Results 121 to 130 of about 16,862 (246)
Pharmacological chaperones for the oxytocin receptor increase oxytocin responsiveness in myometrial cells. [PDF]
J Biol Chem, 2022 Malik M +7 more
europepmc +1 more source
OXCT1‐driven succinylation of PSMG3 stabilizes the proteasome to facilitate picornavirus replication
iMetaOmics, EarlyView.Upon entering the pig, foot‐and‐mouth disease virus (FMDV) regulates host glycolysis and the citrate cycle by modulating the expression of metabolic enzymes, resulting in changes in post‐translational modifications (PTMs) including succinylation, lactylation, crotonylation, acetylation, and phosphorylation.
Huisheng Liu +9 more
wiley +1 more source
Insights into cannabinoid receptor 2 (CB2) anterograde trafficking and pharmacological chaperoning
Cellular and Molecular Life SciencesCannabinoid Receptor 2 (CB2) is a promising therapeutic target for modulating inflammation. Canonical signalling responses to receptor ligands are critically dependent on cell surface receptor expression.
Caitlin R. M. Oyagawa +4 more
doaj +1 more source
Design and synthesis of biologically active carbaglycosylamines: From glycosidase inhibitors to pharmacological chaperones. [PDF]
Proc Jpn Acad Ser B Phys Biol Sci, 2022 Ogawa S, Kuno S, Toyokuni T.
europepmc +1 more source
iNew Medicine, EarlyView.ABSTRACT Human papillomavirus (HPV) is a double‐stranded DNA virus that infects human skin and mucosal tissues exclusively. The German scientist Harald zur Hausen was awarded the 2008 Nobel Prize in Physiology or Medicine for his discovery of the link between HPV infection and cervical cancer.
Fang Zhu +5 more
wiley +1 more source
Functional Rescue of Inactivating Mutations of the Human Neurokinin 3 Receptor Using Pharmacological Chaperones. [PDF]
Int J Mol Sci, 2022 Anderson RC +8 more
europepmc +1 more source
iNew Medicine, EarlyView.This graphical abstract illustrates a bidirectional vicious cycle between Alzheimer’s disease (AD) and circadian rhythm disturbance (CRD). On the one hand, AD pathology, including amyloid‐β (Aβ) plaque deposition and tau hyperphosphorylation, may damage the suprachiasmatic nucleus (SCN) and disrupt melatonin signaling, leading to sleep fragmentation ...
Jiajia Qin +10 more
wiley +1 more source
Neuromodulation: Technology at the Neural Interface, EarlyView., 2021 Abstract Objectives Acute cerebral ischemia is characterized by several pathological processes evolving during time, which contribute to the final tissue damage. Secondary processes, such as prolonged inflammatory response, impaired mitochondrial function and oxidative stress, are responsible for the progression of brain injury to the peri‐infarct area,
Fioravante Capone +8 more
wiley +1 more source
GSK3β drives early diabetic tubulopathy via TFEB‐mediated mitochondrial dysfunction
Interdisciplinary Medicine, EarlyView.Mitochondrial dysfunction, including mitochondrial biogenesis, mitophagy, dynamics and oxidative stress, occurs in the early stages of diabetic tubulopathy, which precede proteinuria and renal histological changes. GSK3β is a potential novel biomarker for the prediction of diabetic tubulopathy.
Lan Yao +10 more
wiley +1 more source