Results 231 to 240 of about 222,667 (349)

Xanthatin Targets CISD1 to Drive Ferroptosis and Mitophagy as a Dual Anticancer Strategy in Triple‐Negative Breast Cancer

Advanced Science, EarlyView.
Triple‐negative breast cancer has a poor prognosis. Xanthatin directly targets and degrades CISD1, triggering ferroptosis through iron dysregulation. The concurrently activated mitophagy synergistically amplifies ferroptotic cell death. Xanthatin also demonstrates potent in vivo anti‐tumor efficacy with minimal toxicity, highlighting its therapeutic ...
Qinwen Liu, Haojie Chen, Xiang Li, Jingxin Liu, Yiwen Li, Zhenyi Shi, Shenshen Guo, Qingfeng Du, Aiping Lu, Daogang Guan   +9 more
wiley   +1 more source

Named entity recognition of pharmacokinetic parameters in the scientific literature. [PDF]

Sci Rep
Gonzalez Hernandez F, Nguyen Q, Smith VC, Cordero JA, Ballester MR, Duran M, Solé A, Chotsiri P, Wattanakul T, Mundin G, Lilaonitkul W, Standing JF, Kloprogge F.   +12 more
europepmc   +1 more source

Trans-ε-Viniferin Encapsulation in Multi-Lamellar Liposomes: Consequences on Pharmacokinetic Parameters, Biodistribution and Glucuronide Formation in Rats. [PDF]

Nutrients, 2021
Beaumont P, Faure C, Courtois A, Jourdes M, Marchal A, Teissedre PL, Richard T, Atgié C, Krisa S.   +8 more
europepmc   +1 more source

Endothelial PDGF Signaling Dysregulation Impairs Testicular Interstitial Homeostasis in Diabetes

Advanced Science, EarlyView.
Testicular endothelial cells (TECs) function as central signaling hubs that coordinate interstitial homeostasis. Diabetes disrupts TEC‐derived PDGF signaling, silences the JUND‐MCL1 survival program in Leydig cells, and impairs peritubular function, leading to fibrosis and testosterone insufficiency.
Wenxiu Zhang, Kai Hong, Yanling Tang, Lina Cui, Xiaojian Lu, Jianxing Cheng, Yangyi Fang, Qiaoling Jiang, Ziyan Zhuang, Songzhan Gao, Hui Jiang, Qiang Liu, Jingtao Guo, Zhe Zhang, Xiaoyan Wang   +14 more
wiley   +1 more source

Correlation analysis of pharmacokinetic parameters of docetaxel AUC and adverse reactions in breast cancer patients. [PDF]

Front Pharmacol
Tang Y, Liu Y, Qin S, Huai C, Zhang J, Ding W, Fan J, Wang J, Zhang X.   +8 more
europepmc   +1 more source

Endothelial GPR68 Is Essential for Arteriogenesis and Represents a Therapeutic Target in a Model of Peripheral Artery Disease

Advanced Science, EarlyView.
Endothelial GPR68 is identified as a critical regulator of collateral artery growth in peripheral artery disease. Genetic and pharmacological evidence demonstrates that GPR68 integrates hemodynamic cues to drive monocyte recruitment and inflammatory remodeling, thereby promoting collateral arteriogenesis and tissue perfusion after ischemia ...
Yiyan Song, Senyi Peng, Zhilei Huang, Miao Yu, Mingyue Wu, Yuexin Zhu, Zeyi Zhou, Yongshan Liu, Yalin Zhang, Yu Huang, Zhongxing Wang, Fu‐Li Xiang, Jie Xu   +12 more
wiley   +1 more source

Analysis of Lipophilicity and Pharmacokinetic Parameters of Dipyridothiazine Dimers with Anticancer Potency. [PDF]

Pharmaceutics
Martula E, Morak-Młodawska B, Jeleń M, Okechukwu PN.   +3 more
europepmc   +1 more source

Plasma Pharmacokinetic Parameters of Dexamethasone Following Administration of a Dexamethasone Intracanalicular Insert in Healthy Adults. [PDF]

Clin Ophthalmol, 2021
Blizzard C, McLaurin EB, Driscoll A, Silva FQ, Vantipalli S, Metzinger JL, Goldstein MH.   +6 more
europepmc   +1 more source

<p>In vitro activity and pharmacodynamic/pharmacokinetic parameters of clarithromycin and azithromycin: why they matter in the treatment of respiratory tract infections</p>

, 2019
Ross Davidson
openalex   +1 more source

Within‐ and between‐subject variations in pharmacokinetic parameters of ethanol by analysis of breath, venous blood and urine [PDF]

, 2000
Åke Norberg, Johan Gabrielsson, Alan Wayne Jones, Robert G. Hahn   +3 more
openalex   +1 more source