Results 241 to 250 of about 222,667 (349)

PVNCRF Neurons Regulate Migraine‐Like Allodynia by Activating CRFR2 on Spinal Trigeminal Caudalis Glutamatergic Neurons

Advanced Science, EarlyView.
Paraventricular CRF neurons in the hypothalamus project to glutamatergic neurons of the spinal trigeminal caudal nucleus, enhancing neuronal activation and CRFR2 signaling. This pathway increases CRF release and excitatory drive, promoting central sensitization and migraine‐related behaviors. Targeting the PVN–SP5C circuit provides a potential strategy
Jiang Bian, Xiao‐Long Wang, Li Yin, Wei Wei, Xue Li, Yao Ge, Zhao‐Xia Xiang, Na Tian, Li‐Juan Chen, Ming‐Wei Ma, Xia Zhang, Xu Jing, Mei‐Yun Wang, Xu‐Feng Xu   +13 more
wiley   +1 more source

Assessment of basic pharmacokinetic parameters of dapagliflozin in TTS formulations in male minipigs. [PDF]

Sci Rep
Paweł B, Balwierz R, Mieszko D, Mikołaj K, Micewicz E, Dawid B, Pogorzelec Ł.   +6 more
europepmc   +1 more source

Global Sensitivity Analysis of a Physiologically-based Pharmacokinetic (PBPK) Model of Bromochloromethane [PDF]

, 2020
Sawyer, Colton
core   +1 more source

Development and Structural Characterization of UTE‐156, a Covalent Inhibitor of the VCP/p97 AAA+ ATPase

Advanced Science, EarlyView.
The AAA+ ATPase Valosin‐containing protein (VCP/p97) regulates protein homeostasis by unfolding ubiquitinated substrates. Here, we describe UTE‐156, a novel irreversible covalent inhibitor that modifies Cys522 in the D2 ATPase motor domain. Although its pharmacochemical limitations preclude immediate therapeutic use, UTE‐156 serves as a valuable ...
Daniela Tamayo‐Jaramillo, Subramanya Hegde, Xuan Jia, Kimberly Coffman, Hariprasad Vankayalapati, David Bearss, Kevin B. Jones, Alex W. Stark, Peter S. Shen   +8 more
wiley   +1 more source

Assessment of Bacteriophage Pharmacokinetic Parameters After Intra-Articular Delivery in a Rat Prosthetic Joint Infection Model. [PDF]

Viruses
Young J, Shariyate MJ, Misra P, Laiwala S, Laiwala S, Nazarian A, Rodriguez EK.   +6 more
europepmc   +1 more source

Profiling Localized Immunomodulation and Drug Biodistribution within a Subcutaneous Vascularized Niche for Cell Transplantation

Advanced Science, EarlyView.
We studied how five common immunosuppressants behave when delivered directly to a transplant site instead of systemically. Using a vascularized implant for islet transplantation, we show that local delivery protects grafts, limits drug spread to the rest of the body, and produces distinct immune signatures.
Jocelyn Nikita Campa‐Carranza, Simone Capuani, Melissa A. Willman, Alexander Rabassa, Ashley L. Joubert, Tommaso Bo, Letizia Franco, Marzia Conte, Ana L. Anaya‐García, Gabrielle E. Rome, Rim Ouni, Henry J. Seaborne, Camden A. Caffey, Dora M. Berman, Junjun Zheng, Jesus Paez‐Mayorga, Corrine Ying Xuan Chua, Shu Hsia Chen, Norma S. Kenyon, Alessandro Grattoni   +19 more
wiley   +1 more source

The Role of ABCB1, ABCG2, and SLC Transporters in Pharmacokinetic Parameters of Selected Drugs and Their Involvement in Drug-Drug Interactions. [PDF]

Membranes (Basel)
Kiełbowski K, Król M, Bakinowska E, Pawlik A.   +3 more
europepmc   +1 more source

Pharmacokinetic Parameters Supplemental Qualifiers Dataset [PDF]

, 2020
openaire   +1 more source

Development and optimization of carvedilol orodispersible tablets: enhancement of pharmacokinetic parameters in rabbits

, 2015
Khalid M. El‐Say, Yazeed Aljimaee, Abdel-Rahim El-Helw, Osama A. A. Ahmed   +3 more
openalex   +2 more sources

Correction: Steady-state mycophenolate mofetil pharmacokinetic parameters enable prediction of systemic lupus erythematosus clinical flares: an observational cohort study [PDF]

, 2011
Sarah Djabarouti, Dominique Breilh, P. Duffau, Estibaliz Lazaro, C. Greib, O. Caubet, Marie‐Claude Saux, Jean‐Luc Pellegrin, Jean‐François Viallard   +8 more
openalex   +1 more source