Pharmacokinetic assessment of vancomycin in critically ill patients and nephrotoxicity prediction using individualized pharmacokinetic parameters [PDF]
Frontiers in Pharmacology, 2022 Introduction: Therapeutic drug monitoring (TDM) and pharmacokinetic assessments of vancomycin would be essential to avoid vancomycin-associated nephrotoxicity and obtain optimal therapeutic and clinical responses.
Parisa Ghasemiyeh +11 more
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Pharmacokinetic Parameters of Oral Pegylated IFN-λ1. [PDF]
Bull Exp Biol Med, 2022 We studied the pharmacokinetics of a pegylated IFN-λ1 (PEG IFN-λ1) after its oral administration to rats in different therapeutic doses. The hypothesis on linear pharmacokinetics of PEG IFN-λ1 within the dose range of 2.6-7.8 μg/kg was confirmed, high for protein molecules bioavailability from 17.5 to 21%, the absence of intravascular deposition, and ...
Sherstoboev EY +4 more
europepmc +3 more sources
Serum Predose Metabolic Profiling for Prediction of Rosuvastatin Pharmacokinetic Parameters in Healthy Volunteers [PDF]
Frontiers in Pharmacology, 2021 Rosuvastatin is a well-known lipid-lowering agent generally used for hypercholesterolemia treatment and coronary artery disease prevention. There is a substantial inter-individual variability in the absorption of statins usually caused by genetic ...
Anne Michelli Reis Silveira +6 more
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Investigation of Pharmacokinetic Parameters of Trelagliptin in Egyptian Volunteers Using Sensitive LC-MS/MS: A Comparative Study with a Japanese Population [PDF]
Journal of Analytical Methods in Chemistry, 2021 Trelagliptin (TLN) is a novel once-weekly antidiabetic drug that enhanced the patient compliance in type 2 diabetes. TLN analysis and bioanalysis literature review showed many methods for TLN assay either in dosage form or as biological fluids ...
Shereen Mowaka +3 more
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Журнал органічної та фармацевтичної хімії, 2020 Aim. To study pharmacokinetic parameters of the potential active pharmaceutical ingredient (API) morpholinium 2-((4-(2-methoxyphenyl)-5-(pyridin-4-yl)-4H-1,2,4-triazol-3-yl)thio)acetate in the blood plasma of rats when administered intraperitoneally ...
Borys O. Varynskyi
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Differentiation between primary central nervous system lymphomas and gliomas according to pharmacokinetic parameters derived from dynamic contrast-enhanced magnetic resonance imaging [PDF]
HeliyonPurpose: It is difficult to differentiate between primary central nervous system lymphoma and primary glioblastoma due to their similar MRI findings. This study aimed to assess whether pharmacokinetic parameters derived from dynamic contrast-enhanced MRI
Yu Zhang +4 more
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Recalling the Definition of Basic Pharmacokinetic Parameters to Avoid Potential Pitfalls. [PDF]
Eur J Drug Metab PharmacokinetWeiss M.
europepmc +3 more sources
Estimating drug-induced liver injury risk by in vitro molecular initiation response and pharmacokinetic parameters for during early drug development. [PDF]
Toxicol Res (Camb), 2023 Nukaga T +4 more
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Clinical Application Value of Pharmacokinetic Parameters of Vancomycin in Children Treated in the Pediatric Intensive Care Unit. [PDF]
Front Pediatr, 2022 Zhou B +7 more
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Conceptos y aplicaciones de los parámetros farmacocinéticos: Una guía para el salón de clases. | [Concepts and applications of pharmacokinetic parameters: A guide for the classroom] [PDF]
Journal of Pharmacy & Pharmacognosy Research, 2023 Context: Pharmacokinetic studies play a fundamental role in making informed decisions during the drug development stage and fulfilling regulatory agencies’ requirements for drug approval.
Jorge Duconge-Soler +2 more
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