Results 71 to 80 of about 222,667 (349)

The role of studies of interspecies differences pharmacokinetics in the creation of new peptide drugs

open access: yesФармакокинетика и Фармакодинамика, 2018
Resume. The paper presents literature data about the interspecific differences of the pharmacokinetics of peptide drugs and the results of our own studies on the inter-specific features of the pharmacokinetics of the 3 modified analogues of endogenous ...
V. P. Zherdev   +5 more
doaj   +1 more source

Bridging pharmacokinetics between herbivorous mammal species by allometric analysis: A case study of ceftiofur [PDF]

open access: yesActa Veterinaria, 2012
The objective of the present study was to analyze the relationship between pharmacokinetic parameters of cephalosporine antibiotic ceftiofur in mammals and the respective body weight (W), using reported data from different authors.
Haritova Aneliya, Lashev L.
doaj   +1 more source

Eletriptan in the management of acute migraine. An update on the evidence for efficacy, safety, and consistent response [PDF]

open access: yes, 2016
Migraine is a multifactorial, neurological and disabling disorder, also characterized by several autonomic symptoms. Triptans, selective serotonin 5-HT1B/1D agonists, are the first-line treatment option for moderate-to-severe headache attacks.
Capi, Matilde   +6 more
core   +1 more source

Some Pharmacokinetic Parameters of Oxfendazole in Sheep

open access: yesVeterinary Research Communications, 1997
Soraci, A.L., Mestorino, N. and Errecalde, J.O., 1997. Some pharmacokinetic parameters of oxfendazole in sheep.
Soraci, Alejandro Luis   +2 more
openaire   +3 more sources

RNA‐Micelles as Self‐Assembling Structures for Efficient Co‐Delivery of Synergistic siRNA and Nucleoside Analogues to Treat CRC Lung Metastasis

open access: yesAdvanced Functional Materials, EarlyView.
Two kinds of self‐assembled RNA micelles were used to co‐deliver synergistic siRNA and nucleoside analogues for the treatment of colorectal cancer lung metastases. Near‐complete elimination of lung cancer metastases was confirmed in an orthotopic lung metastasis model constructed using human colorectal cancer lung metastases patient surgical samples to
Kai Jin   +4 more
wiley   +1 more source

Novel curcumin-loaded human serum albumin nanoparticles surface functionalized with folate: characterization and in vitro/vivo evaluation

open access: yesDrug Design, Development and Therapy, 2016
Zhiwang Song,1,* Yonglin Lu,1,* Xia Zhang,1,* Haiping Wang,2 Junyi Han,3 Chunyan Dong1 1Breast Cancer Center, 2Department of Pharmacy, 3Department of Gastrointestinal Surgery, Shanghai East Hospital, Tongji University, Shanghai, People’s Republic ...
Song Z   +5 more
doaj  

Mitigation of Rheumatic Arthritis in a Rat Model via Transdermal Delivery of Dapoxetine HCl Amalgamated as a Nanoplatform: In vitro and in vivo Assessment

open access: yesInternational Journal of Nanomedicine, 2020
Heba Farouk Salem,1 Mohamed Mahmoud Nafady,2 Rasha Mostafa Kharshoum,1 Omnia Ahmed Abd el-Ghafar,3 Hanan Osman Farouk2 1Pharmaceutics and Industrial Pharmacy Department, Faculty of Pharmacy, Beni- Suef University, Beni Suef, Egypt; 2Pharmaceutics and ...
Salem HF   +4 more
doaj  

Pharmacokinetics of Cephalexin after Intravenous and Single and Multiple Intramuscular Administration to Rabbit [PDF]

open access: yes, 2013
Cephalexin is a first generation cephalosporin widely used in rabbits. Its spectrum includes Pasteurella multocida and Staphylococcus aureus. These bacteria, together with Bordetella bronchiseptica, are the main cause of respiratory infections.
Albarellos, Gabriela Alejandra   +2 more
core   +2 more sources

VIVID: A qPCR‐Based Platform for Sensitive and Quantitative In Vivo Tracking of Extracellular Vesicles

open access: yesAdvanced Functional Materials, EarlyView.
This study introduces VIVID (Vesicle In Vivo Identification using DNA), a qPCR‐based platform that tracks PCR‐amplifiable DNA tags loaded in the EVs for accurate and quantifiable EV biodistribution in vivo. ABSTRACT Extracellular vesicles (EVs) represent promising carriers for nucleic acid therapeutics, offering advantages over synthetic nanoparticles ...
Oscar Boyadjian   +5 more
wiley   +1 more source

New high-performance liquid chromatography-dad method for analytical determination of arbutin and hydroquinone in rat plasma [PDF]

open access: yes, 2015
Natural substances present in herbal preparations should be carefully used because they can give toxic or therapeutic effects despite of their amount or the way of administration.
Altieri, I.   +5 more
core   +2 more sources

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