Results 1 to 10 of about 1,302 (169)

Multivalent Pyrrolidine Iminosugars: Synthesis and Biological Relevance

Molecules, 2022
Recently, the strategy of multivalency has been widely employed to design glycosidase inhibitors, as glycomimetic clusters often induce marked enzyme inhibition relative to monovalent analogs.
Yali Wang, Jian Xiao, Aiguo Meng, Chunyan Liu   +3 more
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Exploring the Potential of Iminosugars as Antivirals for Crimean-Congo Haemorrhagic Fever Virus, Using the Surrogate Hazara Virus: Liquid-Chromatography-Based Mapping of Viral N-Glycosylation and In Vitro Antiviral Assays

Pathogens, 2023
Crimean-Congo haemorrhagic fever virus (CCHFV) is a pathogen of increasing public health concern, being a widely distributed arbovirus and the causative agent of the potentially fatal Crimean-Congo haemorrhagic fever. Hazara virus (HAZV) is a genetically
Beatrice E. Tyrrell, Abhinav Kumar, Bevin Gangadharan, Dominic Alonzi, Juliane Brun, Michelle Hill, Tehmina Bharucha, Andrew Bosworth, Victoria Graham, Stuart Dowall, Joanna L. Miller, Nicole Zitzmann   +11 more
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Gold nanoparticles are suitable cores for building tunable iminosugar multivalency† [PDF]

RSC Advances, 2015
The first example of iminosugars multimerization based on gold nanoparticle cores was achieved by a straightforward synthetic strategy based on the use of simple glycosides of α-d-mannose or β-d-glucose to modulate the density of biologically active ...
C. Matassini, M. Marradi, F. Cardona, C. Parmeggiani, I. Robina, A. J. Moreno-Vargas, S. Penadés, A. Goti   +7 more
doaj   +1 more source

Iminosugars With Endoplasmic Reticulum α-Glucosidase Inhibitor Activity Inhibit ZIKV Replication and Reverse Cytopathogenicity in vitro

Frontiers in Microbiology, 2020
Zika virus (ZIKV), a vector-borne virus of the family Flaviviridae, continues to spread and remains a significant global public health threat. Currently, there are no approved vaccines or antivirals against ZIKV.
Gitanjali Bhushan, Levina Lim, Ian Bird, Shubhada K. Chothe, Ruth H. Nissly, Suresh V. Kuchipudi   +5 more
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Synthesis of N-Substituted Iminosugar C-Glycosides and Evaluation as Promising α-Glucosidase Inhibitors

Molecules, 2022
A series of N-substituted iminosugar C-glycosides were synthesized and tested for α-glucosidase inhibition. The results suggested that 6e is a promising and potent α-glucosidase inhibitor.
Haibo Wang, Senling Tang, Guoqing Zhang, Yang Pan, Wei Jiao, Huawu Shao   +5 more
doaj   +1 more source

Crystal structure of 6-azido-6-deoxy-1,2-O-isopropylidene-α-d-glucofuranose

Acta Crystallographica Section E: Crystallographic Communications, 2020
Short syntheses to high Fsp3 index natural-product analogues such as iminosugars are of paramount importance in the investigation of their biological activities and reducing the use of protecting groups is an advantageous synthetic strategy.
Adam Wood, Paul V. Bernhardt, Ian van Altena, Michela I. Simone   +3 more
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Bambus[4,6]urils as Dual Scaffolds for Multivalent Iminosugar Presentation and Ion Transport: Access to Unprecedented Glycosidase-Directed Anion Caging Agents

Molecules, 2022
Bambusurils, BU[4] and BU[6], were used for the first time as multivalent scaffolds to link glycosidases inhibitors derived from 1-deoxynojirimycin (DNJ).
Marine Lafosse, Yan Liang, Jérémy P. Schneider, Elise Cartier, Anne Bodlenner, Philippe Compain, Marie-Pierre Heck   +6 more
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Synthesis of Piperidine Nucleosides as Conformationally Restricted Immucillin Mimics

Molecules, 2021
The de novo synthesis of piperidine nucleosides from our homologating agent 5,6-dihydro-1,4-dithiin is herein reported. The structure and conformation of nucleosides were conceived to faithfully resemble the well-known nucleoside drugs Immucillins H and ...
Maria De Fenza, Anna Esposito, Daniele D’Alonzo, Annalisa Guaragna   +3 more
doaj   +1 more source

Selective Targeting of the Interconversion between Glucosylceramide and Ceramide by Scaffold Tailoring of Iminosugar Inhibitors

Molecules, 2019
A series of simple C-alkyl pyrrolidines already known as cytotoxic inhibitors of ceramide glucosylation in melanoma cells can be converted into their corresponding 6-membered analogues by means of a simple ring expansion.
Cécile Baudoin-Dehoux, Tessa Castellan, Frédéric Rodriguez, Arnaud Rives, Fabien Stauffert, Virginie Garcia, Thierry Levade, Philippe Compain, Yves Génisson   +8 more
doaj   +1 more source

A Novel Iminosugar UV-12 with Activity against the Diverse Viruses Influenza and Dengue (Novel Iminosugar Antiviral for Influenza and Dengue)

Viruses, 2015
Iminosugars are capable of targeting the life cycles of multiple viruses by blocking host endoplasmic reticulum α-glucosidase enzymes that are required for competent replication of a variety of enveloped, glycosylated viruses.
Kelly L. Warfield, Emily Plummer, Dominic S. Alonzi, Gary W. Wolfe, Aruna Sampath, Tam Nguyen, Terry D. Butters, Sven G. Enterlein, Eric J. Stavale, Sujan Shresta, Urban Ramstedt   +10 more
doaj   +1 more source