed-dose, Subcutaneous, and Intravenous Administration of VEL-101, an Anti-CD28 PEGylated Monoclonal Antibody Fragment, in Healthy Participants: A Randomized, Double-blind, Placebo-controlled, Dose Escalation, Phase 1 Study. [PDF]
TransplantationTremblay S +7 more
europepmc +1 more source
An ETH‐LAD trip with unfavourable consequences: A case report
British Journal of Clinical Pharmacology, EarlyView.Numerous analogues of the psychedelic and internationally controlled hallucinogen LSD have been described; however, only a limited number have been systematically investigated. This report presents the first case with an analytically confirmed ingestion of ETH‐LAD (6‐ethyl‐6‐nor‐lysergic acid diethylamide), the N‐ethyl derivative of LSD.
Johannes Nadler +6 more
wiley +1 more source
Phase Ib, multicentre, open-label, dose-escalation study to evaluate the safety, tolerability, pharmacokinetics and pharmacodynamics of subcutaneously administered mosunetuzumab in participants with systemic lupus erythematosus. [PDF]
Lupus Sci MedMartins E +13 more
europepmc +1 more source
Biopharmaceutics &Drug Disposition, EarlyView.Pharmacokinetic interactions between Echinacea and two antiviral drugs, favipiravir and atazanavir, were assessed in rats. The findings suggest that Echinacea does not significantly affect the pharmacokinetics of favipiravir and atazanavir. These results provide preliminary evidence that concurrent use of Echinacea with these antiviral drugs may be ...
Siva Nageswara Rao Gajula +4 more
wiley +1 more source