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Pharmacokinetics of difloxacin in Sichuan Shelducks after single or multiple dosing. [PDF]
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Biochemical Pharmacology, 2014
Pharmacokinetics (PK) is the study of the time course of the absorption, distribution, metabolism and excretion (ADME) of a drug, compound or new chemical entity (NCE) after its administration to the body. Following a brief introduction as to why knowledge of the PK properties of an NCE is critical to its selection as a lead candidate in a drug ...
Jianghong, Fan, Inés A M, de Lannoy
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Pharmacokinetics (PK) is the study of the time course of the absorption, distribution, metabolism and excretion (ADME) of a drug, compound or new chemical entity (NCE) after its administration to the body. Following a brief introduction as to why knowledge of the PK properties of an NCE is critical to its selection as a lead candidate in a drug ...
Jianghong, Fan, Inés A M, de Lannoy
openaire +5 more sources
Pharmacokinetics of methotrexate
Clinical Pharmacology & Therapeutics, 1973Methotrexate (Mtx) is a competitive inhibitor of the enzymatic activity of dihydrofolate reductase, decreasing the reduction of folic acid to tetrahydrofolate and thereby the activity of thymi dilate kinase. The net effect is a decrease in biosynthesis of deoxyribonucleic acid (DNA) primarily, but also of ribonucleic acid (RNA) and protein. Whereas the
D H, Huffman +3 more
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Pharmacokinetics of Teicoplanin
Chemotherapy, 1988We investigated the pharmacokinetic properties of teicoplanin, after 200 mg i.v. and i.m. administration in 10 healthy male subjects by assuming a three-compartment open model with elimination from the central compartment. The mean peak plasma level was 7.16 micrograms/ml reached after 2.26 h.
RIPA, Sandro +3 more
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Journal of Pharmacokinetics and Pharmacodynamics, 2005
Pharmacokinetic (PK) models simplify biological complexity by dividing the body into interconnected compartments. The time course of the chemical's amount (or concentration) in each compartment is then expressed as a system of ordinary differential equations.
Brochot, Céline +2 more
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Pharmacokinetic (PK) models simplify biological complexity by dividing the body into interconnected compartments. The time course of the chemical's amount (or concentration) in each compartment is then expressed as a system of ordinary differential equations.
Brochot, Céline +2 more
openaire +5 more sources