Results 141 to 150 of about 101,624 (260)

Sex impact on biomarkers, pharmacokinetics and pharmacodynamics

, 2016
Sex is one of several factors influencing pharmacological responses, but research on its effects on pharmacokinetics and pharmacodynamics, although emerging remarkably, remains poor and contains many methodological issues.
CAMPESI, Ilaria, FRANCONI, Flavia
core  

Pharmacokinetics, pharmacodynamics, and safety of lesinurad, a selective uric acid reabsorption inhibitor, in healthy adult males

, 2015
Zancong Shen, Colin Rowlings, Brad Kerr, Vijay Hingorani, Kimberly Manhard, Barry Quart, Li-Tain Yeh, Chris Storgard Ardea Biosciences, Inc. (a member of the AstraZeneca group), San Diego, CA, USA Abstract: Lesinurad is a selective uric acid ...
Yeh LT, Shen Z, Manhard K, Storgard C, Rowlings C, Kerr B, Hingorani V, Quart B   +7 more
core  

Alzheimer’s disease: causes, symptoms and pharmacotherapy

Current Issues in Pharmacy and Medical Sciences, 2010
AD is the most common form of dementia characterized by noticeable decline in cognitive functions. There are several theories explaining the neuronal degeneration in AD including the β-amyloid aggregation, protein τ hyperphosphorylation, oxidative ...
Kinga Tendera, Marta Kruk, Grażyna Biała   +2 more
doaj  

Evaluation of pharmacokinetics and pharmacodynamics of sinomenine-hyaluronic acid conjugate after intra-articular administration for osteoarthritis treatment

, 2019
Jie Liu,1,2,* Huarong Shao,1,* Shaoying Fang,1 Yanling Cheng,1 Peixue Ling,1,3 Jianying Chen1,3 1Key Laboratory of Biopharmaceuticals of Shandong Province, Shandong Academy of Pharmaceutical Sciences, Jinan, Shandong Province, China; 2Shandong ...
Liu J, Shao H, Chen J, Fang S, Ling P, Cheng Y   +5 more
core  

In Silico to In Cerebro—Development of the Orexin Receptor Antagonist “Photorexant” for Photomodulation In Vitro and in Mouse Brains

Angewandte Chemie International Edition, EarlyView.
Following a structure‐based design approach, photoswitchable derivatives of the FDA‐approved drug suvorexant were designed, docked, synthesized, and characterized pharmacologically at the orexin 1 and 2 receptors (OX1R and OX2R). Optimized “photorexant” showed up to an 11‐fold difference in IC50 between photoisomers, enabled dynamic and reversible ...
Marcus Angermann, Marie H. Deventer, Vicente Ledesma‐Martin, Nuno Martinho, Alix Flake, Silvia Mori, Angel Nuñez, Jaime Pignatelli, Rita C. Guedes, Christophe P. Stove, Michael Decker   +10 more
wiley   +1 more source

Pharmacokinetics, pharmacodynamics, and tolerability of verinurad, a selective uric acid reabsorption inhibitor, in healthy Japanese and non-Asian male subjects

, 2018
Jesse Hall,1 Michael Gillen,2 Sha Liu,1 Jeffrey N Miner,1 Shakti Valdez,1 Zancong Shen,1 Caroline Lee1 1Ardea Biosciences, Inc., San Diego, CA, USA; 2AstraZeneca, Gaithersburg, MD, USA Purpose: Verinurad (RDEA3170) is a selective uric acid reabsorption
Lee C, Shen Z, Miner JN, Hall J, Gillen M, Valdez S, Liu S   +6 more
core  

Follicle Stimulating Hormone in Cattle Breeding: Fundamentals, Innovations, and Scope

Animal Research and One Health, EarlyView.
FSH is crucial in cattle reproduction, with exogenous administration enhancing breeding and embryo production. Recombinant FSH offers advantages over pituitary‐extracted variants, including fewer injections, reduced stress, and safer production. These innovations improve breeding efficiency, optimize reproductive outcomes, and contribute to sustainable
Muhammad Shahzad, Hubdar Ali Kolachi, Jesse Oluwaseun Ayantoye, Xiaomeng Zhang, Muhammad Usman Mehmood, Rajilan Hilali Shanga, Pengcheng Wan, Xueming Zhao   +7 more
wiley   +1 more source

Use of Clotrimazole in Finfish Aquaculture: Mechanistic Insights, Limitations, and Future Directions for Antifungal Therapy

Animal Research and One Health, EarlyView.
This review critically evaluates clotrimazole as a potential antifungal for finfish aquaculture, highlighting strong mechanistic and in vitro efficacy against aquatic mycoses alongside major gaps in in vivo evidence, toxicokinetics, residue safety, and environmental risk, outlining priorities for responsible therapeutic development and regulatory ...
Arya Sen, Debashri Mondal, Thangapalam Jawahar Abraham   +2 more
wiley   +1 more source

Effects of NOS inhibitors and a NO precursor on the expression of tolerance to diazepam-induced motor impairment in mice

Current Issues in Pharmacy and Medical Sciences
The effect of nonselective NOS inhibitors: NG-nitro-L-arginine (L-NOARG) and NG-nitro-L-arginine methyl ester (L-NAME) and a NO precursor, L-arginine on the expression of tolerance to the diazepam (DZ)-induced motor impairment was investigated in this ...
Jolanta Orzelska, Sylwia Talarek, Joanna Listos, Sylwia Fidecka   +3 more
doaj  

Morphine versus hydromorphone pharmacokinetic <i>vs</i>. pharmacodynamic variabilities. [PDF]

Ann Transl Med
Meissner K, Olofsen E, Dahan A, Kharasch ED.   +3 more
europepmc   +1 more source