Results 321 to 330 of about 905,269 (391)

The Safety, Tolerability, and Pharmacokinetics of ALT-BB4 (A Novel Recombinant Hyaluronidase): A Randomized, Double-Blinded, Placebo-Controlled, Phase 1 Study in Healthy Volunteers. [PDF]

Dermatol Ther (Heidelb)
Lee JS, Kim W, Won CH, Lee YW, Lee S, Won H, Park SJ, Lee S, Kim SH, Yang J, Bahn G, Lee DH.   +11 more
europepmc   +1 more source

Anti‐PD‐1 Nanobody‐Armored MSLN CAR‐T Therapy for Malignant Mesothelioma: Preclinical and Clinical Studies

Advanced Science, EarlyView.
A novel therapy using engineered immune cells (NAC‐T cells) showed promise for refractory malignant mesothelioma. Based on the encouraging preclinical data, the first‐in‐human trial is initiated, demonstrating tolerable safety and promising anti‐tumor activity (ORR 63.6%, DCR 100%, including one CR).
Yan Sun, Haochen Yang, Qing Xu, Xingya Li, Jinxing Lou, Jianchun Duan, Jiachen Xu, Zhuqing Liu, Yong Xia, Zhicai Lin, Linlin Li, Dan Sun, Jiaguo Li, Tao Liu, Jun Guo, Wenfeng Xu, Weimin Zhu, Yi Liu, Boyang Sun, Jia Zhong, Lijie Rong, Qijun Qian, Chenqi Xu, Jie Wang   +23 more
wiley   +1 more source

State of Art of Dose Individualization to Support tacrolimus drug monitoring: What's Next? [PDF]

Transpl Int
Lloberas N, Fernández-Alarcón B, Vidal-Alabró A, Colom H.   +3 more
europepmc   +1 more source

Neurophilic Biomimetic Lipoprotein‐Mediated Targeted Nerve Growth Factor Delivery for Traumatic Brain Injury Therapy

Advanced Science, EarlyView.
Design of neurophilic biomimetic lipoprotein for intracerebral delivery of nerve growth factor (NGF) to traumatic brain injury (TBI). Nc‐rHDL@P can cross the BBB through ApoE3‐receptors interaction and target neurons via αRDP‐nAChR interaction. Nc‐rHDL@P delivers NGF to the lesion sites, rescues neurons, curbs inflammation, boosts sensorimotor and ...
Jialin Huang, Wenye Wang, Yidong Peng, Weiji Weng, Hanyu Wei, Qiyuan Feng, Antian Wang, Minjie Hu, Zhuoran Li, Shenyu Sun, Zhenghui He, Daiwen Zhang, Wenlan Qi, Yuhan Han, Zixuan Ma, Jiyuan Hui, Ru Gong, Yingwei Gao, Yong Lin, Jiyao Jiang, Xiaoling Gao, Junfeng Feng   +21 more
wiley   +1 more source

An Effective Oral Drug Delivery Route for Pharmacokinetic Complications: Spirulina Lipid Nanotechnology System

Advanced Science, EarlyView.
Spirulina‐nano system facilitates the formation of drug coating on spirulina's surface through electrostatic adsorption. It targets intestinal villi effectively and overcomes the pharmacokinetic complications of IBS‐D. This system successfully carried out the treatment of multiple symptoms, including diarrhea, visceral hypersensitivity, mental symptoms,
Jiahui Ye, Xinyi Wu, Jin Liu, Yongmi Guo, Chong Ji, Zhouyue Wang, Di Yang, Min Zhou   +7 more
wiley   +1 more source

The Effect of α-Mangostin on the Pharmacokinetic Profile of Tofacitinib in Rats Both In Vitro and In Vivo. [PDF]

Biopharm Drug Dispos
Yao J, Lu Z, Zhou Q, Mamun AA, Shi Y, Wang S, Yao Y.   +6 more
europepmc   +1 more source

Chromatography of anticancer drugs [PDF]

, 2013
Cserháti, Tibor, Szőgyi, Mária
core  

A Phase I open-label study to assess the pharmacokinetics, safety, and tolerability of capivasertib alone or in combination with paclitaxel in Chinese patients with advanced solid tumors. [PDF]

BMC Cancer
Zhang J, Liu X, Du Y, Mu Y, Meng Y, Sun Y, Zhang L, Chen C, Cullberg M, Fan E, Hu X.   +10 more
europepmc   +1 more source

Editorial: Diverse functions of drug transporters. [PDF]

Front Pharmacol
Granados JC, Cheung KWK, Prasad B.
europepmc   +1 more source

In vivo assessment of buparvaquone resistant Theileria annulata populations: genetic structure, transmission dynamics, drug susceptibility and pharmacokinetics. [PDF]

PLoS One
Hacilarlioglu S, Bilgic HB, Gokbulut C, Bakirci S, Aksulu A, Shiels B, Tait A, Kose O, Pekagirbas M, Weir W, Aksit D, Karagenc T.   +11 more
europepmc   +1 more source