Results 161 to 170 of about 222,667 (349)

Predictive Potential of BCS and Pharmacokinetic Parameters on Study Outcome: Analysis of 198 In Vivo Bioequivalence Studies. [PDF]

Eur J Drug Metab Pharmacokinet, 2023
Krajcar D, Grabnar I, Jereb R, Legen I, Opara J.   +4 more
europepmc   +1 more source

Pharmacokinetic analysis of tissue microcirculation using nested models: Multimodel inference and parameter identifiability

, 2009
Gunnar Brix, Stefan Zwick, Fabian Kießling, Jürgen Griebel   +3 more
openalex   +2 more sources

Paving the Way to Elucidate Hg's Role in Tumorigenesis

Advanced Science, EarlyView.
Tumorigenesis can result from diverse environmental carcinogens. Among them, mercury—a lifelong bioaccumulative Group 2B carcinogen—has tumorigenic potential that remains poorly understood due to confounding co‐exposures and limited organ‐specific data.
Shouying Li, Rong Zhong, Zhenyang Yu, Hualing Fu, Jin Chen, Jia Wei, Ningwei Zhao, Le Qu, Tiantian Li, Wenli Tang, Huan Zhong   +10 more
wiley   +1 more source

Discovery of SKP2‐Recruiting PROTACs for Target Protein Degradation

Advanced Science, EarlyView.
Based on the SKP2‐targeting ligand SL1, we designed non‐covalent PROTACs by linking it with the BRD4 inhibitor JQ1 and the AR antagonist AL through a linker. These PROTACs successfully induced the ubiquitination of BRD4 and AR, followed by proteasome‐mediated degradation.
Guanjun Dong, Aima Huang, Ziqing Zhao, Bikai Lai, Xin Pan, Huiyu Yang, Xiaohan Xu, Tianwei Wang, Fangchen Zhao, Zhimin Zhang, Yongbo Xue, Guanjun Deng, Wenbin Deng, Jianwei Chen   +13 more
wiley   +1 more source

Pharmacokinetic parameters and tissue distribution of magnetic Fe3O4 nanoparticles in mice

International Journal of Nanomedicine, 2010
Jun Wang1, Yue Chen1, Baoan Chen1, Jiahua Ding1, Guohua Xia1, Chong Gao1, Jian Cheng1, Nan Jin1, Ying Zhou1, Xiaomao Li1, Meng Tang2, Xue Mei Wang21Department of Hematology, Zhongda Hospital, Clinical Medical School, Southeast University, Nanjing, People&
Jun Wang, Yue Chen, Baoan Chen, et al
doaj  

Comparison of pharmacokinetic parameters of ranolazine between diabetic and non-diabetic rats. [PDF]

Iran J Basic Med Sci, 2022
Mashayekhi-Sardoo H, Kamali H, Mehri S, Sahebkar A, Imenshahidi M, Mohammadpour AH.   +5 more
europepmc   +1 more source

De Novo Design and Directed Evolution Refinement of Mirror‐Image Protein Binders Targeting Interleukin‐4

Advanced Science, EarlyView.
This study presents the de novo design and directed evolution of a mirror‐image D‐protein inhibitor targeting human interleukin‐4 (IL‐4). The engineered molecule exhibits nanomolar binding affinity for IL‐4 and effectively inhibits IL‐4–mediated signaling.
Liqing Xu, Yuxiang Ren, Tongyue Wang, Hongyong Li, Yue Yao, Lei Liu, Ke Sun, Peilong Lu   +7 more
wiley   +1 more source

Pharmacokinetic Parameter Test Code [PDF]

, 2020
openaire   +1 more source

Once versus divided daily dosing with delayed‐release mesalazine: a study of tissue drug concentrations and standard pharmacokinetic parameters [PDF]

, 2001
Fez Hussain, Ramzi Ajjan, Kapil Kapur, M. Moustafa, S A Riley   +4 more
openalex   +1 more source

Understanding and Overcoming Antibody‐Drug Conjugate Resistance: Biological Mechanisms and Emerging Analytical Frameworks in Breast Cancer

Advanced Science, EarlyView.
Antibody–drug conjugates (ADCs) transform breast cancer therapy, yet resistance limits their durability. Emerging evidence reveals that ADC failure is not solely tumor‐intrinsic but shaped by dynamic tumor–microenvironment interactions that alter drug delivery, processing, and response.
Minji Seo, Jangsoon Lee, Naoto T. Ueno
wiley   +1 more source