Results 121 to 130 of about 222,667 (349)

Onset of Action and Pharmacokinetic Parameters of Azelastine Hydrochloride in Azelastine Nasal Spray and in a Combination Nasal Spray with Fluticasone Propionate [PDF]

, 2009
R. Berkowitz, Susan Braker, L. Fredane, Harry Sacks   +3 more
openalex   +1 more source

Ultrasound‐Triggered Nanobubbles for Endothelial‐Targeted Drug Delivery in the Detection and Treatment of Doxorubicin‐Induced Cardiotoxicity

Advanced Healthcare Materials, EarlyView.
The DA/VTP‐NBs selectively recognized cardiac ECs damaged by DIC and achieved cell‐level targeted imaging. Then US‐triggered controlled release successfully enabled the release of DAPA within the DA/VTP‐NBs at the site of injury. This precise on‐demand drug release approach amplifies a series of localized therapeutic effects through the mtDNA‐mediated ...
Jun Zhang, Yi Ling, Xin Li, Deng Liu, Li Dong, Xuemei Chen, Yingxin Sun, Yongning Shang, Yanli Guo   +8 more
wiley   +1 more source

Computational Study on Potentially Active Antibacterial Compounds in Secondary Metabolites of Extremophilic Microorganisms

ChemistryOpen
The density functional theory (DFT) method ωB97XD/6‐311+G(2d, p) was employed to perform systematic theoretical calculations and comparative analyses on the geometric structures, spectroscopic properties, frontier molecular orbitals, and molecular ...
Dilong Li, Yanni Wang, Yinhuan Huang, Hui Zhou, Xiaoyun Xia, Wei Huang, Chaojie Wang   +6 more
doaj   +1 more source

Respiratory Organ‐on‐a‐Chip for Disease Modeling: From Architecture to Functional Integration

Advanced Healthcare Materials, EarlyView.
Respiratory organ‐on‐a‐chip (ROC) models capture key mechanical and cellular cues of the human respiratory system, enabling quantitative dissection of disease mechanisms. This review links ROC architectures to disease modeling, functional integration, and commercialization, and proposes a decision framework that aligns model complexity with mechanistic
Jinzhuo Hu, Yongjie Tang, Sidi Liu, Tao Xu, Qian Liu   +4 more
wiley   +1 more source

An Integrated Transfer Learning and Multitask Learning Approach for Pharmacokinetic Parameter Prediction [PDF]

, 2018
Zhuyifan Ye, Yilong Yang, Xiaoshan Li, Dongsheng Cao, Defang Ouyang   +4 more
openalex   +1 more source

A Physiological Microfluidic Blood–Brain‐Barrier Model for In Vitro Study of Nanoparticle Trafficking and Accumulation

Advanced Healthcare Materials, EarlyView.
A human microfluidic blood‐brain barrier (mBBB) model enables spatially resolved comparison of nanoparticle trafficking. Extracellular vesicles (EVs), liposomes, and nanoplastics exhibit distinct transport and disruption behaviors, revealing that membrane composition and uptake pathways govern BBB interaction.
Bryan B. Nguyen, Neona M. Lowe, Sophia Kellogg, Kuan‐Wei Huang, Hannah O'Toole, Elizabeth J. Hale, Venktesh S. Shirure, Bhupinder S. Shergill, Steven C. George, Randy P. Carney   +9 more
wiley   +1 more source

Opinion: Gavage Administration of MXene as a Route‐Specific Alternative to Intravenous Injection into the Bloodstream of Laboratory Animals for Reducing Systemic Nanotoxicity Risks in Immunosuppression and Post‐Transplantation Models with Bile Acid Modification

Advanced Healthcare Materials, EarlyView.
Recent studies reported immunosuppressive properties of specific MXene nanomaterials. Their intravenous injection into the bloodstream of laboratory animals has been a common delivery method to suppress systemic inflammation and prevent transplant rejection.
Alireza Rafieerad, M. Akif Rahman, Ahmad Amiri   +2 more
wiley   +1 more source

A National Survey of Attitudes and Practices of Physicians Relating to Therapeutic Drug Monitoring and Clinical Pharmacokinetic Service: Strategies for Enhancing Patient’s Care in Saudi Arabia

International Journal of General Medicine, 2021
Ziyad Alrabiah,1,* Abdulrahman Alwhaibi,1,* Sary Alsanea,2 Fars K Alanazi,3 Hisham S Abou-Auda1 1Department of Clinical Pharmacy, College of Pharmacy, King Saud University, Riyadh, 11451, Saudi Arabia; 2Department of Pharmacology and Toxicology, College ...
Alrabiah Z, Alwhaibi A, Alsanea S, Alanazi FK, Abou-Auda HS   +4 more
doaj  

Determination of Pharmacokinetic Parameters of a Four-Armed, Guanidinium-Rich Structurally Nanoengineered Antimicrobial Peptide Polymer: A Research Protocol

, 2020
Matthew So, Rohan Aananth, Emmanuel Suntres   +2 more
openalex   +2 more sources

Pharmacokinetic Parameters and Estimated Milk Withdrawal Intervals for Domestic Goats (Capra Aegagrus Hircus) After Administration of Single and Multiple Intravenous and Subcutaneous Doses of Flunixin Meglumine [PDF]

, 2020
Joe S. Smith, Tara Marmulak, John A. Angelos, Zhoumeng Lin, Joan D. Rowe, Jan Carlson, Weilin L. Shelver, Elizabeth A. Lee, Lisa A. Tell   +8 more
openalex   +1 more source