Results 111 to 120 of about 477,265 (189)

Chaperone-Assisted Host–Guest Interactions Revealed by Single-Molecule Force Spectroscopy

, 2019
The recent discovery of ultra-high binding affinities in cucurbit[7]­uril (CB7)-based host–guest pairs in an aqueous environment has rendered CB7 a rather attractive material in analytical and biomedical applications.
Lyle Isaacs (365049), Dilanka V. D. Walpita Kankanamalage (7841630), Changpeng Hu (5233151), Shankar Pandey (7479635), Hanbin Mao (156088), Janarthanan Jayawickramarajah (1339188), Xiao Zhou (122661)   +6 more
core   +1 more source

Correction to: A pharmacological chaperone improves memory by reducing Aβ and tau neuropathology in a mouse model with plaques and tangles. [PDF]

Mol Neurodegener, 2021
Li JG, Chiu J, Ramanjulu M, Blass BE, Praticò D.   +4 more
europepmc   +1 more source

Pharmacological chaperone for the structured domain of human prion protein.

, 2010
In prion diseases, the misfolded protein aggregates are derived from cellular prion protein (PrP(C)). Numerous ligands have been reported to bind to human PrP(C) (huPrP), but none to the structured region with the affinity required for a pharmacological ...
Emmanuel Risse, Quarterman, Emma, Waltho, Jonathan P; id_orcid, Andrew J. Nicoll, M. Howard Tattum, Emma Quarterman, Clarke, A.R, Jackson, G.S, Anthony R. Clarke, Risse, E, Nicoll, A.J, Jackson, Graham S, Trevitt, Clare R, Clare R. Trevitt, Collinge, John, Risse, Emmanuel, Wright, Connor, Farrow, M, Sessions, Richard B, Richard B. Sessions, Tattum, M Howard, Howard Tattum, M, Wright, C, Ibarra, Amaurys Avila, Nicoll, Andrew J, Farrow, Mark, Quarterman, E, Collinge, J, Jonathan P. Waltho, Mark Farrow, Sessions, R.B, Graham S. Jackson, John Collinge, Avila Ibarra, A, Clarke, Anthony R, Trevitt, C.R, Connor Wright, Amaurys Avila Ibarra, Waltho, J.P   +38 more
core   +1 more source

Modulation of Heat Shock Proteins Levels in Health and Disease: An Integrated Perspective in Diagnostics and Therapy

Cells
Heat shock proteins belong to a highly conserved family of chaperone proteins, and in addition to their participation in the regulation of cellular proteostasis (folding of polypeptides and proteins, disaggregation of incorrectly folded peptides, and ...
Elena Mikhailova, Alexandra Sokolenko, Stephanie E. Combs, Maxim Shevtsov   +3 more
doaj   +1 more source

Functional rescue and AI analysis of a human inactivating GPCR mutation using a small molecule

EMBO Molecular Medicine
G protein-coupled receptors (GPCRs) carry out the majority of cellular transmembrane signaling. Many pathologies have underlying GPCR mutations, most of which cause misfolding and GPCR cell surface trafficking failure.
Debajyoti Das, Amanda Wyatt, Sarath Sivaprasad, Vanessa Wahl, Sen Qiao, Fabien Ectors, Zulfiah M Moosa, Claire L Newton, Mario Fritz, Robert P Millar, Ulrich Boehm   +10 more
doaj   +1 more source

Intoxication of mammalian cells with binary clostridial enterotoxins is inhibited by the combination of pharmacological chaperone inhibitors. [PDF]

Naunyn Schmiedebergs Arch Pharmacol, 2021
Ernst K, Sailer J, Braune M, Barth H.
europepmc   +1 more source

Chaperone-mediated autophagy degrades mutant p53

, 2013
Accumulation of mutant p53 proteins contributes to tumor development and metastasis, yet little is known abut how to selectively reduce the cellular load of mutant p53.
Yuan, Junying, Vakifahmetoglu-Norberg, Helin, Pan, Lifeng, Kroemer, Guido, Coloff, Jonathan L, Iwanicki, Marcin P, Xia, Hong-guang, Ofengeim, Dimitry, Brugge, Joan S, Kim, Minsu, Ince, Tan A   +10 more
core   +1 more source

Functional restoration of conformational (R175H) and contact (R273H) mutant p53 by Bacillus-derived Hydroxymycotrienin A in non-small cell lung cancer: a computational approach

Frontiers in Bioinformatics
IntroductionThe TP53 mutations in Non-Small Cell Lung Cancer (NSCLC) remain a formidable clinical challenge. Current strategies, using the covalent binder APR-246, are limited by off-target toxicity and resistance.MethodsThis study screens 1,580 Bacillus-
Adeline Celina Rufus, Sidharth Kumar N, Magesh Ramasamy, Elavarashi Elangovan   +3 more
doaj   +1 more source

Pharmacological Chaperone [PDF]

, 2020
openaire   +1 more source

Misfolding of Lysosomal α-Galactosidase a in a Fly Model and Its Alleviation by the Pharmacological Chaperone Migalastat. [PDF]

Int J Mol Sci, 2020
Braunstein H, Papazian M, Maor G, Lukas J, Rolfs A, Horowitz M.   +5 more
europepmc   +1 more source