Results 151 to 160 of about 240,659 (269)

Membrane Fusion‐Mediated Cytosolic Delivery of Threose Nucleic Acids via Homotypic Nanoparticles Overcomes Drug Resistance in Triple‐Negative Breast Cancer

Advanced Science, EarlyView.
This study introduces a biomimetic “nanofusion” platform that integrates the biostability of threose nucleic acids (TNA) with homotypic cell‐membrane cloaking to combat drug‐resistant TNBC. By leveraging a non‐canonical membrane‐fusion pathway for direct cytosolic delivery, the platform bypasses endosomal sequestration. To achieve potent AKT2 silencing
Wei Zheng, Tristan Juin Han Chang, Xinchao Li, Zhongqi Zhou, Chung Tin, Kenward Vong, Pierre Karam, Pik Kwan Lo   +7 more
wiley   +1 more source

Insulin and Incretin Receptor Agonists Reciprocally Alter Their Blood-Brain Barrier Permeabilities. [PDF]

Int J Mol Sci
Fry A, Rose A, Weaver R, Hansen K, Blevins JE, Banks WA, Rhea EM.   +6 more
europepmc   +1 more source

Spatiotemporal Targeting Randle Cycle and Immune Checkpoint for Potent Antitumor Therapy

Advanced Science, EarlyView.
A glucose oxidase‐based nanogel (GOX‐NG) system using catechol‐functionalized alginate, exhibits enhanced tumor penetration, prolonged retention, and sustained glucose depletion in the tumor microenvironment. When combined with a fatty acid oxidation inhibitor, it implements dual metabolic suppression, thereby enhancing ROS‐induced immunogenic cell ...
Yuan Gao, Zijian Gong, Yixuan Fu, Jianan Zheng, Xiao Sang, Binglin Chen, Qinzhi Su, Weiping Gao, Fei Duan, Jinqi Wei, Xuliang Deng, Xinyu Liu   +11 more
wiley   +1 more source

Randomized, Placebo-Controlled, First-in-Human Study of the Safety, Tolerability, and Pharmacokinetics of Single and Repeat Oral Doses of Novel Antitubercular Drug Candidate, GSK2556286, in Healthy Adults. [PDF]

J Clin Pharmacol
Ilsley E, Banham-Hall E, Chaychenko T, Chinenyeze K, Maher-Edwards G, Muya C, Rolfe K, Sharma R, Tiberi S, Barros-Aguirre D.   +9 more
europepmc   +1 more source

Tumor Microenvironment‐Responsive Nanoreactor Induces Disulfidptosis in Pancreatic Cancer via Metabolic Interference and Redox Catalysis

Advanced Science, EarlyView.
Schematic illustration of a tumor microenvironment‐responsive nanoreactor for imaging‐guided induction of disulfidptosis in pancreatic cancer via metabolic interference and redox catalysis. (A) Stepwise fabrication of Pht@HMnO2‐HA, including MnO2 growth on a SiO2 template, template removal to form hollow mesoporous MnO2, Pht loading, and subsequent ...
Rui Fu, Qing Li, Guanzhong Zhao, Qingyan Gao, Huantong Chen, Khemayanto Hidayat, Jiaying Xu, Liqiang Qin, Chunhong Hu, Yu Chong, Su Hu   +10 more
wiley   +1 more source

Author Correction: Pharmacological markers of HIV prevention for oral pre-exposure prophylaxis in men who have sex with men. [PDF]

Nat Commun
Iannuzzi S, Müller M, Yu Y, Zhang L, Hendrix CW, Bies RR, von Kleist M.   +6 more
europepmc   +1 more source

Targeting Lipopolysaccharide Transport Induces Membrane Lipid Remodeling and Sensitizes Acinetobacter baumannii to Colistin Treatment

Advanced Science, EarlyView.
This study identifies C4 as a lead inhibitor of the Lpt system. Notably, C4 potentiates colistin activity by disrupting LPS transport and remodeling phospholipid homeostasis, revealing a functional interplay between the Lpt and Mla systems. These findings establish a mechanistic link between Lpt inhibition and membrane lipid remodeling, positioning Lpt–
Jianya Luo, Hetianzi Zhang, Jinju Cai, Shuang Zhou, Haijie Zhang, Zhiqiang Wang, Yuan Liu   +6 more
wiley   +1 more source

Pharmacokinetics and bio-distribution of differently functionalized Carbon nanotube in Zebrafish, Danio rerio. [PDF]

Discov Nano
Kumari K, Pathan MA, Surendran S, Varghese T, Poojary N, Singh AL, Kranthirekha M, Halim AFMF, Poinern GEJ, Fawcett D, Sharma R.   +10 more
europepmc   +1 more source

De Novo Designed Minibinders Targeting the GDF15–GFRAL Axis Reverse Cancer Cachexia and Restore Anti‐Tumor Immunity

Advanced Science, EarlyView.
Tumor‐derived GDF15 drives cancer cachexia and suppresses antitumor immunity. Here, de novo designed minibinders targeting the GDF15–GFRAL interface achieve picomolar affinity and potent pathway blockade. The minibinders alleviate cachexia, restore CD8+ T‐cell infiltration, enhance anti–PD‐1 responsiveness, and provide survival benefits across tumor ...
Haitao Wang, Tianzhen Hua, Meiling Wang, Bingbing Meng, Yue Zhang, Chengxu Jiang, Yunhe Gao, Hongqi Yang, Jian Bo   +8 more
wiley   +1 more source

Pharmacological markers of HIV prevention for oral pre-exposure prophylaxis in men who have sex with men. [PDF]

Nat Commun
Iannuzzi S, Müller M, Yu Y, Zhang L, Hendrix CW, Bies RR, von Kleist M.   +6 more
europepmc   +1 more source