Results 271 to 280 of about 38,200 (304)
Some of the next articles are maybe not open access.
The Journal of Clinical Pharmacology, 2007
The human genome project and related research initiatives have enabled the identification of a significant number of genetic variants that are predictive of drug response and outcome (pharmacogenomic biomarkers). As yet, incorporation of routine pharmacogenomic testing into clinical practice has been relatively modest.
openaire +2 more sources
The human genome project and related research initiatives have enabled the identification of a significant number of genetic variants that are predictive of drug response and outcome (pharmacogenomic biomarkers). As yet, incorporation of routine pharmacogenomic testing into clinical practice has been relatively modest.
openaire +2 more sources
Microarrays in Pharmacogenomics
Journal of Biopharmaceutical Statistics, 2004DNA array technology provides tools for studying the expression profiles of a large number of distinct genes simultaneously.
openaire +2 more sources
The pharmacogenomics of epilepsy
Expert Review of Neurotherapeutics, 2015Genetic factors contribute to the high interindividual variability in response to antiepileptic drugs. However, most genetic markers identified to date have limited sensitivity and specificity, and the value of genetic testing in guiding antiepileptic drug (AED) therapy is limited.
FRANCO, VALENTINA, PERUCCA, EMILIO
openaire +3 more sources
Expert Opinion on Pharmacotherapy, 2009
Circulatory disease accounts for fifteen million deaths each year, of which stroke accounts for four and a half million- with an estimated nine million stroke survivors annually. The overall incidence rate of stroke is 2 to 2.5 per thousand adults with an approximate prevalence of 5 per thousand and an estimated 5-year risk of stroke recurrence of 15 ...
Billeci AM +2 more
openaire +3 more sources
Circulatory disease accounts for fifteen million deaths each year, of which stroke accounts for four and a half million- with an estimated nine million stroke survivors annually. The overall incidence rate of stroke is 2 to 2.5 per thousand adults with an approximate prevalence of 5 per thousand and an estimated 5-year risk of stroke recurrence of 15 ...
Billeci AM +2 more
openaire +3 more sources
Pharmacogenomics in Anesthesia
Anesthesiology Clinics, 2017A significant number of commonly administered medications in anesthesia show wide clinical interpatient variability. Some of these include neuromuscular blockers, opioids, local anesthetics, and inhalation anesthetics. Individual genetic makeup may account for and predict cardiovascular outcomes after cardiac surgery. These interactions can manifest at
Ramsey, Saba +2 more
openaire +2 more sources
The ethics of pharmacogenomics
Monash Bioethics Review, 2004Of the future technologies arising from the Human Genome Project, pharmacogenomics will probably be the first to have a widespread impact on the everyday practice of medicine. This technology offers great benefits but also presents some difficult ethical challenges.
David, Neil, Jillian, Craigie
openaire +2 more sources
Immunology and Allergy Clinics of North America, 2005
It is expected that future treatments will be preceded by genetic tests to prescribe the most effect asthma medication while lowering the risk of adverse side effects. However, it will not be necessary to describe all the genetic determinants affecting drug response to apply pharmacogenomics to asthma therapy.
Gregory A, Hawkins +2 more
openaire +2 more sources
It is expected that future treatments will be preceded by genetic tests to prescribe the most effect asthma medication while lowering the risk of adverse side effects. However, it will not be necessary to describe all the genetic determinants affecting drug response to apply pharmacogenomics to asthma therapy.
Gregory A, Hawkins +2 more
openaire +2 more sources
Pharmacogenomics of Cyclooxygenases
Pharmacogenomics, 2015Cyclooxygenases (COX-1 and COX-2) are key enzymes in several physiopathological processes. Many adverse drugs reactions to NSAIDs are attributable to COX-inhibition. The genes coding for these enzymes (PTGS1 and PTGS2) are highly variable, and variations in these genes may underlie the risk of developing, or the clinical evolution of, several diseases ...
José A G, Agúndez +3 more
openaire +2 more sources
Ethnopsychopharmacology and Pharmacogenomics
2013Significant differences in response to psychotropic drugs are observed in various ethnic and cultural groups. Ethnopsychiatry is the study of how culture and genetic differences in human groups determine and influence the response to psychotropic agents. Meanwhile, pharmacogenomics studies the influence of genetic variations in the response of patients
openaire +2 more sources
Pharmacogenomics, 2002
Pharmacogenomics, the study of the association between genetics and drug response, is a rapidly growing field in human genetics. At a recent IBC Life Sciences conference in London, ‘SNPs and Pharmacogenomics,’ speakers emphasized the potential of pharmacogenomics to revolutionize traditional drug discovery and development processes.
openaire +2 more sources
Pharmacogenomics, the study of the association between genetics and drug response, is a rapidly growing field in human genetics. At a recent IBC Life Sciences conference in London, ‘SNPs and Pharmacogenomics,’ speakers emphasized the potential of pharmacogenomics to revolutionize traditional drug discovery and development processes.
openaire +2 more sources