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Pharmacokinetic and pharmacodynamic characterization of remimazolam in older Japanese adults who underwent general anesthesia at early stage of infusion. [PDF]
Sci RepUeshima S +8 more
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Correction to "Results From a Phase 1 Study Evaluating the Safety, Tolerability, Pharmacokinetics, Pharmacodynamics, and Efficacy of ANX005, a C1q Inhibitor, in Patients With Guillain-Barré Syndrome". [PDF]
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Biochemical Pharmacology, 2014
Pharmacokinetics (PK) is the study of the time course of the absorption, distribution, metabolism and excretion (ADME) of a drug, compound or new chemical entity (NCE) after its administration to the body. Following a brief introduction as to why knowledge of the PK properties of an NCE is critical to its selection as a lead candidate in a drug ...
Jianghong, Fan, Inés A M, de Lannoy
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Pharmacokinetics (PK) is the study of the time course of the absorption, distribution, metabolism and excretion (ADME) of a drug, compound or new chemical entity (NCE) after its administration to the body. Following a brief introduction as to why knowledge of the PK properties of an NCE is critical to its selection as a lead candidate in a drug ...
Jianghong, Fan, Inés A M, de Lannoy
openaire +5 more sources
Pharmacokinetics of methotrexate
Clinical Pharmacology & Therapeutics, 1973Methotrexate (Mtx) is a competitive inhibitor of the enzymatic activity of dihydrofolate reductase, decreasing the reduction of folic acid to tetrahydrofolate and thereby the activity of thymi dilate kinase. The net effect is a decrease in biosynthesis of deoxyribonucleic acid (DNA) primarily, but also of ribonucleic acid (RNA) and protein. Whereas the
D H, Huffman +3 more
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Pharmacokinetics of Teicoplanin
Chemotherapy, 1988We investigated the pharmacokinetic properties of teicoplanin, after 200 mg i.v. and i.m. administration in 10 healthy male subjects by assuming a three-compartment open model with elimination from the central compartment. The mean peak plasma level was 7.16 micrograms/ml reached after 2.26 h.
RIPA, Sandro +3 more
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