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Pharmacoepidemiology: An Overview
Journal of Clinical Medicine, 2023 The aims of this review are to provide a comprehensive overview of the definition and scope of pharmacoepidemiology, to summarize the study designs and methodologies used in the field, to discuss the future trends in the field and new methodologies to address bias and confounding, and finally to give some recommendations to clinicians interested in ...
Mònica Sabaté, Eva Montané
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Building transparency and reproducibility into the practice of pharmacoepidemiology and outcomes research. [PDF]
Am J Epidemiol, 2023 Real-world evidence (RWE) studies are increasingly used to inform policy and clinical decisions. However, there remain concerns about the credibility and reproducibility of RWE studies.
Wang SV, Pottegård A.
europepmc +2 more sources
Pitfalls of pharmacoepidemiology [PDF]
BMJ, 2000 EDITOR—Farmer et al cited several “crucial differences” between a study they published and our recent study on the risk of venous thromboembolism associated with third generation oral contraceptives compared with oral contraceptives containing levonorgestrel using the same data source, the General Practice Research Database.1-3 We agree that it is ...
D C Skegg
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Core Concepts in Pharmacoepidemiology: New-User Designs. [PDF]
Pharmacoepidemiol Drug SafIn this article, we review the history and key reasons for new‐user comparisons in pharmacoepidemiology, highlighting the target trial framework as a unifying framework.
Her QL +4 more
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The Inappropriate Use of GLP-1 Analogs: Reflections from Pharmacoepidemiology
PharmacoepidemiologyGlucagon-like peptide-1 receptor agonists (GLP-1 RAs) have emerged as a potent therapeutic option for the management of obesity, demonstrating exceptional efficacy in several large-scale clinical trials.
Sofía Echeverry-Guerrero +7 more
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Pharmacoepidemiology—an Irish perspective [PDF]
Pharmacoepidemiology and Drug Safety, 2001 AbstractThe Irish healthcare system is a mixture of free, state‐supported and private medicine. The state‐supported General Medical Services (GMS) scheme maintains a large prescription database, which has been used to conduct pharmacoepidemiological studies in Ireland.
David Williams, J. Feely
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Core concepts in pharmacoepidemiology: Key biases arising in pharmacoepidemiologic studies
Pharmacoepidemiology and Drug Safety, 2022 AbstractPharmacoepidemiology has an increasingly important role in informing and improving clinical practice, drug regulation, and health policy. Therefore, unrecognized biases in pharmacoepidemiologic studies can have major implications when study findings are translated to the real world.
Emily K. Acton +2 more
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Core Concepts: Self-Controlled Designs in Pharmacoepidemiology. [PDF]
Pharmacoepidemiol Drug SafOne of the key challenges in pharmacoepidemiological studies is that of uncontrolled confounding, which occurs when confounders are poorly measured, unmeasured or unknown.
Bots SH +6 more
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Drug exposure misclassification in pharmacoepidemiology: Sources and relative impact [PDF]
Pharmacoepidemiology and Drug Safety, 2021 Drug exposure assessment based on dispensing data can be misclassified when patients do not adhere to their therapy or when information about over‐the‐counter drugs is not captured in the study database.
Mirjam Hempenius +4 more
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Clinical Therapeutics, 2019 At the time of their marketing authorization, the effects of drugs and especially their efficacy have been mostly studied in randomized controlled clinical trials (RCT), comparing them to placebo or to existing drugs. However, RCT are by nature limited in their extent, and the often stringent inclusion and exclusion criteria destined to provide for ...
Nicholas, Moore +2 more
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