Results 301 to 310 of about 222,667 (349)

Regarding Dose-Independent Pharmacokinetic Parameters in Nonlinear Pharmacokinetics

Journal of Pharmaceutical Sciences, 1991
There seems to be an increasing trend in pharmacokinetics and pharmacodynamics to deal with parameters that require minimal kinetic structure assumptions. Such parameters, which often inappropriately are called "model-independent parameters", seem more rational to work with than parameters that depend on the particular structure of specific models. The
P, Veng-Pedersen, H Y, Cheng, W J, Jusko
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Parameter optimisation in clinical pharmacokinetics

Computer Programs in Biomedicine, 1982
This paper describes a package of computer programs designed to be used in Clinical Pharmacokinetics or Clinical Chemistry Laboratories to assist in the interpretation of plasma drug concentration measurements. A simple pharmacokinetic model is utilised, and values of the necessary parameters for the general population determined using standard ...
A W, Kelman, B, Whiting, S M, Bryson
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Prediction of Pharmacokinetic Parameters

2012
In silico tools specifically developed for prediction of pharmacokinetic parameters are of particular interest to pharmaceutical industry because of the high potential of discarding inappropriate molecules during an early stage of drug development itself with consequent saving of vital resources and valuable time.
A K, Madan, Harish, Dureja
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Bayesian Parameter Estimation and Population Pharmacokinetics

Clinical Pharmacokinetics, 1992
The widespread application of Bayesian parameter estimation in the area of therapeutic drug monitoring (TDM) has prompted the need for well conducted population studies to obtain relevant prior pharmacokinetic parameter estimates. In many cases the population has consisted of a relatively small number of subjects. This may be unavoidable for drugs used
A H, Thomson, B, Whiting
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Allometric analysis of doxycycline pharmacokinetic parameters

Journal of Veterinary Pharmacology and Therapeutics, 1990
Riond, J.‐L. & Riviere, J.E. Allometric analysis of doxycycline pharmacokinetic parameters.J. vet. Pharmacol. Therap.13, 404–407.Doxycycline serum concentration‐time profiles and elimination half‐lives in several species were evaluated by allometric techniques. Doxycycline elimination half‐life increased with body weight.
J L, Riond, J E, Riviere
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Bayesian estimation of doxorubicin pharmacokinetic parameters

Cancer Chemotherapy and Pharmacology, 1991
Doxorubicin was given by brief i.v. infusion (doses ranging from 25 to 72 mg/m2) to 28 patients for 2-7 successive courses of chemotherapy (68 courses studied in all). A Bayesian approach was developed to determine the individual pharmacokinetic parameters of doxorubicin.
F, Bressolle, P, Ray, J M, Jacquet, J, Brès, M, Galtier, D, Donadio, J, Jourdan, J F, Rossi   +7 more
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Pharmacokinetic parameters of mescaline in rabbits

European Journal of Drug Metabolism and Pharmacokinetics, 1982
By means of a highly specific and sensitive mass fragmentographic method mescaline was measured in rabbit plasma samples, taken at various points after an i.v. injection. The pharmacokinetic behaviour conformed to the two-compartment open model. Half-life times of alpha and beta phases, velocity constants and steady-state distribution volumes of four ...
C, Van Peteghem, A, Heyndrickx, W, Van Zele   +2 more
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Pharmacokinetic parameters of bevantolol in volunteers

European Journal of Clinical Pharmacology, 1986
The pharmacokinetics of the new beta-adrenoceptor blocking drug bevantolol and some aspects of its beta-blocking effect have been studied in healthy volunteers. Bevantolol had a short serum half-life (86 +/- 33 min) and high systemic availability after oral administration.
P, Vermeij, P, van Brummelen
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Factor VIIa inhibitors: Improved pharmacokinetic parameters

Bioorganic & Medicinal Chemistry Letters, 2006
Efforts to improve the potency and pharmacokinetic properties of small molecule factor VIIa inhibitors are described. Small structural modifications to existing leads allow the modulation of half-life and clearance, potentially making these compounds suitable candidates for drug development.
Aleksandr, Kolesnikov, Roopa, Rai, Wendy B, Young, Joyce, Mordenti, Liang, Liu, Steven, Torkelson, William D, Shrader, Ellen M, Leahy, Huiyong, Hu, Erik, Gjerstad, James, Janc, Bradley A, Katz, Paul A, Sprengeler   +12 more
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Pharmacokinetics of etoposide: correlation of pharmacokinetic parameters with clinical conditions

Cancer Chemotherapy and Pharmacology, 1993
The pharmacokinetic parameters of etoposide were established in 35 patients receiving the drug parenterally within the framework of different polychemotherapy protocols. A total of 62 data for 24-h kinetics were analysed. After sample extraction and high-performance liquid chromatography (HPLC) or thin-layer chromatographic (TLC) separation, etoposide ...
K H, Pflüger, M, Hahn, J B, Holz, L, Schmidt, P, Köhl, H W, Fritsch, H, Jungclas, K, Havemann   +7 more
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