Results 311 to 320 of about 222,667 (349)

Pharmacokinetic parameters of14C oxithiopurinol in rat

European Journal of Drug Metabolism and Pharmacokinetics, 1979
The study with labelled compound has shown that in rat, as in man, thiopurinol is primarily and rapidly converted into oxithiopurinol. More than 80% of the radioactivity of plasma was identified as oxithiopurinol less than 10 minutes after intravenous or oral administration.
C, Pasquier, C, Auscher
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Pharmacokinetic parameters obtained with racemates

Trends in Pharmacological Sciences, 1986
Abstract The extensive therapeutic use of racemates of chiral drugs, wherein one enantiomer contains most, if not all of the biological activity, raises questions about the usefulness of pharmacokinetic parameters based on measurements of racemic drug.
Thomas Walle, U.Kristina Walle
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Variability of pharmacokinetic parameters for contraceptive steroids

Journal of Steroid Biochemistry, 1983
Studies of the pharmacokinetics of three contraceptive steroids, ethynyloestradiol, norethisterone and norethisterone oenanthate, in large groups of women are reviewed. Extremely wide variations were observed between women in the various calculated pharmacokinetic parameters.
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Correlation of Aminoglycoside and Vancomycin Pharmacokinetic Parameters

Annals of Pharmacotherapy, 1993
OBJECTIVE: To investigate a correlation between the elimination rate constants (Ke) of aminoglycosides (AG) and vancomycin; to investigate the correlation between actual Ke and creatinine clearance (Clcr) for AG versus vancomycin; to investigate the calculated versus actual Ke for AG and vancomycin; and to investigate a correlation between volumes of ...
T M, Wragge, B E, Cooper
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Pharmacokinetic Parameters Relevant to Recovery from Opioids

Anesthesiology, 1994
Several recent studies have suggested that the terminal half-lives of many drugs do not predict the rate of washout of drug after the relatively short durations of infusions used in anesthesia. Many anesthetic drugs fit a three-compartment mamillary model, with three volumes of distribution (central [V1] and peripheral [V2 and V3]) and three clearances
E J, Youngs, S L, Shafer
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Pharmacometabolomics applied to zonisamide pharmacokinetic parameter prediction

Metabolomics, 2018
Zonisamide is a new-generation anticonvulsant antiepileptic drug metabolized primarily in the liver, with subsequent elimination via the renal route.Our objective was to evaluate the utility of pharmacometabolomics in the detection of zonisamide metabolites that could be related to its disposition and therefore, to its efficacy and toxicity.This study ...
J. C. Martínez-Ávila, A. García Bartolomé, I. García, I. Dapía, Hoi Y. Tong, L. Díaz, P. Guerra, J. Frías, A. J. Carcás Sansuan, A. M. Borobia   +9 more
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Pharmacokinetic parameters of bromperidol in Korean subjects

Human Psychopharmacology: Clinical and Experimental, 2006
AbstractWe have presented pharmacokinetic parameters of bromperidol (BP) in 14 healthy Korean subjects. Additionally, we have investigated the effects of dose and genetic polymorphisms on BP metabolism and on extrapyramidal symptoms (EPS). The Tmax (3.9 ± 0.9 h), clearance (1.37 ± 0.52 ml/h/kg), and t1/2 (20.4 ± 3.7 h) obtained in our study are ...
Soo-Youn, Lee, Yoon Gyoon, Kim, Hyung-Gun, Kim, Jong-Won, Kim   +3 more
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Flucytosine: Correlation between Toxicity and Pharmacokinetic Parameters

Chemotherapy, 2000
Flucytosine (5-fluorocytosine, 5-FC) is a systemic antimycotic drug the major toxicities of which are bone marrow depression and hepatotoxicity. The purpose of this observational and retrospective study was to assess a possible relationship between toxicity and 5-FC pharmacokinetics within a group of 53 intensive care unit patients.
A, Vermes, H, van Der Sijs, H J, Guchelaar   +2 more
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Interspecies Extrapolation of Physiological Pharmacokinetic Parameter Distributions

Risk Analysis, 1996
Three methods (multiplicative, additive, and allometric) were developed to extrapolate physiological model parameter distributions across species, specifically from rats to humans. In the multiplicative approach, the rat model parameters are multiplied by the ratio of the mean values between humans and rats.
K H, Watanabe, F Y, Bois
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Estimation of pharmacokinetic model parameters.

Proceedings. Symposium on Computer Applications in Medical Care, 1996
This paper addresses the problem of estimating the depth of anesthesia in clinical practice where many drugs are used in combination. The aim of the project is to use pharmacokinetically-derived data to predict episodes of light anesthesia. The weighted linear combination of anesthetic drug concentrations was computed using a stochastic pharmacokinetic
A, Timcenko, D L, Reich, G, Trunfio
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