Results 251 to 260 of about 222,667 (349)

Oil‐Coated Nanoplastics Induce Rapid Membrane Disruption and Severe Intestinal Injury

Advanced Science, EarlyView.
Oil‐rich food contact dramatically amplifies MNP release from plastic takeout containers, producing oil‐coated nanoplastics with altered surface properties and rapid membrane‐disruptive effects. These particles cause severe intestinal barrier damage and immune dysfunction in mice, and risk modeling suggests that long‐term gastrointestinal burdens may ...
Ruwen Xie, Gulimire Yilihan, Qiong Chen, Dachuan Lin, Zhen Liu, Mengyi Yuan, Yujia Wang, Haoteng Xu, Weishang Zhou, Wanxin Gong, Yueer Li, Chen Peng, Tong Yang, Peng Gao, Qing Liu, Xin‐Hua Feng, Mu Xiao, Chao Jiang   +17 more
wiley   +1 more source

Performance of recurrent neural networks with Monte Carlo dropout for predicting pharmacokinetic parameters from dynamic contrast-enhanced magnetic resonance imaging data. [PDF]

J Appl Clin Med Phys
Murase K, Nakamoto A, Tomiyama N.
europepmc   +1 more source

Pharmacokinetic Parameter Reason Not Done [PDF]

, 2020
openaire   +1 more source

Ammonia Detoxification Inhibits Liver Metastasis by Reshaping Hepatic Microenvironment

Advanced Science, EarlyView.
Liver metastasis diverts aspartate into hyperactive pyrimidine synthesis, disrupting urea cycling and causing pathogenic ammonia accumulation. Ammonia dually reprograms the microenvironment by: (1) activating hepatic stellate cells (HSCs) into pro‐fibrotic metastasis‐associated fibroblasts (MAFs), and (2) suppressing anti‐tumor monocytes/macrophages ...
Sumin Sun, Haili Hu, Long Chen, Yuan Gao, Peng Sun, Liming Chen   +5 more
wiley   +1 more source

Trends of in vitro pharmacological potency and in vivo pharmacokinetics parameters of modern drugs: Can the therapeutic/subtherapeutic dose be estimated from in vitro K_i and pharmacokinetic parameters? [PDF]

Clin Transl Sci
Tsuchitani T, Kato M, Tomaru A, Aoki Y, Sugiyama Y.   +4 more
europepmc   +1 more source

TWO-COMPARTMENT MODEL IN PHARMACOKINETICS FROM THE VIEWPOINT OF THE ALMOST-ONE PARAMETER HYPOTHESIS

, 1987
Motosaburô Masuyama
openalex   +2 more sources

Hepatocyte BDNF Acts as a Novel Immune Checkpoint to Restrain TLR4‐Mediated Acute Hepatitis

Advanced Science, EarlyView.
This study identifies hepatocyte‐derived BDNF as an endogenous TLR4 antagonist that alleviates acute hepatitis. BDNF is downregulated in hepatocytes via REST‐mediated transcriptional repression during ALI/ALF. Mechanistically, BDNF binds to TLR4 on macrophages to suppress inflammation.
Weiwei Zhu, Yaqian Cui, Yongqiang Zhou, Yihui Zheng, Lijiang Huang, Leiming Jin, Qianhui Zhang, Pan Chen, Mengsha Lin, Jiaxi Ye, Yongqiang Xiong, Joo Young Huh, Xiang Hu, Xiaokun Li, Wu Luo, Guang Liang   +15 more
wiley   +1 more source

A Meta-Analysis Methodology in Stan to Estimate Population Pharmacokinetic Parameters from Multiple Aggregate Concentration-Time Datasets: Application to Gevokizumab mPBPK Model. [PDF]

Pharmaceutics
Karakitsios E, Dokoumetzidis A.
europepmc   +1 more source

Novel Vascular‐Adaptive Liquid Metal Microspheres Enable Visualized Arterial Embolization Therapy

Advanced Science, EarlyView.
We present drug‐loaded liquid metal microspheres (X‐MEN) as a novel agent for image‐guided arterial embolization. With inherent radiopacity and superior deformability, X‐MEN enables real‐time monitoring and conforms tightly to irregular vessels. This approach ensures precise, long‐lasting embolization without recanalization, addressing critical ...
Chenyu Shen, Junge Chen, Gang Zhang, Zhusheng Liu, Yichen Wan, Lei Lei, Weiyan Ren, Yanyu Zhao, Bozhang Xia, Zhiqiang Yi, Jinjin Wang, Jingwang Gao, Gen Mu, Xing‐Jie Liang, Zhijun Wang   +14 more
wiley   +1 more source

Evaluation of Ornidazole Tablets Bioequivalence in Chinese Healthy Participants Under Fasted and Fed Conditions Using Pharmacokinetic Parameters. [PDF]

Drugs R D
Wang Y, He Y, Li W, Li H, Tang L, Dai X, Pei Y, Gao L.   +7 more
europepmc   +1 more source