Results 121 to 130 of about 477,265 (189)

A pharmacological chaperone improves memory by reducing Aβ and tau neuropathology in a mouse model with plaques and tangles. [PDF]

Mol Neurodegener, 2020
Li JG, Chiu J, Ramanjulu M, Blass BE, Praticò D.   +4 more
europepmc   +1 more source

Assessment of Gene Variant Amenability for Pharmacological Chaperone Therapy with 1-Deoxygalactonojirimycin in Fabry Disease. [PDF]

Int J Mol Sci, 2020
Lukas J, Cimmaruta C, Liguori L, Pantoom S, Iwanov K, Petters J, Hund C, Bunschkowski M, Hermann A, Cubellis MV, Rolfs A.   +10 more
europepmc   +1 more source

Synthesis of a C-2 Functionalized l-Iduronic Acid Derivative as a Candidate Pharmacological Chaperone for MPS II (Hunter Syndrome). [PDF]

Chem Asian J
Nagendra V, Mohamed S, See NW, Wimmer N, Neumann D, Trim PJ, Snel M, Brock AJ, Clegg JK, Gandhi NS, Hemsley KM, Lau AA, Ferro V.   +12 more
europepmc   +1 more source

Two novel <i>GAA</i> missense variants and a known VUS in pompe disease: Functional characterization and pharmacological chaperone therapy. [PDF]

Genes Dis
Xia Y, Song Y, Peng Z, Meng Y, Yu S, Zhang X.   +5 more
europepmc   +1 more source

The sodium/glucose cotransporter 2 inhibitor empagliflozin is a pharmacological chaperone of cardiac Na_v1.5 channels. [PDF]

Am J Physiol Heart Circ Physiol
Sauer J, Marksteiner J, Hohenegger M, Todt H, Kubista H, Dostal C, Kiss A, Podesser BK, Salzer I, Koenig X, Stary-Weinzinger A, Hilber K, Kudlacek O.   +12 more
europepmc   +1 more source

Editorial Note: The Pharmacological Chaperone AT2220 Increases Recombinant Human Acid α-Glucosidase Uptake and Glycogen Reduction in a Mouse Model of Pompe Disease. [PDF]

PLoS One
PLOS One Editors.
europepmc   +1 more source

Characterizing the inhibition of α-synuclein oligomerization by a pharmacological chaperone that prevents prion formation by the protein PrP. [PDF]

Protein Sci, 2019
Dong C, Garen CR, Mercier P, Petersen NO, Woodside MT.   +4 more
europepmc   +1 more source

A Study of the Inhibitory and Pharmacological Chaperone Effects of Bupropion and Ibogaine on Monoamine Transporters

In the last 20 or so years, significant advancements in our understanding of membrane protein structures have been driven by progress in cryo-electron microscopy, X-ray crystallography and in silico modeling.
Williams, Erin Quinn
core  

In Vitro Enzyme Measurement to Test Pharmacological Chaperone Responsiveness in Fabry and Pompe Disease. [PDF]

J Vis Exp, 2017
Lukas J, Knospe AM, Seemann S, Citro V, Cubellis MV, Rolfs A.   +5 more
europepmc   +1 more source

Identification of Small Molecule Compounds for Pharmacological Chaperone Therapy of Aspartylglucosaminuria. [PDF]

Sci Rep, 2016
Banning A, Gülec C, Rouvinen J, Gray SJ, Tikkanen R.   +4 more
europepmc   +1 more source