Results 311 to 320 of about 599,269 (342)
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Pharmacokinetics of Nilvadipine
Journal of Cardiovascular Pharmacology, 1992Nilvadipine is absorbed rapidly and completely and its absolute bioavailability is about 14-19% because of its high first-pass metabolism. Maximum plasma levels and the extent of bioavailability increase proportionally with the dose. Nilvadipine is mainly excreted via the kidney as inactive metabolites. Slow tissue redistribution is probably the reason
H J Huber, A von Nieciecki, F Stanislaus
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An Overview on Pharmacokinetics and Pharmacokinetic Modeling
Asian Journal of Research in Pharmaceutical Science, 2020Pharmacokinetics is proposed to study the absorption, distribution, biotransformation and elimination of drugs in man and animals. A more careful description of the data can be obtained interpolating and extrapolating the drug concentrations with some mathematical functions.
T. H. Harish Kumar, Subhashis Debnath
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2009
This chapter discusses the concepts related to the use of drugs in vivo, specifically from the point of drug absorption, distribution throughout the body, metabolism by the hepatic (and other) systems and excretion (primarily through the renal system). The combination of these processes in vivo are considered as well as the various in vitro assays used
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This chapter discusses the concepts related to the use of drugs in vivo, specifically from the point of drug absorption, distribution throughout the body, metabolism by the hepatic (and other) systems and excretion (primarily through the renal system). The combination of these processes in vivo are considered as well as the various in vitro assays used
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Journal Of Pain & Palliative Care Pharmacotherapy, 2005
Methadone is a synthetic opioid that is effective for the relief of moderate-to-severe pain and for the treatment of opioid dependence. The pharmacokinetics of methadone differ from those of morphine in that methadone has a higher bioavailability, a much longer half-life, and is hepatically metabolized by cytochrome P450 enzymes.
Kristin L. Satterfield +2 more
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Methadone is a synthetic opioid that is effective for the relief of moderate-to-severe pain and for the treatment of opioid dependence. The pharmacokinetics of methadone differ from those of morphine in that methadone has a higher bioavailability, a much longer half-life, and is hepatically metabolized by cytochrome P450 enzymes.
Kristin L. Satterfield +2 more
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Diabetes Care, 1984
Where adjustments of diet, physical activity, and dosage of insulin are well known to diabetologists and diabetic patients, present-day knowledge of factors of importance to the pharmacokinetics of insulin is frequently ignored. The pharmacokinetics of insulin comprise the absorption process, the distribution including binding to circulating insulin ...
Binder, C +3 more
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Where adjustments of diet, physical activity, and dosage of insulin are well known to diabetologists and diabetic patients, present-day knowledge of factors of importance to the pharmacokinetics of insulin is frequently ignored. The pharmacokinetics of insulin comprise the absorption process, the distribution including binding to circulating insulin ...
Binder, C +3 more
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The pharmacokinetics of flavanones
Critical Reviews in Food Science and Nutrition, 2019The intake of flavanones, the predominant flavonoid in the Citrus genus in human diets is variable but considerable. It is thus unsurprising that they have attracted interest for their claimed positive effects on health. However, to substantiate any purported impact on health and decipher the underlying mechanism(s), knowledge of pharmacokinetics is ...
Iveta Najmanová +3 more
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Physiological pharmacokinetics
Bulletin of Mathematical Biology, 1986A discussion of the bases of physiological pharmacokinetics is followed by a brief review of the fundamental mass balance equations of the models. Some examples are outlined, together with a listing of published reviews which give many more references and detailed examples. Finally, some thoughts on future research directions are presented.
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Pharmacokinetics of Levetiracetam
Epilepsia, 2001Summary: Major considerations in the acceptance and impact of new antiepileptic drugs include their pharmacokinetics and their potential for interaction with other drugs. The pharmacokinetics of levetiracetam, a newly approved add‐on antiepileptic agent for partial‐onset seizures in adults, has been evaluated in 27 phase I and II studies.
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The Pharmacokinetics of Oxycodone
Journal Of Pain & Palliative Care Pharmacotherapy, 2005Oxycodone is among the most commonly used opioid analgesics for the relief of moderate-to-severe pain and is pharmacodynamically comparable to morphine. Oxycodone is available in the United States in oral dosage forms and controlled-release tablets. Studies have demonstrated marked interindividual variation in the pharmacokinetics of oxycodone.
Ralph A. Lugo, Steven E. Kern
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International Journal of Gynecology & Obstetrics, 1990
The main types of pharmacologic therapy used to treat the hormone deficiency of menopause are parenteral and oral administrations of estrogen. Parenteral administration results in predictable absorption without major intermediary metabolism, whereas all oral estrogens are subject to intestinal metabolism before entering the systemic circulation ...
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The main types of pharmacologic therapy used to treat the hormone deficiency of menopause are parenteral and oral administrations of estrogen. Parenteral administration results in predictable absorption without major intermediary metabolism, whereas all oral estrogens are subject to intestinal metabolism before entering the systemic circulation ...
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