Results 11 to 20 of about 222,667 (349)
Asian Journal of Pharmaceutical Sciences, 2017 The present study was designed to investigate the influence of the pretreatment of piperazine ferulate on pharmacokinetic parameters of methotrexate in methotrexate-induced renal injury rats.
Huiyan Shi +9 more
doaj +2 more sources
Molecules, 2023 The present study aims to explore the anti-inflammatory potential activity of the hexane extract from branches (HEB) of Endlicheria paniculata (Lauraceae) and its main compound, methyldehydrodieugenol B, in the inflammatory response induced by a murine ...
Bruno Antonio Ferreira +9 more
doaj +1 more source
Pharmacokinetic Analysis of Gd-DTPA Enhancement in dynamic three-dimensional MRI of breast lesions [PDF]
, 1997 The purpose of this study was to demonstrate that dynamic MRI covering both breasts can provide sensitivity for tumor detection as well as specificity and sensitivity for differentiation of tumor malignancy.
de Vos, Rob A.I. +10 more
core +12 more sources
Pharmacokinetic studies of meloxicam after its intravenous administration in local goat (Capra hircus) of Assam [PDF]
Veterinary World, 2013 Aim: The aim of the present study was to determine the meloxicam concentrations in the plasma of goats at different time intervals after its administration by IV route and data were used to determine the different pharmacokinetic parameters and the ...
Dulal C. Roy +3 more
doaj +1 more source
Pharmacokinetic Parameters of Sisomicin [PDF]
Antimicrobial Agents and Chemotherapy, 1976 Sisomicin in doses of 1 mg/kg was administered intramuscularly to 10 healthy volunteers, and 1 week later the same volunteers received sisomicin at the same dose intravenously. A peak serum concentration of sisomicin of 3.08 μg/ml was obtained 1 h after intramuscular injection, and a peak serum concentration of 7.12 μg/ml was achieved 30 min after a 30-
B R, Meyers +3 more
openaire +2 more sources
In Silico Prediction of Toxicological and Pharmacokinetic Characteristics of Medicinal Compounds
Безопасность и риск фармакотерапии, 2023 Scientific relevance. Studies of the toxicological and pharmacokinetic properties of medicinal compounds are a crucial stage of preclinical research; unsatisfactory results may invalidate further drug development.
P. M. Vassiliev +4 more
doaj +1 more source
Journal of Applied Sciences and Environmental Management, 2023 Malaria is one of the major public health challenges in Nigeria. Treatment failure as a result of drug interaction is a major problem. A study of the effect of ascorbic acid on the antiplasmodial activity of artemether has been reported.
G. E. Aghayere, H. A. Okeri
doaj +1 more source
Antibiotics, 2022 In this study, the effectiveness of the combination therapy of 1,8-cineole with amoxicillin (AMX) and clavulanic acid (Clav) was investigated. For this, the pharmacokinetic behaviors of AMX in rabbits were studied after a single oral dose.
Ahmed Amin Akhmouch +6 more
doaj +1 more source
Pirbenicillin: Pharmacokinetic Parameters in Mice [PDF]
Antimicrobial Agents and Chemotherapy, 1976 The rapid intravenous administration to mice of pirbenicillin, carbenicillin, and ampicillin produced biexponential blood concentration-time curves when assessed by frequent blood samplings at short intervals. The pharmacokinetic behavior of pirbenicillin and the other penicillins was analyzed by the two-compartment open model.
A R, English, D, Girard, J A, Retsema
openaire +2 more sources
Безопасность и риск фармакотерапии, 2021 Nonsteroidal anti-inflammatory drugs, including acetylsalicylic acid, can have a dose-dependent nephrotoxic effect. The study of the pharmacokinetics of acetylsalicylic acid products will contribute to timely detection and correction of side effects ...
L. M. Krasnykh +5 more
doaj +1 more source