Results 321 to 330 of about 599,269 (342)
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Pharmacokinetics in the elderly
European Journal of Clinical Pharmacology, 1975The pharmacokinetics of sulphamethizole, paracetamol and phenylbutazone were investigated and compared in young and geriatric subjects. The rate and extent of absorption of the drugs did not appear to be affected by increasing subject age. However, the mean half-lives for sulphamethizole and paracetamol were significantly increased in the geriatric ...
E. J. Triggs +3 more
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2008
Pharmacokinetics (PK) describes how the concentration of a dosed drug and its metabolites in body fluids and tissues changes with time. PK models the concentration-time profile using key parameters, such as volume of distribution (Vd), area under the curve (AUC), clearance (CL), half-life (t1/2), maximum concentration (Cmax), and bioavailability (F ...
Li Di, Edward H. Kerns
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Pharmacokinetics (PK) describes how the concentration of a dosed drug and its metabolites in body fluids and tissues changes with time. PK models the concentration-time profile using key parameters, such as volume of distribution (Vd), area under the curve (AUC), clearance (CL), half-life (t1/2), maximum concentration (Cmax), and bioavailability (F ...
Li Di, Edward H. Kerns
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Journal of Neurology, 2010
This paper reviews the clinically relevant determinants of levodopa peripheral pharmacokinetics and main observed changes in the levodopa concentration-effect relationship with Parkinson's disease (PD) progression. Available clinically practical strategies to optimise levodopa pharmacokinetics and pharmacodynamics are briefly discussed.
Manuela Contin, Paolo Martinelli
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This paper reviews the clinically relevant determinants of levodopa peripheral pharmacokinetics and main observed changes in the levodopa concentration-effect relationship with Parkinson's disease (PD) progression. Available clinically practical strategies to optimise levodopa pharmacokinetics and pharmacodynamics are briefly discussed.
Manuela Contin, Paolo Martinelli
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The American Journal of Medicine, 1985
The pharmacokinetics of glyburide can be described by a two-compartment open model. Terminal-phase descriptions are formulation-dependent and are complicated by apparent food-associated mobilization of drug from the stomach. Some researchers indicate a possible third (or deep) compartment, but this appears to be an artifact of a nonspecific drug assay.
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The pharmacokinetics of glyburide can be described by a two-compartment open model. Terminal-phase descriptions are formulation-dependent and are complicated by apparent food-associated mobilization of drug from the stomach. Some researchers indicate a possible third (or deep) compartment, but this appears to be an artifact of a nonspecific drug assay.
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Pharmacokinetics of Ceftriaxone
Hospital Practice, 1991Ceftriaxone fulfills many of the qualities of an ideal antibiotic: a prolonged elimination half-life, which results from a "restrictive" excretion pattern; saturable protein binding, which provides the theoretical basis for administering the total daily dose as a single bolus; and once-a-day dosing, which provides plasma and tissue concentrations that ...
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The Pharmacokinetization of Psychiatry
The Journal of Clinical Pharmacology, 1985The titration and monitoring of drug therapy using pharmacokinetic principles along with measurements of serum or plasma drug concentrations have become essential components of pharmacotherapy in many areas of clinical medicine, including the treatment of asthma, seizure disorders, certain infectious diseases, and cardiac arrhythmias.
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Seminars in Hematology, 2001
Despite the clinical use of deferoxamine for more than a quarter of a century, pharmacokinetic studies are few and have not been performed explicitly in patients with sickle cell disorders. Early studies with Intravenous administration to healthy volunteers and patients with transfusional overload showed that although peak concentrations of ...
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Despite the clinical use of deferoxamine for more than a quarter of a century, pharmacokinetic studies are few and have not been performed explicitly in patients with sickle cell disorders. Early studies with Intravenous administration to healthy volunteers and patients with transfusional overload showed that although peak concentrations of ...
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Pharmacokinetics of prostaglandins
Best Practice & Research Clinical Obstetrics & Gynaecology, 2003Naturally occurring prostaglandins (PGs) are rapidly metabolized in the human circulation. For clinical use a number of PG analogues have therefore been developed which are resistant to rapid inactivation. Among these are carboprost, gemeprost and misoprostol.
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