Results 271 to 280 of about 39,211 (299)
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The Journal of Clinical Pharmacology, 2007
The human genome project and related research initiatives have enabled the identification of a significant number of genetic variants that are predictive of drug response and outcome (pharmacogenomic biomarkers). As yet, incorporation of routine pharmacogenomic testing into clinical practice has been relatively modest.
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The human genome project and related research initiatives have enabled the identification of a significant number of genetic variants that are predictive of drug response and outcome (pharmacogenomic biomarkers). As yet, incorporation of routine pharmacogenomic testing into clinical practice has been relatively modest.
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Pharmacogenomics, 2004
It is well known that genetic polymorphisms, such as SNPs, vary between races so that not only Western populations' pharmacogenetic/pharmacogenomic data but also data from Asians are viewed as vital to drug development and clinical practice. For this report, the current state of pharmacogenetic/pharmacogenomic-related activities in five Asian countries
Mieko, Tamaoki +2 more
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It is well known that genetic polymorphisms, such as SNPs, vary between races so that not only Western populations' pharmacogenetic/pharmacogenomic data but also data from Asians are viewed as vital to drug development and clinical practice. For this report, the current state of pharmacogenetic/pharmacogenomic-related activities in five Asian countries
Mieko, Tamaoki +2 more
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Microarrays in Pharmacogenomics
Journal of Biopharmaceutical Statistics, 2004DNA array technology provides tools for studying the expression profiles of a large number of distinct genes simultaneously.
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Pharmacogenomics and schizophrenia
European Journal of Pharmacology, 2000Although antipsychotic drugs are effective in alleviating schizophrenic symptoms, individual differences in patient response suggest that genetic components play a major role, and pharmacogenetic studies have indicated the possibility for a more individually based pharmacotherapy. The new field of pharmacogenomics, which focuses on genetic determinants
Y, Kawanishi, H, Tachikawa, T, Suzuki
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Developmental pharmacogenomics
Pediatric Anesthesia, 2011SummaryInterindividual variability in the disposition and action associated with similar doses of a given medication is an inherent characteristic of both adult and pediatric populations. Genotype–phenotype relationships in infants and children must take into account the role that ontogeny plays in producing variability in both pharmacokinetics and ...
Kathleen A, Neville +3 more
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Pharmacogenomics, 2009
Genetic polymorphisms for histamine-metabolizing enzymes are responsible for interindividual variation in histamine metabolism and are associated with diverse diseases. Initial reports on polymorphisms of histamine-related genes including those coding for the enzymes histidine decarboxylase (HDC), diamine oxidase (ABP1) and histamine N ...
Elena, García-Martín +4 more
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Genetic polymorphisms for histamine-metabolizing enzymes are responsible for interindividual variation in histamine metabolism and are associated with diverse diseases. Initial reports on polymorphisms of histamine-related genes including those coding for the enzymes histidine decarboxylase (HDC), diamine oxidase (ABP1) and histamine N ...
Elena, García-Martín +4 more
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Pharmacogenomics in Anesthesia
Anesthesiology Clinics, 2017A significant number of commonly administered medications in anesthesia show wide clinical interpatient variability. Some of these include neuromuscular blockers, opioids, local anesthetics, and inhalation anesthetics. Individual genetic makeup may account for and predict cardiovascular outcomes after cardiac surgery. These interactions can manifest at
Ramsey, Saba +2 more
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The ethics of pharmacogenomics
Monash Bioethics Review, 2004Of the future technologies arising from the Human Genome Project, pharmacogenomics will probably be the first to have a widespread impact on the everyday practice of medicine. This technology offers great benefits but also presents some difficult ethical challenges.
David, Neil, Jillian, Craigie
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Immunology and Allergy Clinics of North America, 2005
It is expected that future treatments will be preceded by genetic tests to prescribe the most effect asthma medication while lowering the risk of adverse side effects. However, it will not be necessary to describe all the genetic determinants affecting drug response to apply pharmacogenomics to asthma therapy.
Gregory A, Hawkins +2 more
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It is expected that future treatments will be preceded by genetic tests to prescribe the most effect asthma medication while lowering the risk of adverse side effects. However, it will not be necessary to describe all the genetic determinants affecting drug response to apply pharmacogenomics to asthma therapy.
Gregory A, Hawkins +2 more
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Pharmacogenomics of Cyclooxygenases
Pharmacogenomics, 2015Cyclooxygenases (COX-1 and COX-2) are key enzymes in several physiopathological processes. Many adverse drugs reactions to NSAIDs are attributable to COX-inhibition. The genes coding for these enzymes (PTGS1 and PTGS2) are highly variable, and variations in these genes may underlie the risk of developing, or the clinical evolution of, several diseases ...
José A G, Agúndez +3 more
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