Results 201 to 210 of about 187,044 (318)

High Protein Binding and Cidal Activity against Penicillin-Resistant S. pneumoniae: A Cefditoren In Vitro Pharmacodynamic Simulation

, 2008
David Sevillano, Lorenzo Aguilar, Luís Alou, María-José Giménez, Natalia González, M. Torrico, Fabio Cafini, Asunción Fenoll, Pilar Coronel, J. Prieto   +9 more
openalex   +2 more sources

Model‐informed precision dosing of carboplatin in cancer patients by leveraging myelosuppression data from electronic health records

British Journal of Clinical Pharmacology, EarlyView.
Abstract Aims This study aimed to develop and validate a population pharmacokinetic‐pharmacodynamic (pop‐PK‐PD) model to describe carboplatin‐induced myelosuppression in cancer patients and support dose individualization. Methods Data from 580 cancer patients treated with carboplatin at Amsterdam UMC between 2019 and 2022 were used for model ...
Alessandro De Carlo, Elena Maria Tosca, Mirjam Crul, Tim Schutte, Lia van Zuijlen, Idris Bahce, Medhat M. Said, Jan Buter, Harmen Huls, Paolo Magni, Imke Bartelink   +10 more
wiley   +1 more source

Eravacycline pharmacokinetics/pharmacodynamics in the hollow fiber system model of <i>Mycobacterium abscessus</i> lung disease. [PDF]

Microbiol Spectr
Singh S, Shrivastava A, Boorgula GD, Long MC, Robbins B, Gumbo T, Srivastava S.   +6 more
europepmc   +1 more source

Hypnotic doses of fazamorexant induced less impairment on balance and cognition than zolpidem in healthy younger and elderly individualse

British Journal of Clinical Pharmacology, EarlyView.
Aims Fazamorexant is a dual orexin receptor antagonist being developed for the treatment of insomnia. This study aims to determine the dose‐exposure‐response relationship of single‐dose fazamorexant vs. zolpidem in young adult and elderly healthy Chinese volunteers. Methods This single‐centre, randomized, double‐blind, double‐dummy, placebo‐ and active‐
Chen Xia, Huang Xingxing, Jin Lu, Wang Ruwei   +3 more
wiley   +1 more source

Editorial: The impact of pharmacokinetics and pharmacodynamics on antimicrobial stewardship. [PDF]

Front Cell Infect Microbiol
Ture Z, Alp Meşe E, Alves J, Roger C, Zeenny RM.   +4 more
europepmc   +1 more source

Paediatric development of radiopharmaceutical imaging agents and radioligand therapeutics

British Journal of Clinical Pharmacology, EarlyView.
Abstract This review focuses on the development of radiopharmaceutical imaging agents and radioligand therapeutics for paediatric use. Nuclear medicine plays an important role in the diagnosis and treatment of various childhood conditions, including cancers, infections and brain disorders.
Justin L. Hay, Amandine Manon, Hunter Stephens, S. Y. Amy Cheung, Bart de Keizer, Erik T. te Beek   +5 more
wiley   +1 more source

Safety, Tolerability, Pharmacokinetics, and Pharmacodynamics of the Oral TYK2 Inhibitor D-2570 in Healthy Subjects: A First-in-Human Phase I Study. [PDF]

Clin Transl Sci
Wang M, Zhang Q, Shi Z, Zhang L, Pan J.
europepmc   +1 more source

Clinical pharmacology and prescribing education: An updated medical school curriculum from the British Pharmacological Society

British Journal of Clinical Pharmacology, EarlyView.
Aims Prescribing is a complex, essential skill that doctors must acquire to practice medicine safely and effectively. The British Pharmacological Society has historically provided a core curriculum to guide clinical pharmacology and prescribing education in UK medical schools.
Dagan O. Lonsdale, Clare Guilding, Jennifer Koenig, Michael Okorie, Reecha Sofat, Simon Maxwell   +5 more
wiley   +1 more source

Antagonistic interaction between posaconazole and olorofim in a murine model of invasive pulmonary aspergillosis. [PDF]

J Antimicrob Chemother
Darlow CA, Farrington N, Märtson AG, Johnson A, McEntee L, Horner I, Stevenson A, Jimenez-Valverde A, Unsworth J, Das S, Hope W.   +10 more
europepmc   +1 more source

P-1222. Population Pharmacokinetic/Pharmacodynamic Analysis of Cefiderocol in Chinese Patients with Complicated Urinary Tract Infections [PDF]

S H Li, Shuyan Yu, Xiaojie Wu, Jinjie He, Haijing Yang, Takayuki Katsube, Ningning Xie, Haomiao Dou, Juan Ye, Jing Zhang   +9 more
openalex   +1 more source