Results 21 to 30 of about 222,667 (349)

Studying the pharmacokinetics of biotechnological medicinal products on the example of monoclonal antibodies

open access: yesБиопрепараты: Профилактика, диагностика, лечение, 2023
Therapeutic monoclonal antibodies (mAbs), which are developed to treat many pathologies, including cancer, autoimmune and infectious diseases, are one of the fastest growing classes of medicinal products.
V. V. Smirnov   +4 more
doaj   +1 more source

An annotated corpus with nanomedicine and pharmacokinetic parameters [PDF]

open access: yes, 2017
A vast amount of data on nanomedicines is being generated and published, and natural language processing (NLP) approaches can automate the extraction of unstructured text-based data. Annotated corpora are a key resource for NLP and information extraction
Jimenez, Ivan   +2 more
core   +2 more sources

DOXYCYCLINE INTAKE AND DISTRIBUTION IN THE BODY OF BROILER CHICKENS WITH ORNITHOBACTERIOSIS

open access: yesUkrainian Journal of Veterinary Sciences, 2021
The clinical efficiency of the antibiotic is determined by its distribution in organs and tissues, the ability to penetrate the physiological and pathological barriers of the body. The article presents the results from a study of the intake, distribution,
V. B. Dukhnitskyi   +3 more
doaj   +1 more source

Pharmacokinetics of Toxin-Derived Peptide Drugs

open access: yesToxins, 2018
Toxins and venoms produced by different organisms contain peptides that have evolved to have highly selective and potent pharmacological effects on specific targets for protection and predation.
David Stepensky
doaj   +1 more source

Hybrid Dissolving Microneedle-Mediated Delivery of Ibuprofen: Solubilization, Fabrication, and Characterization

open access: yesPharmaceuticals, 2023
Microneedles have recently emerged as a promising platform for delivering therapeutic agents by disrupting the skin, resulting in improved and high drug delivery via this route.
Talaya Hidayatullah   +8 more
doaj   +1 more source

Population Pharmacokinetics and Pharmacodynamics of Extended-Infusion Piperacillin and Tazobactam in Critically Ill Children [PDF]

open access: yes, 2015
The study objective was to evaluate the population pharmacokinetics and pharmacodynamics of extended-infusion piperacillintazobactam in children hospitalized in an intensive care unit.
Buenger, Lauren E.   +7 more
core   +2 more sources

The study of the permeability of the blood-brain barrier for new neurotropic peptide drugs

open access: yesФармакокинетика и Фармакодинамика, 2019
The paper presents the results of studies of penetration through the hemato-encephalic barrier (BBB) of rats of three new peptide drugs -modified analogues of endogenous neuropeptides and their active metabolites created in the research Zakusov institute
V. P. Zherdev   +2 more
doaj   +1 more source

Pharmacokinetics of Carboplatin in Combination with Low-Dose Cyclophosphamide in Female Dogs with Mammary Carcinoma

open access: yesAnimals, 2022
This prospective study aimed to evaluate the effect of metronomic cyclophosphamide on carboplatin’s tolerability, efficacy, and pharmacokinetics in dogs with mammary carcinoma.
Marília Carneiro Machado   +9 more
doaj   +1 more source

Medication Complications in Extracorporeal Membrane Oxygenation. [PDF]

open access: yes, 2017
The need for extracorporeal membrane oxygenation (ECMO) therapy is a marker of disease severity for which multiple medications are required. The therapy causes physiologic changes that impact drug pharmacokinetics.
Aebi   +99 more
core   +2 more sources

Relationship Between Pharmacokinetic Parameters and Imaging Duration in Dynamic 11C-Acetate Cardiac PET/CT

open access: yesXiehe Yixue Zazhi, 2023
Objective  To evaluate the effect of imaging time on the pharmacokinetic parameters calculation of dynamic 11C-acetate cardiac positron emission tomography (PET) scan and to investigate the feasibility of shortening the imaging time in clinical practice. 
GONG Tan   +4 more
doaj   +1 more source

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